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- 2019
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Journal article (peer-reviewed)
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| 2. |
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| 3. |
- Wang, Fang, et al.
(author)
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Emerging contaminants: A One Health perspective
- 2024
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In: Innovation. - 2666-6758. ; 5
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Research review (peer-reviewed)abstract
- Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both people and the planet. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the ongoing efforts to establish the UN's Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.
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| 4. |
- Lin, Yuze, et al.
(author)
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Mapping Polymer Donors toward High-Efficiency Fullerene Free Organic Solar Cells
- 2017
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In: Advanced Materials. - : WILEY-V C H VERLAG GMBH. - 0935-9648 .- 1521-4095. ; 29:3
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Journal article (peer-reviewed)abstract
- Five polymer donors with distinct chemical structures and different electronic properties are surveyed in a planar and narrow-bandgap fused-ring electron acceptor (IDIC)-based organic solar cells, which exhibit power conversion efficiencies of up to 11%.
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| 5. |
- Yu, Wenjin, et al.
(author)
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Deep Learning-Based Classification of Cancer Cell in Leptomeningeal Metastasis on Cytomorphologic Features of Cerebrospinal Fluid
- 2022
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In: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 12, s. 1-11
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Journal article (peer-reviewed)abstract
- Background: It is a critical challenge to diagnose leptomeningeal metastasis (LM), given its technical difficulty and the lack of typical symptoms. The existing gold standard of diagnosing LM is to use positive cerebrospinal fluid (CSF) cytology, which consumes significantly more time to classify cells under a microscope.Objective: This study aims to establish a deep learning model to classify cancer cells in CSF, thus facilitating doctors to achieve an accurate and fast diagnosis of LM in an early stage.Method: The cerebrospinal fluid laboratory of Xijing Hospital provides 53,255 cells from 90 LM patients in the research. We used two deep convolutional neural networks (CNN) models to classify cells in the CSF. A five-way cell classification model (CNN1) consists of lymphocytes, monocytes, neutrophils, erythrocytes, and cancer cells. A four-way cancer cell classification model (CNN2) consists of lung cancer cells, gastric cancer cells, breast cancer cells, and pancreatic cancer cells. Here, the CNN models were constructed by Resnet-inception-V2. We evaluated the performance of the proposed models on two external datasets and compared them with the results from 42 doctors of various levels of experience in the human-machine tests. Furthermore, we develop a computer-aided diagnosis (CAD) software to generate cytology diagnosis reports in the research rapidly.Results: With respect to the validation set, the mean average precision (mAP) of CNN1 is over 95% and that of CNN2 is close to 80%. Hence, the proposed deep learning model effectively classifies cells in CSF to facilitate the screening of cancer cells. In the human-machine tests, the accuracy of CNN1 is similar to the results from experts, with higher accuracy than doctors in other levels. Moreover, the overall accuracy of CNN2 is 10% higher than that of experts, with a time consumption of only one-third of that consumed by an expert. Using the CAD software saves 90% working time of cytologists.Conclusion: A deep learning method has been developed to assist the LM diagnosis with high accuracy and low time consumption effectively. Thanks to labeled data and step-by-step training, our proposed method can successfully classify cancer cells in the CSF to assist LM diagnosis early. In addition, this unique research can predict cancer’s primary source of LM, which relies on cytomorphologic features without immunohistochemistry. Our results show that deep learning can be widely used in medical images to classify cerebrospinal fluid cells. For complex cancer classification tasks, the accuracy of the proposed method is significantly higher than that of specialist doctors, and its performance is better than that of junior doctors and interns. The application of CNNs and CAD software may ultimately aid in expediting the diagnosis and overcoming the shortage of experienced cytologists, thereby facilitating earlier treatment and improving the prognosis of LM.
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| 6. |
- Cao, Ning, 1987-, et al.
(author)
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The role of internal feedbacks in sustaining multi-centennial variability of the Atlantic Meridional Overturning Circulation revealed by EC-Earth3-LR simulations
- 2023
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In: Earth and Planetary Science Letters. - 0012-821X .- 1385-013X. ; 621
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Journal article (peer-reviewed)abstract
- A significant multi-centennial climate variability with a distinct peak at approximately 200 years is observed in a pre-industrial (PI) control simulation using the EC-Earth3-LR climate model. This oscillation originates predominately from the North Atlantic and displays a strong association with the Atlantic Meridional Overturning Circulation (AMOC). Our study identifies the interplay between salinity advection feedback and vertical mixing in the subpolar North Atlantic as key roles in providing the continues internal energy source to maintain this multi-centennial oscillation. The perturbation flow of mean subtropical-subpolar salinity gradients serves as positive feedback to sustain the AMOC anomaly, while the mean advection of salinity anomalies and the vertical mixing or convection acts as negative feedback, constraining the AMOC anomaly. Notably, this low-frequency variability persists even in a warmer climate with weakened AMOC, emphasizing the robustness of the salinity advection feedback mechanism.
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| 7. |
- Gravgaard Askjær, Thomas, et al.
(author)
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Multi-centennial Holocene climate variability in proxy records and transient model simulations
- 2022
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In: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 296
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Journal article (peer-reviewed)abstract
- Variability on centennial to multi-centennial timescales is mentioned as a feature in reconstructions of the Holocene climate. As more long transient model simulations with complex climate models become available and efforts have been made to compile large proxy databases, there is now a unique opportunity to study multi-centennial variability with greater detail and a large amount of data than earlier. This paper presents a spectral analysis of transient Holocene simulations from 9 models and 120 proxy records to find the common signals related to oscillation periods and geographic dependencies and discuss the implications for the potential driving mechanisms. Multi-centennial variability is significant in most proxy records, with the dominant oscillation periods around 120–130 years and an average of 240 years. Spectra of model-based global mean temperature (GMT) agree well with proxy evidence with significant multi-centennial variability in all simulations with the dominant oscillation periods around 120–150 years. It indicates a comparatively good agreement between model and proxy data. A lack of latitudinal dependencies in terms of oscillation period is found in both the model and proxy data. However, all model simulations have the highest spectral density distributed over the Northern hemisphere high latitudes, which could indicate a particular variability sensitivity or potential driving mechanisms in this region. Five models also have differentiated forcings simulations with various combinations of forcing agents. Significant multi-centennial variability with oscillation periods between 100 and 200 years is found in all forcing scenarios, including those with only orbital forcing. The different forcings induce some variability in the system. Yet, none appear to be the predominant driver based on the spectral analysis. Solar irradiance has long been hypothesized to be a primary driver of multi-centennial variability. However, all the simulations without this forcing have shown significant multi-centennial variability. The results then indicate that internal mechanisms operate on multi-centennial timescales, and the North Atlantic-Arctic is a region of interest for this aspect.
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| 8. |
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| 9. |
- Tang, Ailing, et al.
(author)
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Simultaneously Achieved High Open-Circuit Voltage and Efficient Charge Generation by Fine-Tuning Charge-Transfer Driving Force in Nonfullerene Polymer Solar Cells
- 2018
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In: Advanced Functional Materials. - : WILEY-V C H VERLAG GMBH. - 1616-301X .- 1616-3028. ; 28:6
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Journal article (peer-reviewed)abstract
- To maximize the short-circuit current density (J(SC)) and the open circuit voltage (V-OC) simultaneously is a highly important but challenging issue in organic solar cells (OSCs). In this study, a benzotriazole-based p-type polymer (J61) and three benzotriazole-based nonfullerene small molecule acceptors (BTA1-3) are chosen to investigate the energetic driving force for the efficient charge transfer. The lowest unoccupied molecular orbital (LUMO) energy levels of small molecule acceptors can be fine-tuned by modifying the end-capping units, leading to high V-OC (1.15-1.30 V) of OSCs. Particularly, the LUMO energy level of BTA3 satisfies the criteria for efficient charge generation, which results in a high V-OC of 1.15 V, nearly 65% external quantum efficiency, and a high power conversion efficiency (PCE) of 8.25%. This is one of the highest V-OC in the high-performance OSCs reported to date. The results imply that it is promising to achieve both high J(SC) and V-OC to realize high PCE with the carefully designed nonfullerene acceptors.
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| 10. |
- Xue, Xiaoyin, et al.
(author)
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PEDOT:PSS @Molecular Sieve as Dual-Functional Additive to Enhance Electrochemical Performance and Stability of Ni-Rich NMC Lithium-Ion Batteries
- 2020
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In: Energy Technology. - : Wiley. - 2194-4288 .- 2194-4296. ; 8:10
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Journal article (peer-reviewed)abstract
- Molecular sieves (MSs) coated with conductive polymer (PEDOT:PSS) are used as water scavengers to modify the nickel‐rich LiNi1–x–yCoxMnyO2 (NMC)‐layered cathode. This strategy proactively captures residual water in the battery system without affecting the transport performance of electrons and Li+ ions. The moisture content and nuclear magnetic resonance (NMR) tests show that MSs after coating still maintain good water absorption characteristics and inhibit the decomposition of the electrolyte. The conductivity of the PEDOT:PSS@MS‐NMC electrode is 1.08 × 10−4 S cm−1, which is improved by 63.9%, compared with the MS‐NMC electrode. Through X‐ray photoelectron spectroscopy, transmission electron microscopy, and scanning electron microscopy measurements, it is also shown that the surface structure stability and particle integrity for PEDOT:PSS@MS‐NMC electrode is well retained. After 500 cycles, the capacity retention of the composite cathode is 71.3%, which is higher than that of the NMC (38.3%) and MS‐NMC cathode (62.4%). This is a novel and effective strategy to suppress side reactions at the electrode interface and improve electrode stability, capacity retention, and cycle performance of the Ni‐rich NMC cathode.
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| 11. |
- Yang, Haijun, et al.
(author)
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Anatomizing the Ocean´s role in ENSO changes under global warming
- 2008
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In: Journal of climate. - 1520-0442. ; 21:24, s. 6539-6555
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Journal article (peer-reviewed)abstract
- A revisit on observations shows that the tropical El Niño–Southern Oscillation (ENSO) variability, after removing both the long-term trend and decadal variation of the background climate, has been enhanced by as much as 50% during the past 50 yr. This is inconsistent with the changes in the equatorial atmosphere, which shows a slowdown of the zonal Walker circulation and tends to stabilize the tropical coupling system. The ocean role is highlighted in this paper. The enhanced ENSO variability is attributed to the strengthened equatorial thermocline that acts as a destabilizing factor of the tropical coupling system. To quantify the dynamic effect of the ocean on the ENSO variability under the global warming, ensemble experiments are performed using a coupled climate model [Fast Ocean Atmosphere Model (FOAM)], following the “1pctto2x” scenario defined in the Intergovernmental Panel on Climate Change (IPCC) reports. Term balance analyses on the temperature variability equation show that the anomalous upwelling of the mean vertical temperature gradient (referred as the “local term”) in the eastern equatorial Pacific is the most important destabilizing factor to the temperature variabilities. The magnitude of local term and its change are controlled by its two components: the mean vertical temperature gradient Tz and the “virtual vertical heat flux” −w′T′. The former can be viewed as the background of the latter and these two components are positively correlated. A stronger Tz is usually associated with a bigger upward heat flux −w′T′, which implies a bigger impact of thermocline depth variations on SST. The Tz is first enhanced during the transient stage of the global warming with a 1% yr−1 increase of CO2, and then reduced during the equilibrium stage with a fixed doubled CO2. This turnaround in Tz determines the turnaround of ENSO variability in the entire global warming period.
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| 12. |
- Yang, Haijun, et al.
(author)
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Heat Transport Compensation in Atmosphere and Ocean over the Past 22,000 Years
- 2015
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Journal article (peer-reviewed)abstract
- The Earth's climate has experienced dramatic changes over the past 22,000 years; however, the total meridional heat transport (MHT) of the climate system remains stable. A 22,000-year-long simulation using an ocean-atmosphere coupled model shows that the changes in atmosphere and ocean MHT are significant but tend to be out of phase in most regions, mitigating the total MHT change, which helps to maintain the stability of the Earth's overall climate. A simple conceptual model is used to understand the compensation mechanism. The simple model can reproduce qualitatively the evolution and compensation features of the MHT over the past 22,000 years. We find that the global energy conservation requires the compensation changes in the atmosphere and ocean heat transports. The degree of compensation is mainly determined by the local climate feedback between surface temperature and net radiation flux at the top of the atmosphere. This study suggests that an internal mechanism may exist in the climate system, which might have played a role in constraining the global climate change over the past 22,000 years.
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| 13. |
- Yang, Haijun, et al.
(author)
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多百年际气候变率 : 观测、理论与模拟研究 [Multi-centennial climate variability: Observational, theoretical and modeling studies]
- 2023
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In: Chinese Science Bulletin. - 0023-074X .- 2095-9419. ; 68:16, s. 2037-2045
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Journal article (peer-reviewed)abstract
- Research using long-term proxy data suggests the existence of multi-centennial climate variability in the Earth’s climate system. Its origin and mechanism have been bewildering for climatologists and archaeologists for a long time. Considering that the variation of external forcing of the Earth’ climate was relatively small from the mid-Holocene to the pre-industrial time, it is important to investigate the role of internal natural oscillation of the climate system during this period. The Atlantic meridional overturning circulation (AMOC) is thought to be the first candidate for such multi-centennial timescale variability. It is thus critical to investigate systematically the connection between the AMOC and the Earth climate system at this timescale. From the mid-Holocene to the pre-industrial time, the human civilization experienced rapid development. Historical documents in China suggest that in the past 2000 years, the historical climate in China had a low-frequency variation with 200–300 year period, which might have affected the ancient Chinese civilization. The multi-centennial variability of the AMOC may have played a role in the vax and vane of the human civilization.Currently, there is a lack of in-depth studies on the multi-centennial variability of the AMOC. This is mainly due to the following factors. First, the time period of modern instrumental observations is less than 200 years, which is not long enough to confirm the existence of the multi-centennial climate variability. Second, there is a lack of a well-recognized theory that can account for the multi-centennial variability of the AMOC. Third, it is much easier for a researcher to study the Earth climate change due to external forcing than to study the internal variability of the Earth climate system under a stable external forcing, particularly at this long timescale.Several coupled Earth climate system models have simulated the multi-centennial variability of the AMOC. However, the results from both coupled models and proxy data include comprehensive factors. To fundamentally understand the multi-centennial climate variability, a simple theoretical model is needed. Unfortunately, there is a lack of theoretical studies on the internal multi-centennial variability under the background of stable climate.In this work, we systematically review the current studies on multi-centennial climate variability from observational, theoretical and coupled modeling aspects. We hope that by proposing innovative theory and creative climate modeling approach, we can identify the intrinsic mode of multi-centennial climate variability, picture its spatial pattern, decipher the origin of its timescale, and reveal its internal mechanism. The outcome of these studies will help us understand deeply the wax and wane of the human civilization during the past several thousand years. It will also be of great significance for a better prediction of the long-term trend of future climate change.
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| 14. |
- Yang, Kunpeng, et al.
(author)
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North Atlantic Ocean–Originated Multicentennial Oscillation of the AMOC : A Coupled Model Study
- 2024
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In: Journal of Climate. - 0894-8755 .- 1520-0442. ; 37:9, s. 2789-2807
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Journal article (peer-reviewed)abstract
- Using a CESM1 control simulation, we conduct a follow-up study to advance our earlier theoretical research on the multicentennial oscillation (MCO) of the Atlantic meridional overturning circulation (AMOC). The modeled AMOC MCO primarily arises from internal oceanic processes in the North Atlantic, potentially representing a North Atlantic Ocean–originated mode of AMOC multicentennial variability (MCV) in reality. Specifically, this AMOC MCO is mainly driven by salinity variation in the subpolar upper North Atlantic, which dominates local density variation. Salinity anomaly in the subpolar upper ocean is enhanced by the well-known positive salinity advection feedback that is realized through anomalous advection in the subtropical to subpolar upper ocean. Meanwhile, mean advection moves salinity anomaly in the subtropical intermediate ocean northward, weakening the subpolar upper salinity anomaly and leading to its phase change. The salinity anomalies have a clear three-dimensional life cycle around the North Atlantic. The mechanism and time scale of the modeled AMOC MCO are consistent with our earlier theoretical studies. In the theoretical model, artificially deactivating either the anomalous or mean advection in the AMOC upper branch prevents it from exhibiting AMOC MCO, underscoring the indispensability of both the anomalous and mean advections in this North Atlantic Ocean–originated AMOC MCO. In our coupled model simulation, the South Atlantic and Southern Oceans do not exhibit variabilities synchronous with the AMOC MCO; the Arctic Ocean’s contribution to the subpolar upper salinity anomaly is much weaker than the North Atlantic. Hence, this North Atlantic Ocean–originated AMOC MCO is distinct from the previously proposed Southern Ocean–originated and Arctic Ocean–originated AMOC MCOs.
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| 15. |
- Zhang, Hao, et al.
(author)
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A simple method to enhance the lifetime of Ni-rich cathode by using low-temperature dehydratable molecular sieve as water scavenger
- 2019
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In: Journal of Power Sources. - : ELSEVIER. - 0378-7753 .- 1873-2755. ; 435
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Journal article (peer-reviewed)abstract
- Ni-rich cathode materials have received much attention because of their high specific capacity, low cost and environmentally friendly characteristic. However, the nickel-rich cathode is extremely sensitive to moisture, which results in poor structure stability and electrochemical performance. Herein, we demonstrate an efficient and simple route to prolong the lifetime of nickel-rich cathode by introducing a low-temperature dehydratable molecular sieve as water scavenger. The residual water content in electrolyte measurement and nuclear magnetic resonance test manifest that molecular sieve can effectively fix the trace H2O and reduce the decomposition rate of electrolyte from 16.6% to 4.0%, respectively. Transmission electron microscopy, scanning electron microscopy and X-ray photoelectron spectroscopy confirm that the molecular sieve inhibits the fragmentation of the electrode and the side reactions on the surface of the cathode. This approach improves structural integrity and stabilizes surface structure of the cathode, which increases the capacity retention without sacrificing rate performance. This effective strategy can be extended to other cathode materials which are sensitive to moisture to realize good cycling stability.
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