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- Zhu, Zhenlong, et al.
(författare)
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PINCH expression and its significance in esophageal squamous cell carcinoma
- 2008
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Ingår i: Disease Markers. - : Hindawi Limited. - 0278-0240 .- 1875-8630. ; 25:2, s. 75-80
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Tidskriftsartikel (refereegranskat)abstract
- Particularly interesting new cysteine-histidine rich protein (PINCH), as a newly discovered protein of LIM family members, may play a role in signal transduction of integrin and growth factor, and involved in the incidence and development of tumors. PINCH protein is overexpressed in tumor-associated stroma of several types of tumors. However, there is no study of the PINCH in esophageal cancer, therefore we investigated PINCH expression in esophageal squamous cell carcinomas and its clinicopathogical significance in the patients. PINCH expression was immunohistochemically examined in 20 normal esophageal samples and 64 esophageal squamous cell carcinomas. The results showed that PINCH expression in the stroma of cancers was heterogeneous, and its positive rate (56%) was higher than that of normal esophageal mucosa (5%, p<0.0001). The stronger staining was observed at the invasive edge of tumor when compared to the inner area of tumor. The rate of positive PINCH (90%) in the cases with lymph node metastasis was higher than that (41%) in the cases without metastasis (p<0.0001). PINCH expression was not correlated with patients’ gender, age, tumor location, size and differentiation (p>0.05). The results suggest that PINCH protein may be a marker of tumor associated-stroma involving tumor development, and predicting the ability of invasion and metastasis of esophageal squamous cell carcinoma.
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| 2. |
- Wan, Wenxin, et al.
(författare)
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Operating conditions combination analysis method of optimal water management state for PEM fuel cell
- 2023
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Ingår i: Green Energy and Intelligent Transportation. - 2773-1537 .- 2097-2512. ; 2:4
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Tidskriftsartikel (refereegranskat)abstract
- The water content of proton exchange membrane fuel cells (PEMFCs) affects the transport of reactants and the conductivity of the membrane. Effective water management measures can improve the performance and extend the lifespan of the fuel cell. The water management state of the stack is influenced by various external operating conditions, and optimizing the combination of these conditions can improve the water management state within the stack. Considering that the stack's internal resistance can reflect its water management state, this study first establishes an internal resistance-operating condition model that considers the coupling effect of temperature and humidity to determine the variation trend of total resistance and stack humidity with single-factor operating conditions. Subsequently, the water management state optimization method based on the ANN-HGPSO algorithm is proposed, which not only quantitatively evaluates the influence weights of different operating conditions on the stack's internal resistance but also efficiently and accurately obtains the optimal combination of five operating conditions: working temperature, anode gas pressure, cathode gas pressure, anode gas humidity, and cathode gas humidity to achieve the optimal water management state in the stack, within the entire range of current densities. Finally, the response surface experimental results of the stack also validate the effectiveness and accuracy of the ANN-HGPSO algorithm. The method mentioned in this article can provide effective strategies for efficient water management and output performance optimization control of PEMFC stacks.
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