| 1. |
- Du, Banghua, et al.
(författare)
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Energy management and performance analysis of an off-grid integrated hydrogen energy utilization system
- 2024
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Ingår i: Energy Conversion and Management. - 0196-8904. ; 299
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Tidskriftsartikel (refereegranskat)abstract
- In integrated hydrogen energy utilization systems, due to the low efficiency of hydrogen/electricity conversion, coordination of energy management and efficient waste heat recovery is required to optimize performance. To address this challenge, this paper presents a comprehensive and sophisticated modeling and energy management strategy to enhance the off-grid energy utilization rate while prolonging the main components' lifetime. The developed model incorporates multiphase flow and heat transport balance for electricity and heat production, enabling a highly accurate representation of real-world behaviors of the system. The proposed off-grid operation strategy is complemented by a designed heat recovery scheme, ensuring the use of energy resources and waste heat. In addition, the proposed energy management strategy monitors the real-time status of each subsystem, actively reducing the number of harmful start-stop cycles of the hydrogen production system, thereby mitigating short-term power impacts and delaying its aging. Specifically, the voltage degradation of the reduction cell is reduced from 4.67 mV to 4.48 mV, the energy utilization rate is increased from 47.6 % to 53.9 %, and the energy efficiency of fuel cells significantly increases from 53.6 % to 78.1 %.
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| 2. |
- Tang, Wei, et al.
(författare)
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17.25% high efficiency ternary solar cells with increased open-circuit voltage using a high HOMO level small molecule guest donor in a PM6:Y6 blend
- 2021
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7496 .- 2050-7488. ; 9:36, s. 20493-20501
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Tidskriftsartikel (refereegranskat)abstract
- A small molecule donor TiC12 with an asymmetric thieno[3,2-c]isochromene unit is incorporated into the PM6:Y6 system as the third component for constructing ternary organic solar cells (OSCs). It was found that TiC12 played an outstanding role in improvement of open-circuit voltage (V-oc), short-circuit current (J(sc)) and fill factor (FF) for the OSCs. The effects of TiC12 on the absorption, exciton dissociation, charge extraction, bimolecular recombination and morphology of the active layer are analyzed in detail. The synergetic improvement of J(sc), V-oc and FF parameters is realized to generate an advanced power conversion efficiency (PCE) of 17.25% in the optimized PM6 : TiC12 : Y6 (0.9 : 0.1 : 1.2) ternary device. Furthermore, the V-oc is increased in proportion to the added amount of TiC12 in the ternary devices due to reduced disorder and nonradiative energy loss, although the guest donor TiC12 exhibited a higher HOMO level than PM6. This study provides an effective and innovative approach to elevate V-oc and thus PCE for ternary OSCs by introducing a guest small molecule donor with a higher HOMO level and better miscibility with the acceptor.
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| 3. |
- Ding, Jiangwei, et al.
(författare)
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All Roads Lead to Rome? : Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
- 2022
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Ingår i: Frontiers in Neurology. - : Frontiers Media S.A.. - 1664-2295. ; 13
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Forskningsöversikt (refereegranskat)abstract
- Background: Dravet syndrome (DS) is a severe epileptic encephalopathy mainly caused by haploinsufficiency of the gene SCN1A, which encodes the voltage-gated sodium channel NaV1. 1 in the brain. While SCN1A mutations are known to be the primary cause of DS, other genes that may cause DS are poorly understood. Several genes with pathogenic mutations result in DS or DS-like phenotypes, which may require different drug treatment approaches. Therefore, it is urgent for clinicians, especially epilepsy specialists to fully understand these genes involved in DS in addition to SCN1A. Particularly for healthcare providers, a deep understanding of these pathogenic genes is useful in properly selecting and adjusting drugs in a more effective and timely manner.Objective: The purpose of this study was to identify genes other than SCN1A that may also cause DS or DS-like phenotypes. Methods: A comprehensive search of relevant Dravet syndrome and severe myoclonic epilepsy in infancy was performed in PubMed, until December 1, 2021. Two independent authors performed the screening for potentially eligible studies. Disagreements were decided by a third, more professional researcher or by all three. The results reported by each study were narratively summarized.Results: A PubMed search yielded 5,064 items, and other sources search 12 records. A total of 29 studies published between 2009 and 2021 met the inclusion criteria. Regarding the included articles, seven studies on PCDH19, three on SCN2A, two on SCN8A, five on SCN1B, two on GABRA1, three on GABRB3, three on GABRG2, and three on STXBP1 were included. Only one study was recorded for CHD2, CPLX1, HCN1 and KCNA2, respectively. It is worth noting that a few articles reported on more than one epilepsy gene.Conclusion: DS is not only identified in variants of SCN1A, but other genes such as PCDH19, SCN2A, SCN8A, SCN1B, GABRA1, GABRB3, GABRG2, KCNA2, CHD2, CPLX1, HCN1A, STXBP1 can also be involved in DS or DS-like phenotypes. As genetic testing becomes more widely available, more genes associated with DS and DS-like phenotypes may be identified and gene-based diagnosis of subtypes of phenotypes in this spectrum may improve the management of these diseases in the future.
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| 4. |
- Liu, Zhengtao, et al.
(författare)
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Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation
- 2020
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Ingår i: Hepatobiliary surgery and nutrition. - : AME Publishing Company. - 2304-3881 .- 2304-389X. ; 9:6, s. 739-758
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Tidskriftsartikel (refereegranskat)abstract
- Background: Liver transplantation (LT) is one of the most effective surgical treatment for patients with end-stage liver disease. Steatosis is a contributor for inferior graft quality. But its impact and safety on transplantation was less assessed in Chinese patients. Methods: Graft steatosis and related information involved in recipients, donors and surgical procedures were retrospectively collected from 239 patients. Results: Donor macrosteatosis (MaS) caused about 2.14 and 2.80 folds of increment on patient and graft mortality. Dose-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10% (P<0.05). Noteworthy, deaths were only observed in MaS group when concurrent with extremely higher post-transplant alanine aminotransferase (ALT, 64%). However, microsteatosis (MiS) grafts didn't affect outcomes after LT. In a cohort of Chinese patients, MaS had comprehensive effects on post-transplant outcomes with relatively lower safety threshold at 10%. Mortality gap caused by MaS grafts was observed in patients with severer ischemia reperfusion injury. Conclusions: Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese patients. Further study is worthy to validate these results and investigate inner mechanism under the phenomenon.
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| 5. |
- Liu, Zhengtao, et al.
(författare)
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Multi-omics network analysis on samples from sequential biopsies reveals vital role of proliferation arrest for Macrosteatosis related graft failure in rats after liver transplantation
- 2023
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Ingår i: Genomics. - : Elsevier BV. - 0888-7543 .- 1089-8646. ; 115:6
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the molecular impact of graft MaS on post-transplant prognosis, based on multi-omics integrative analysis. Rats were fed by methionine-choline deficient diet (MCD) for MaS grafts. Samples were collected from grafts by sequential biopsies. Transcriptomic and metabolomic profilings were assayed. Post-transplant MaS status showed a close association with graft failure. Differentially expressed genes (DEGs) for in-vivo MaS were mainly enriched on pathways of cell cycle and DNA replication. Post-transplant MaS caused arrests of graft regeneration via inhibiting the E2F1 centered network, which was confirmed by an in vitro experiment. Data from metabolomics assays found insufficient serine/creatine which is located on one‑carbon metabolism was responsible for MaS-related GF. Pre-transplant MaS caused severe fibrosis in long-term survivors. DEGs for grafts from long-term survivors with pre-transplant MaS were mainly enriched in pathways of ECM-receptor interaction and focal adhesion. Transcriptional regulatory network analysis confirmed SOX9 as a key transcription factor (TF) for MaS-related fibrosis. Metabolomic assays found elevation of aromatic amino acid (AAA) was a major feature of fibrosis in long-term survivors. Graft MaS in vivo increased post-transplant GF via negative regulations on graft regeneration. Pre-transplant MaS induced severe fibrosis in long-term survivors via activations on ECM-receptor interaction and AAA metabolism.
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| 6. |
- Weng, Zebin, et al.
(författare)
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Performance improvement of variable-angle annular thermoelectric generators considering different boundary conditions
- 2022
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Ingår i: Applied Energy. - : Elsevier BV. - 1872-9118 .- 0306-2619. ; 306
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Tidskriftsartikel (refereegranskat)abstract
- Practical applications of thermoelectric generators are impeded by their low thermoelectric conversion efficiency, and improving the efficiency is vital for the advancements of thermoelectric technology. In this paper, a novel method is proposed for the performance analysis and improvement of the annular thermoelectric generators with variable-angle PN legs (VATEGs). The influence of the PN leg angle on the output performance of the VATEG is investigated by introducing an angle function. Given the volume of the PN legs, the relationship of output performance between the VATEG and traditional constant-angle ATEG (CATEG) is established under different boundary conditions based on a proposed generic model of VATEG. The results are verified numerically using the finite element method. Using the model, it is shown that the output performance of the VATEG is significantly affected by the shape of the PN leg. Finally, the thermal stress on the PN leg is next investigated using a high-fidelity 3D model of the variable-angle PN legs implemented in COMSOL, and it is found that the shape difference has a considerable influence on the thermal stability of VATEG. Under the condition of constant heat flux on the hot side and constant temperature on the cold side of the thermoelectric modules, it shows that when the radius factor is 2, the output performance can be improved by 35% with the designed VATEG, at the expense of 30% higher maximum thermal stress on the PN legs.
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| 7. |
- Yang, Wenlong, et al.
(författare)
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Performance improvement and thermomechanical analysis of a novel asymmetrical annular thermoelectric generator
- 2024
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Ingår i: Applied Thermal Engineering. - 1359-4311. ; 237
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Tidskriftsartikel (refereegranskat)abstract
- Enhancing thermoelectric performance hinges on optimizing the geometry of thermoelectric legs. In this study, we present a novel asymmetrical annular thermoelectric generator (ATEG) in which the proportions of P-type and N-type legs are meticulously balanced. We construct a one-dimensional analytical model tailored to this ATEG. Utilizing this model, we derive the relationship governing thermal-electrical impedance matching in an asymmetrical ATEG and formulate a general expression for optimizing the asymmetry coefficient. We explore the influence of various thermal boundary conditions on optimal impedance matching, ideal annular leg parameters, and the optimal asymmetry coefficient. Our findings reveal that thermal boundary conditions significantly affect the optimal load ratio. Furthermore, in comparison to traditional ATEGs, our proposed asymmetrical ATEG with the optimized structure exhibits a remarkable 16.2 % increase in output power while maintaining the same material volume. Additionally, we perform a three-dimensional numerical analysis of the asymmetrical ATEG using Comsol. Our research findings indicate that introducing the asymmetric structure leads to higher maximum thermal stress on the legs. Interestingly, the study of asymmetric thermal boundary conditions highlights that improving heat transfer between the ATEG and the cooler yields higher mechanical reliability compared to enhancing heat transfer between the ATEG and the heat source.
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