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Sökning: WFRF:(de Giorgio Andrea)

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1.
  • Abelev, Betty, et al. (författare)
  • Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
  • 2012
  • Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
  • Tidskriftsartikel (refereegranskat)abstract
    • We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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3.
  • Abelev, Betty, et al. (författare)
  • Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
  • 2012
  • Ingår i: Journal of High Energy Physics. - 1029-8479. ; :11
  • Tidskriftsartikel (refereegranskat)abstract
    • The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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4.
  • Kehoe, Laura, et al. (författare)
  • Make EU trade with Brazil sustainable
  • 2019
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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5.
  • Klionsky, Daniel J., et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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6.
  • Abercrombie, Daniel, et al. (författare)
  • Dark Matter benchmark models for early LHC Run-2 Searches : Report of the ATLAS/CMS Dark Matter Forum
  • 2020
  • Ingår i: Physics of the Dark Universe. - : Elsevier BV. - 2212-6864. ; 27
  • Tidskriftsartikel (refereegranskat)abstract
    • This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a repository of generator implementations. This report also addresses how to apply the Effective Field Theory formalism for collider searches and present the results of such interpretations.
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7.
  • Menkveld, Albert J., et al. (författare)
  • Nonstandard Errors
  • 2024
  • Ingår i: JOURNAL OF FINANCE. - : Wiley-Blackwell. - 0022-1082 .- 1540-6261. ; 79:3, s. 2339-2390
  • Tidskriftsartikel (refereegranskat)abstract
    • In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty-nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
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8.
  • DeAngelis, Nicola, et al. (författare)
  • 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
  • 2021
  • Ingår i: World Journal of Emergency Surgery. - : BMC. - 1749-7922. ; 16:1
  • Forskningsöversikt (refereegranskat)abstract
    • Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4-1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. These World Society of Emergency Surgery (WSES) guidelines have been produced following an exhaustive review of the current literature and an international expert panel discussion with the aim of providing evidence-based recommendations to facilitate and standardize the detection and management of BDIs during cholecystectomy. In particular, the 2020 WSES guidelines cover the following key aspects: (1) strategies to minimize the risk of BDI during cholecystectomy; (2) BDI rates in general surgery units and review of surgical practice; (3) how to classify, stage, and report BDI once detected; (4) how to manage an intraoperatively detected BDI; (5) indications for antibiotic treatment; (6) indications for clinical, biochemical, and imaging investigations for suspected BDI; and (7) how to manage a postoperatively detected BDI.
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9.
  • Manry, Jérémy, et al. (författare)
  • The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
  • 2022
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:21
  • Tidskriftsartikel (refereegranskat)abstract
    • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
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10.
  • Stolk, Lisette, et al. (författare)
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
  • 2012
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:3, s. 260-268
  • Tidskriftsartikel (refereegranskat)abstract
    • To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.
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11.
  • Arun, K. G., et al. (författare)
  • New horizons for fundamental physics with LISA
  • 2022
  • Ingår i: Living Reviews in Relativity. - : Springer Science and Business Media LLC. - 1433-8351 .- 2367-3613. ; 25:1
  • Forskningsöversikt (refereegranskat)abstract
    • The Laser Interferometer Space Antenna (LISA) has the potential to reveal wonders about the fundamental theory of nature at play in the extreme gravity regime, where the gravitational interaction is both strong and dynamical. In this white paper, the Fundamental Physics Working Group of the LISA Consortium summarizes the current topics in fundamental physics where LISA observations of gravitational waves can be expected to provide key input. We provide the briefest of reviews to then delineate avenues for future research directions and to discuss connections between this working group, other working groups and the consortium work package teams. These connections must be developed for LISA to live up to its science potential in these areas.
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12.
  • Backes, Claudia, et al. (författare)
  • Production and processing of graphene and related materials
  • 2020
  • Ingår i: 2D Materials. - : IOP Publishing. - 2053-1583. ; 7:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present an overview of the main techniques for production and processing of graphene and related materials (GRMs), as well as the key characterization procedures. We adopt a 'hands-on' approach, providing practical details and procedures as derived from literature as well as from the authors' experience, in order to enable the reader to reproduce the results. Section I is devoted to 'bottom up' approaches, whereby individual constituents are pieced together into more complex structures. We consider graphene nanoribbons (GNRs) produced either by solution processing or by on-surface synthesis in ultra high vacuum (UHV), as well carbon nanomembranes (CNM). Production of a variety of GNRs with tailored band gaps and edge shapes is now possible. CNMs can be tuned in terms of porosity, crystallinity and electronic behaviour. Section II covers 'top down' techniques. These rely on breaking down of a layered precursor, in the graphene case usually natural crystals like graphite or artificially synthesized materials, such as highly oriented pyrolythic graphite, monolayers or few layers (FL) flakes. The main focus of this section is on various exfoliation techniques in a liquid media, either intercalation or liquid phase exfoliation (LPE). The choice of precursor, exfoliation method, medium as well as the control of parameters such as time or temperature are crucial. A definite choice of parameters and conditions yields a particular material with specific properties that makes it more suitable for a targeted application. We cover protocols for the graphitic precursors to graphene oxide (GO). This is an important material for a range of applications in biomedicine, energy storage, nanocomposites, etc. Hummers' and modified Hummers' methods are used to make GO that subsequently can be reduced to obtain reduced graphene oxide (RGO) with a variety of strategies. GO flakes are also employed to prepare three-dimensional (3d) low density structures, such as sponges, foams, hydro- or aerogels. The assembly of flakes into 3d structures can provide improved mechanical properties. Aerogels with a highly open structure, with interconnected hierarchical pores, can enhance the accessibility to the whole surface area, as relevant for a number of applications, such as energy storage. The main recipes to yield graphite intercalation compounds (GICs) are also discussed. GICs are suitable precursors for covalent functionalization of graphene, but can also be used for the synthesis of uncharged graphene in solution. Degradation of the molecules intercalated in GICs can be triggered by high temperature treatment or microwave irradiation, creating a gas pressure surge in graphite and exfoliation. Electrochemical exfoliation by applying a voltage in an electrolyte to a graphite electrode can be tuned by varying precursors, electrolytes and potential. Graphite electrodes can be either negatively or positively intercalated to obtain GICs that are subsequently exfoliated. We also discuss the materials that can be amenable to exfoliation, by employing a theoretical data-mining approach. The exfoliation of LMs usually results in a heterogeneous dispersion of flakes with different lateral size and thickness. This is a critical bottleneck for applications, and hinders the full exploitation of GRMs produced by solution processing. The establishment of procedures to control the morphological properties of exfoliated GRMs, which also need to be industrially scalable, is one of the key needs. Section III deals with the processing of flakes. (Ultra)centrifugation techniques have thus far been the most investigated to sort GRMs following ultrasonication, shear mixing, ball milling, microfluidization, and wet-jet milling. It allows sorting by size and thickness. Inks formulated from GRM dispersions can be printed using a number of processes, from inkjet to screen printing. Each technique has specific rheological requirements, as well as geometrical constraints. The solvent choice is critical, not only for the GRM stability, but also in terms of optimizing printing on different substrates, such as glass, Si, plastic, paper, etc, all with different surface energies. Chemical modifications of such substrates is also a key step. Sections IV-VII are devoted to the growth of GRMs on various substrates and their processing after growth to place them on the surface of choice for specific applications. The substrate for graphene growth is a key determinant of the nature and quality of the resultant film. The lattice mismatch between graphene and substrate influences the resulting crystallinity. Growth on insulators, such as SiO2, typically results in films with small crystallites, whereas growth on the close-packed surfaces of metals yields highly crystalline films. Section IV outlines the growth of graphene on SiC substrates. This satisfies the requirements for electronic applications, with well-defined graphene-substrate interface, low trapped impurities and no need for transfer. It also allows graphene structures and devices to be measured directly on the growth substrate. The flatness of the substrate results in graphene with minimal strain and ripples on large areas, allowing spectroscopies and surface science to be performed. We also discuss the surface engineering by intercalation of the resulting graphene, its integration with Si-wafers and the production of nanostructures with the desired shape, with no need for patterning. Section V deals with chemical vapour deposition (CVD) onto various transition metals and on insulators. Growth on Ni results in graphitized polycrystalline films. While the thickness of these films can be optimized by controlling the deposition parameters, such as the type of hydrocarbon precursor and temperature, it is difficult to attain single layer graphene (SLG) across large areas, owing to the simultaneous nucleation/growth and solution/precipitation mechanisms. The differing characteristics of polycrystalline Ni films facilitate the growth of graphitic layers at different rates, resulting in regions with differing numbers of graphitic layers. High-quality films can be grown on Cu. Cu is available in a variety of shapes and forms, such as foils, bulks, foams, thin films on other materials and powders, making it attractive for industrial production of large area graphene films. The push to use CVD graphene in applications has also triggered a research line for the direct growth on insulators. The quality of the resulting films is lower than possible to date on metals, but enough, in terms of transmittance and resistivity, for many applications as described in section V. Transfer technologies are the focus of section VI. CVD synthesis of graphene on metals and bottom up molecular approaches require SLG to be transferred to the final target substrates. To have technological impact, the advances in production of high-quality large-area CVD graphene must be commensurate with those on transfer and placement on the final substrates. This is a prerequisite for most applications, such as touch panels, anticorrosion coatings, transparent electrodes and gas sensors etc. New strategies have improved the transferred graphene quality, making CVD graphene a feasible option for CMOS foundries. Methods based on complete etching of the metal substrate in suitable etchants, typically iron chloride, ammonium persulfate, or hydrogen chloride although reliable, are time- and resource-consuming, with damage to graphene and production of metal and etchant residues. Electrochemical delamination in a low-concentration aqueous solution is an alternative. In this case metallic substrates can be reused. Dry transfer is less detrimental for the SLG quality, enabling a deterministic transfer. There is a large range of layered materials (LMs) beyond graphite. Only few of them have been already exfoliated and fully characterized. Section VII deals with the growth of some of these materials. Amongst them, h-BN, transition metal tri- and di-chalcogenides are of paramount importance. The growth of h-BN is at present considered essential for the development of graphene in (opto) electronic applications, as h-BN is ideal as capping layer or substrate. The interesting optical and electronic properties of TMDs also require the development of scalable methods for their production. Large scale growth using chemical/physical vapour deposition or thermal assisted conversion has been thus far limited to a small set, such as h-BN or some TMDs. Heterostructures could also be directly grown. Section VIII discusses advances in GRM functionalization. A broad range of organic molecules can be anchored to the sp(2) basal plane by reductive functionalization. Negatively charged graphene can be prepared in liquid phase (e.g. via intercalation chemistry or electrochemically) and can react with electrophiles. This can be achieved both in dispersion or on substrate. The functional groups of GO can be further derivatized. Graphene can also be noncovalently functionalized, in particular with polycyclic aromatic hydrocarbons that assemble on the sp(2) carbon network by pi-pi stacking. In the liquid phase, this can enhance the colloidal stability of SLG/FLG. Approaches to achieve noncovalent on-substrate functionalization are also discussed, which can chemically dope graphene. Research efforts to derivatize CNMs are also summarized, as well as novel routes to selectively address defect sites. In dispersion, edges are the most dominant defects and can be covalently modified. This enhances colloidal stability without modifying the graphene basal plane. Basal plane point defects can also be modified, passivated and healed in ultra-high vacuum. The decoration of graphene with metal nanoparticles (NPs) has also received considerable attention, as it allows to exploit synergistic effects between NPs and graphene. Decoration can be either achieved chemically or in the gas phase. All LMs,
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14.
  • Brucalassi, Anna, et al. (författare)
  • A high resolution multi-object spectrograph for the VLT : a pre-concept design
  • 2022
  • Ingår i: Ground-based and Airborne Instrumentation for Astronomy IX. - : SPIE. - 1996-756X .- 0277-786X. - 9781510653498 ; 12184
  • Konferensbidrag (refereegranskat)abstract
    • Following the idea originally proposed during the ESO-Workshop The Very Large Telescope in 2030, the concept of a high resolution spectrograph for the VLT has been further explored, both for the science and technological aspects. Such an instrument will fill a gap in capabilities amongst the landscape of future instrumentation planned for the next decade. Its key characteristic will be high spectral resolution (R = 60000-80000) with multi-object (50-100) capabilities and, possibly, a stability that would provide high radial velocity precision (∼10m/s). In this work, we describe the science cases and driving science requirements for the instrument. Furthermore we will present some design solutions and technical options considered to meet these requirements.
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15.
  • Caligiuri, Vincenzo, et al. (författare)
  • Dry synthesis of bi-layer nanoporous metal films as plasmonic metamaterial
  • 2024
  • Ingår i: Nanophotonics. - : Walter de Gruyter. - 2192-8606 .- 2192-8614. ; 13:7, s. 1159-1167
  • Tidskriftsartikel (refereegranskat)abstract
    • Nanoporous metals are a class of nanostructured materials finding extensive applications in multiple fields thanks to their unique properties attributed to their high surface area and interconnected nanoscale ligaments. They can be prepared following different strategies, but the deposition of an arbitrary pure porous metal is still challenging. Recently, a dry synthesis of nanoporous films based on the plasma treatment of metal thin layers deposited by physical vapour deposition has been demonstrated, as a general route to form pure nanoporous films from a large set of metals. An interesting aspect related to this approach is the possibility to apply the same methodology to deposit the porous films as a multilayer. In this way, it is possible to explore the properties of different porous metals in close contact. As demonstrated in this paper, interesting plasmonic properties emerge in a nanoporous Au–Ag bi-layer. The versatility of the method coupled with the possibility to include many different metals, provides an opportunity to tailor their optical resonances and to exploit the chemical and mechanical properties of components, which is of great interest to applications ranging from sensing, to photochemistry and photocatalysis.
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16.
  • Cornford, Philip, et al. (författare)
  • EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer-2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent.
  • 2024
  • Ingår i: European urology. - 1873-7560.
  • Tidskriftsartikel (refereegranskat)abstract
    • The European Association of Urology (EAU)-European Association of Nuclear Medicine (EANM)-European Society for Radiotherapy and Oncology (ESTRO)-European Society of Urogenital Radiology (ESUR)-International Society of Urological Pathology (ISUP)-International Society of Geriatric Oncology (SIOG) guidelines provide recommendations for the management of clinically localised prostate cancer (PCa). This paper aims to present a summary of the 2024 version of the EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on the screening, diagnosis, and treatment of clinically localised PCa.The panel performed a literature review of all new data published in English, covering the time frame between May 2020 and 2023. The guidelines were updated, and a strength rating for each recommendation was added based on a systematic review of the evidence.A risk-adapted strategy for identifying men who may develop PCa is advised, generally commencing at 50yr of age and based on individualised life expectancy. The use of multiparametric magnetic resonance imaging in order to avoid unnecessary biopsies is recommended. When a biopsy is considered, a combination of targeted and regional biopsies should be performed. Prostate-specific membrane antigen positron emission tomography imaging is the most sensitive technique for identifying metastatic spread. Active surveillance is the appropriate management for men with low-risk PCa, as well as for selected favourable intermediate-risk patients with International Society of Urological Pathology grade group 2 lesions. Local therapies are addressed, as well as the management of persistent prostate-specific antigen after surgery. A recommendation to consider hypofractionation in intermediate-risk patients is provided. Patients with cN1 PCa should be offered a local treatment combined with long-term intensified hormonal treatment.The evidence in the field of diagnosis, staging, and treatment of localised PCa is evolving rapidly. These PCa guidelines reflect the multidisciplinary nature of PCa management.This article is the summary of the guidelines for "curable" prostate cancer. Prostate cancer is "found" through a multistep risk-based screening process. The objective is to find as many men as possible with a curable cancer. Prostate cancer is curable if it resides in the prostate; it is then classified into low-, intermediary-, and high-risk localised and locally advanced prostate cancer. These risk classes are the basis of the treatments. Low-risk prostate cancer is treated with "active surveillance", a treatment with excellent prognosis. For low-intermediary-risk active surveillance should also be discussed as an option. In other cases, active treatments, surgery, or radiation treatment should be discussed along with the potential side effects to allow shared decision-making.
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17.
  • Corradini, Flavio, et al. (författare)
  • Tangramob : An Agent-Based Simulation Framework for Validating Urban Smart Mobility Solutions
  • 2020
  • Ingår i: Journal of Intelligent Systems. - : WALTER DE GRUYTER GMBH. - 0334-1860 .- 2191-026X. ; 29:1, s. 1188-1201
  • Tidskriftsartikel (refereegranskat)abstract
    • Estimating the effects of introducing a range of smart mobility solutions within an urban area is a crucial concern in urban planning. The lack of a simulator for the assessment of mobility initiatives forces local public authorities and mobility service providers to base their decisions on guidelines derived from common heuristics and best practices. These approaches can help planners in shaping mobility solutions; however, given the high number of variables to consider, the effects are not guaranteed. Therefore, a solution conceived respecting the available guidelines can result in a failure in a different context. In particular, difficult aspects to consider are the interactions between different mobility services available in a given urban area and the acceptance of a given mobility initiative by the inhabitants of the area. In order to fill this gap, we introduce Tangramob, an agent-based simulation framework capable of assessing the impacts of a smart mobility initiative within an urban area of interest. Tangramob simulates how urban traffic is expected to evolve as citizens start experiencing newly offered traveling solutions. This allows decision makers to evaluate the efficacy of their initiatives, taking into account the current urban system. In this paper, we provide an overview of the simulation framework along with its design. To show the potential of Tangramob, three mobility initiatives are simulated and compared in the same scenario. This demonstrates how it is possible to perform comparative experiments so as to align mobility initiatives to the user goals.
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18.
  • Loza, M. J., et al. (författare)
  • Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
  • 2016
  • Ingår i: Respiratory Research. - : Springer Nature. - 1465-9921 .- 1465-993X. ; 17:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to define and validate, for the first time ever, clinically driven asthma phenotypes using two independent, severe asthma cohorts: ADEPT and U-BIOPRED. Methods: Fuzzy partition-around-medoid clustering was performed on pre-specified data from the ADEPT participants (n = 156) and independently on data from a subset of U-BIOPRED asthma participants (n = 82) for whom the same variables were available. Models for cluster classification probabilities were derived and applied to the 12-month longitudinal ADEPT data and to a larger subset of the U-BIOPRED asthma dataset (n = 397). High and low type-2 inflammation phenotypes were defined as high or low Th2 activity, indicated by endobronchial biopsies gene expression changes downstream of IL-4 or IL-13. Results: Four phenotypes were identified in the ADEPT (training) cohort, with distinct clinical and biomarker profiles. Phenotype 1 was "mild, good lung function, early onset", with a low-inflammatory, predominantly Type-2, phenotype. Phenotype 2 had a "moderate, hyper-responsive, eosinophilic" phenotype, with moderate asthma control, mild airflow obstruction and predominant Type-2 inflammation. Phenotype 3 had a "mixed severity, predominantly fixed obstructive, non-eosinophilic and neutrophilic" phenotype, with moderate asthma control and low Type-2 inflammation. Phenotype 4 had a "severe uncontrolled, severe reversible obstruction, mixed granulocytic" phenotype, with moderate Type-2 inflammation. These phenotypes had good longitudinal stability in the ADEPT cohort. They were reproduced and demonstrated high classification probability in two subsets of the U-BIOPRED asthma cohort. Conclusions: Focusing on the biology of the four clinical independently-validated easy-to-assess ADEPT asthma phenotypes will help understanding the unmet need and will aid in developing tailored therapies. Trial registration:NCT01274507(ADEPT), registered October 28, 2010 and NCT01982162(U-BIOPRED), registered October 30, 2013.
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19.
  • Marra, Giancarlo, et al. (författare)
  • Impact of Epithelial Histological Types, Subtypes, and Growth Patterns on Oncological Outcomes for Patients with Nonmetastatic Prostate Cancer Treated with Curative Intent: A Systematic Review.
  • 2023
  • Ingår i: European urology. - 0302-2838 .- 1873-7560. ; 84:1, s. 65-85
  • Tidskriftsartikel (refereegranskat)abstract
    • The optimal management for men with prostate cancer (PCa) with unconventional histology (UH) is unknown. The outcome for these cancers might be worse than for conventional PCa and so different approaches may be needed.To compare oncological outcomes for conventional and UH PCa in men with localized disease treated with curative intent.A systematic review adhering to the Referred Reporting Items for Systematic Reviews and Meta-Analyses was prospectively registered on PROSPERO (CRD42022296013) was performed in July 2021.We screened 3651 manuscripts and identified 46 eligible studies (reporting on 1871814 men with conventional PCa and 6929 men with 10 different PCa UHs). Extraprostatic extension and lymph node metastases, but not positive margin rates, were more common with UH PCa than with conventional tumors. PCa cases with cribriform pattern, intraductal carcinoma, or ductal adenocarcinoma had higher rates of biochemical recurrence and metastases after radical prostatectomy than for conventional PCa cases. Lower cancer-specific survival rates were observed for mixed cribriform/intraductal and cribriform PCa. By contrast, pathological findings and oncological outcomes for mucinous and prostatic intraepithelial neoplasia (PIN)-like PCa were similar to those for conventional PCa. Limitations of this review include low-quality studies, a risk of reporting bias, and a scarcity of studies that included radiotherapy.Intraductal, cribriform, and ductal UHs may have worse oncological outcomes than for conventional and mucinous or PIN-like PCa. Alternative treatment approaches need to be evaluated in men with these cancers.We reviewed the literature to explore whether prostate cancers with unconventional growth patterns behave differently to conventional prostate cancers. We found that some unconventional growth patterns have worse outcomes, so we need to investigate if they need different treatments. Urologists should be aware of these growth patterns and their clinical impact.
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20.
  • Matuozzo, Daniela, et al. (författare)
  • Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.
  • 2023
  • Ingår i: Genome medicine. - 1756-994X. ; 15:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in~80% of cases.We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1×10-4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1×10-4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4×10-3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7×10-8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68×10-5).Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60years old.
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21.
  • Oestreicher, Ursula, et al. (författare)
  • RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA)
  • 2017
  • Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 93:1, s. 20-29
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: Two quality controlled inter-laboratory exercises were organized within the EU project 'Realizing the European Network of Biodosimetry (RENEB)' to further optimize the dicentric chromosome assay (DCA) and to identify needs for training and harmonization activities within the RENEB network. Materials and methods: The general study design included blood shipment, sample processing, analysis of chromosome aberrations and radiation dose assessment. After manual scoring of dicentric chromosomes in different cell numbers dose estimations and corresponding 95% confidence intervals were submitted by the participants. Results: The shipment of blood samples to the partners in the European Community (EU) were performed successfully. Outside the EU unacceptable delays occurred. The results of the dose estimation demonstrate a very successful classification of the blood samples in medically relevant groups. In comparison to the 1st exercise the 2nd intercomparison showed an improvement in the accuracy of dose estimations especially for the high dose point. Conclusions: In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA. The performance of the RENEB network as a whole has clearly benefited from harmonization processes and specific training activities for the network partners.
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22.
  • Paciaroni, Maurizio, et al. (författare)
  • Early recurrence in paroxysmal versus sustained atrial fibrillation in patients with acute ischaemic stroke.
  • 2019
  • Ingår i: European stroke journal. - : SAGE Publications. - 2396-9881 .- 2396-9873. ; 4:1, s. 55-64
  • Tidskriftsartikel (refereegranskat)abstract
    • The relationship between different patterns of atrial fibrillation and early recurrence after an acute ischaemic stroke is unclear.In a prospective cohort study, we evaluated the rates of early ischaemic recurrence after an acute ischaemic stroke in patients with paroxysmal atrial fibrillation or sustained atrial fibrillation which included persistent and permanent atrial fibrillation.In patients with acute ischaemic stroke, atrial fibrillation was categorised as paroxysmal atrial fibrillation or sustained atrial fibrillation. Ischaemic recurrences were the composite of ischaemic stroke, transient ischaemic attack and symptomatic systemic embolism occurring within 90 days from acute index stroke.A total of 2150 patients (1155 females, 53.7%) were enrolled: 930 (43.3%) had paroxysmal atrial fibrillation and 1220 (56.7%) sustained atrial fibrillation. During the 90-day follow-up, 111 ischaemic recurrences were observed in 107 patients: 31 in patients with paroxysmal atrial fibrillation (3.3%) and 76 with sustained atrial fibrillation (6.2%) (hazard ratio (HR) 1.86 (95% CI 1.24-2.81)). Patients with sustained atrial fibrillation were on average older, more likely to have diabetes mellitus, hypertension, history of stroke/ transient ischaemic attack, congestive heart failure, atrial enlargement, high baseline NIHSS-score and implanted pacemaker. After adjustment by Cox proportional hazard model, sustained atrial fibrillation was not associated with early ischaemic recurrences (adjusted HR 1.23 (95% CI 0.74-2.04)).After acute ischaemic stroke, patients with sustained atrial fibrillation had a higher rate of early ischaemic recurrence than patients with paroxysmal atrial fibrillation. After adjustment for relevant risk factors, sustained atrial fibrillation was not associated with a significantly higher risk of recurrence, thus suggesting that the risk profile associated with atrial fibrillation, rather than its pattern, is determinant for recurrence.
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23.
  • Soffitta, Paolo, et al. (författare)
  • XIPE : the X-ray imaging polarimetry explorer
  • 2013
  • Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 36:3, s. 523-567
  • Tidskriftsartikel (refereegranskat)abstract
    • X-ray polarimetry, sometimes alone, and sometimes coupled to spectral and temporal variability measurements and to imaging, allows a wealth of physical phenomena in astrophysics to be studied. X-ray polarimetry investigates the acceleration process, for example, including those typical of magnetic reconnection in solar flares, but also emission in the strong magnetic fields of neutron stars and white dwarfs. It detects scattering in asymmetric structures such as accretion disks and columns, and in the so-called molecular torus and ionization cones. In addition, it allows fundamental physics in regimes of gravity and of magnetic field intensity not accessible to experiments on the Earth to be probed. Finally, models that describe fundamental interactions (e.g. quantum gravity and the extension of the Standard Model) can be tested. We describe in this paper the X-ray Imaging Polarimetry Explorer (XIPE), proposed in June 2012 to the first ESA call for a small mission with a launch in 2017. The proposal was, unfortunately, not selected. To be compliant with this schedule, we designed the payload mostly with existing items. The XIPE proposal takes advantage of the completed phase A of POLARIX for an ASI small mission program that was cancelled, but is different in many aspects: the detectors, the presence of a solar flare polarimeter and photometer and the use of a light platform derived by a mass production for a cluster of satellites. XIPE is composed of two out of the three existing JET-X telescopes with two Gas Pixel Detectors (GPD) filled with a He-DME mixture at their focus. Two additional GPDs filled with a 3-bar Ar-DME mixture always face the Sun to detect polarization from solar flares. The Minimum Detectable Polarization of a 1 mCrab source reaches 14 % in the 2-10 keV band in 10(5) s for pointed observations, and 0.6 % for an X10 class solar flare in the 15-35 keV energy band. The imaging capability is 24 arcsec Half Energy Width (HEW) in a Field of View of 14.7 arcmin x 14.7 arcmin. The spectral resolution is 20 % at 6 keV and the time resolution is 8 mu s. The imaging capabilities of the JET-X optics and of the GPD have been demonstrated by a recent calibration campaign at PANTER X-ray test facility of the Max-Planck-Institut fur extraterrestrische Physik (MPE, Germany). XIPE takes advantage of a low-earth equatorial orbit with Malindi as down-link station and of a Mission Operation Center (MOC) at INPE (Brazil). The data policy is organized with a Core Program that comprises three months of Science Verification Phase and 25 % of net observing time in the following 2 years. A competitive Guest Observer program covers the remaining 75 % of the net observing time.
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24.
  • Antonenko, Kateryna, et al. (författare)
  • Sex-related differences in risk factors, type of treatment received and outcomes in patients with atrial fibrillation and acute stroke: Results from the RAF-study (Early Recurrence and Cerebral Bleeding in Patients with Acute Ischemic Stroke and Atrial Fibrillation)
  • 2017
  • Ingår i: European Stroke Journal. - : SAGE Publications. - 2396-9873 .- 2396-9881. ; 2:1, s. 46-53
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Atrial fibrillation is an independent risk factor of thromboembolism. Women with atrial fibrillation are at a higher overall risk for stroke compared to men with atrial fibrillation. The aim of this study was to evaluate for sex differences in patients with acute stroke and atrial fibrillation, regarding risk factors, treatments received and outcomes. Methods: Data were analyzed from the ‘‘Recurrence and Cerebral Bleeding in Patients with Acute Ischemic Stroke and Atrial Fibrillation’’ (RAF-study), a prospective, multicenter, international study including only patients with acute stroke and atrial fibrillation. Patients were followed up for 90 days. Disability was measured by the modified Rankin Scale (0–2 favorable outcome, 3–6 unfavorable outcome). Results: Of the 1029 patients enrolled, 561 were women (54.5%) (p<0.001) and younger (p<0.001) compared to men. In patients with known atrial fibrillation, women were less likely to receive oral anticoagulants before index stroke (p¼0.026) and were less likely to receive anticoagulants after stroke (71.3% versus 78.4%, p¼0.01). There was no observed sex difference regarding the time of starting anticoagulant therapy between the two groups (6.411.7 days for men versus 6.512.4 days for women, p¼0.902). Men presented with more severe strokes at onset (mean NIHSS 9.26.9 versus 8.17.5, p<0.001). Within 90 days, 46 (8.2%) recurrent ischemic events (stroke/TIA/systemic embolism) and 19 (3.4%) symptomatic cerebral bleedings were found in women compared to 30 (6.4%) and 18 (3.8%) in men (p¼0.28 and p¼0.74). At 90 days, 57.7% of women were disabled or deceased, compared to 41.1% of the men (p<0.001). Multivariate analysis did not confirm this significance. Conclusions: Women with atrial fibrillation were less likely to receive oral anticoagulants prior to and after stroke compared to men with atrial fibrillation, and when stroke occurred, regardless of the fact that in our study women were younger and with less severe stroke, outcomes did not differ between the sexes.
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25.
  • Buwaider, Ali, et al. (författare)
  • Extended reality in cranial and spinal neurosurgery : a bibliometric analysis
  • 2024
  • Ingår i: Acta Neurochirurgica. - : Springer. - 0001-6268 .- 0942-0940. ; 166:1
  • Forskningsöversikt (refereegranskat)abstract
    • PURPOSE: This bibliometric analysis of the top 100 cited articles on extended reality (XR) in neurosurgery aimed to reveal trends in this research field. Gender differences in authorship and global distribution of the most-cited articles were also addressed.METHODS: A Web of Science electronic database search was conducted. The top 100 most-cited articles related to the scope of this review were retrieved and analyzed for trends in publications, journal characteristics, authorship, global distribution, study design, and focus areas. After a brief description of the top 100 publications, a comparative analysis between spinal and cranial publications was performed.RESULTS: From 2005, there was a significant increase in spinal neurosurgery publications with a focus on pedicle screw placement. Most articles were original research studies, with an emphasis on augmented reality (AR). In cranial neurosurgery, there was no notable increase in publications. There was an increase in studies assessing both AR and virtual reality (VR) research, with a notable emphasis on VR compared to AR. Education, surgical skills assessment, and surgical planning were more common themes in cranial studies compared to spinal studies. Female authorship was notably low in both groups, with no significant increase over time. The USA and Canada contributed most of the publications in the research field.CONCLUSIONS: Research regarding the use of XR in neurosurgery increased significantly from 2005. Cranial research focused on VR and resident education while spinal research focused on AR and neuronavigation. Female authorship was underrepresented. North America provides most of the high-impact research in this area.
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26.
  • Buwaider, Ali, et al. (författare)
  • Extended reality in cranial and spinal neurosurgery – a bibliometric analysis
  • 2024
  • Ingår i: Acta Neurochirurgica. - : Springer Nature. - 0001-6268 .- 0942-0940. ; 166:1
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose: This bibliometric analysis of the top 100 cited articles on extended reality (XR) in neurosurgery aimed to reveal trends in this research field. Gender differences in authorship and global distribution of the most-cited articles were also addressed. Methods: A Web of Science electronic database search was conducted. The top 100 most-cited articles related to the scope of this review were retrieved and analyzed for trends in publications, journal characteristics, authorship, global distribution, study design, and focus areas. After a brief description of the top 100 publications, a comparative analysis between spinal and cranial publications was performed. Results: From 2005, there was a significant increase in spinal neurosurgery publications with a focus on pedicle screw placement. Most articles were original research studies, with an emphasis on augmented reality (AR). In cranial neurosurgery, there was no notable increase in publications. There was an increase in studies assessing both AR and virtual reality (VR) research, with a notable emphasis on VR compared to AR. Education, surgical skills assessment, and surgical planning were more common themes in cranial studies compared to spinal studies. Female authorship was notably low in both groups, with no significant increase over time. The USA and Canada contributed most of the publications in the research field. Conclusions: Research regarding the use of XR in neurosurgery increased significantly from 2005. Cranial research focused on VR and resident education while spinal research focused on AR and neuronavigation. Female authorship was underrepresented. North America provides most of the high-impact research in this area.
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27.
  • de Giorgio, Andrea, Dr Eng., et al. (författare)
  • Adopting extended reality? : A systematic review of manufacturing training and teaching applications
  • 2023
  • Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 71, s. 645-663
  • Tidskriftsartikel (refereegranskat)abstract
    • The training of future experts and operators in manufacturing engineering relies on understanding procedural processes that require applied practice. Yet, current manufacturing education and training overwhelmingly continues to depend on traditional pedagogical methods that segregate theoretical studies and practical training. While educational institutes have generally improved theoretical studies, they often lack facilities and labs to properly reproduce the working environments necessary for practice. Even in industrial settings, it is difficult, if not impossible, to halt the actual production lines to train new operators. Recently, applications with extended reality (XR) technologies, such as virtual, augmented, or mixed reality, reached a mature technology readiness level. With this technological advancement, we can envision a transition to a new teaching paradigm that exploits simulated learning environments. Thus, it becomes possible to bridge the gap between theory and practice for both students and industrial trainees. This article presents a systematic literature review of the main applications of XR technologies in manufacturing education, their goals and technology readiness levels, and a comprehensive overview of the development tools and experimental strategies deployed. This review contributes: (1) a state-of-the-art description of current research in XR education for manufacturing systems, and (2) a comprehensive analysis of the technological platforms, the experimental procedures and the analytical methodologies deployed in the body of literature examined. It serves as a guide for setting up and executing experimental designs for evaluating interventions of XR in manufacturing education and training.
  •  
28.
  • de Giorgio, Andrea, et al. (författare)
  • Artificial intelligence control in 4D cylindrical space for industrial robotic applications
  • 2020
  • Ingår i: IEEE Access. - 2169-3536. ; 8, s. 174833-174844
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper argues that an efficient artificial intelligence control algorithm needs the built-in symmetries of an industrial robot manipulator to be further characterized and exploited. The product of this enhancement is a four-dimensional (4D) discrete cylindrical grid space that can directly replace complex robot models. A* is chosen for its wide use among such algorithms to study the advantages and disadvantages of steering the robot manipulator within the 4D cylindrical discrete grid. The study shows that this approach makes it possible to control a robot without any specific knowledge of the robot kinematic and dynamic models at planning and execution time. In fact, the robot joint positions for each grid cell are pre-calculated and stored as knowledge, then quickly retrieved by the pathfinding algorithm when needed. The 4D cylindrical discrete space has both the advantages of the configuration space and the three-dimensional Cartesian workspace of the robot. Since path optimization is the core of any search algorithms, including A*, the 4D cylindrical grid provides for a search space that can embed further knowledge in form of cell properties, including the presence of obstacles and volumetric occupancy of the entire industrial robot body for obstacle avoidance applications. The main trade-off is between a limited capacity for pre-computed grid knowledge and the path search speed. This innovative approach encourages the use of search algorithms for industrial robotic applications, opens up to the study of other robot symmetries present in different robot models and lays a foundation for the application of dynamic obstacle avoidance algorithms.
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29.
  • de Giorgio, Andrea, Dr Eng., et al. (författare)
  • Assessing the influence of expert video aid on assembly learning curves
  • 2021
  • Tidskriftsartikel (refereegranskat)abstract
    • Since the introduction of the concept of learning curves in manufacturing, many articles have been applying the model to study learning phenomena. In assembly, several studies present a learning curve when an operator is trained over a new assembly task; however, when comparisons are made between learning curves corresponding to different training methods, unaware researchers can show misleading results. Often, these studies neglect either or both the stochastic nature of the learning curves produced by several operators under experimental conditions, and the high correlation of the experimental samples collected from each operator that constitute one learning curve. Furthermore, recent studies are testing newer technologies, such as assembly animations or augmented reality, to provide assembly aid, but they fail to observe deeper implications on how these digital training methods truly influence the learning curves of the operators. This article proposes a novel statistical study of the influence of expert video aid on the learning curves in terms of assembly time by means of functional analysis of variance (FANOVA). This method is better suited to compare learning curves than common analysis of variance (ANOVA), due to correlated data, or graphical comparisons, due to the stochastic nature of the aggregated learning curves. The results show that two main effects of the expert video aid influence the learning curves: one in the transient and another in the steady state of the learning curve. The transient effect of the expert video aid, where the statistical tests suffer from a high variance in the data, appears to be a reduction in terms of assembly time for the first assemblies: the operators seem to benefit from the expert video aid. As soon as the steady state is reached, a slower and statistically significant effect appears to favor the learning processes of the operators who do not receive any training aid. Since the steady state of the learning curves represents the long term production efficiency of the operators, the latter effect might require more attention from industry and researchers.
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30.
  • de Giorgio, Andrea, Dr Eng., et al. (författare)
  • Assessing the influence of expert video aid on assembly learning curves
  • 2022
  • Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 62, s. 263-269
  • Tidskriftsartikel (refereegranskat)abstract
    • Since the introduction of the concept of learning curves in manufacturing, many articles have been applying the model to study learning phenomena. In assembly, several studies present a learning curve when an operator is trained over a new assembly task; however, when comparisons are made between learning curves corresponding to different training methods, unaware researchers can show misleading results. Often, these studies neglect either or both the stochastic nature of the learning curves produced by several operators under experimental conditions, and the high correlation of the experimental samples collected from each operator that constitute one learning curve. Furthermore, recent studies are testing newer technologies, such as assembly animations or augmented reality, to provide assembly aid, but they fail to observe deeper implications on how these digital training methods truly influence the learning curves of the operators. This article proposes a novel statistical study of the influence of expert video aid on the learning curves in terms of assembly time by means of functional analysis of variance (FANOVA). This method is better suited to compare learning curves than common analysis of variance (ANOVA), due to correlated data, or graphical comparisons, due to the stochastic nature of the aggregated learning curves. The results show that two main effects of the expert video aid influence the learning curves: one in the transient and another in the steady state of the learning curve. The transient effect of the expert video aid, where the statistical tests suffer from a high variance in the data, appears to be a reduction in terms of assembly time for the first assemblies: the operators seem to benefit from the expert video aid. As soon as the steady state is reached, a slower and statistically significant effect appears to favor the learning processes of the operators who do not receive any training aid. Since the steady state of the learning curves represents the long term production efficiency of the operators, the latter effect might require more attention from industry and researchers.
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31.
  • de Giorgio, Andrea, Dr Eng. (författare)
  • Citation review of a hybridization of genetic algorithms and fuzzy logic for the single-machine scheduling with flexible maintenance problem under human resource constraints by Touat et al.
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • This article is a citation review of the publication "A hybridization of genetic algorithms and fuzzy logic for the single-machine scheduling with flexible maintenance problem under human resource constraints" published in 2017 by Touat et al. in Applied Soft Computing. A citation review is a widely neglected scientific method, refined by de Giorgio and Onori in 2020, to produce useful insights on research articles from their citing works after a few years from the publication date. At the time of this review, July 2021, corresponding to a four-year period, the largest citation record belongs to Google Scholar that reports twenty articles citing the original work. A total of twenty-one citing articles is found in literature databases. The citation review shows that the work of Touat et al. is much appreciated as an example of the use of fuzzy algorithms to deal with uncertainties, especially in scheduling problems. Few of the citing articles offer extensive insights in alternative or improved future work scenarios. This citation review can help Touat et al. and other researchers working on similar research topics to aim towards those community-requested research directions.
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32.
  • de Giorgio, Andrea, Dr Eng., et al. (författare)
  • Citation review of Human-Machine Collaboration in Virtual Reality for Adaptive Production Engineering by de Giorgio et al.
  • 2024
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • This article argues that despite a citation review is a rarely used research tool, this can be very useful to assess the impact of new research topics, both from the future research direction and the bibliometric perspectives. An explorative study is presented around the research area marked as Industry 4.0 with the conference paper mentioned in the title of this citation review. Even though the given reference paper is relatively recent, there are already twenty-seven citations listed among three different scholar databases. These are Google Scholar, ResearchGate and Semantic Scholar. In light of this, the article provides a bibliometric confirmation and analysis for the progression of the line of research adopted by de Giorgio et al. in the exploration of non-traditional methods using virtual reality technology and human-robot collaboration for adaptive applications in Industry 4.0. Furthermore, it represents a model for the authors’ self-development and an example of an unconventional approach to scientific work that may help improve related bibliometric research and scholar database strategies to index new articles and topics in the future.
  •  
33.
  • de Giorgio, Andrea, et al. (författare)
  • Human-machine Collaboration in Virtual Reality for Adaptive Production Engineering
  • 2017
  • Ingår i: Procedia Manufacturing. - : Elsevier BV. - 2351-9789. ; 11, s. 1279-1287
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper outlines the main steps towards an open and adaptive simulation method for human-robot collaboration (HRC) in production engineering supported by virtual reality (VR). The work is based on the latest software developments in the gaming industry, in addition to the already commercially available hardware that is robust and reliable. This allows to overcome VR limitations of the industrial software provided by manufacturing machine producers and it is based on an open-source community programming approach and also leads to significant advantages such as interfacing with the latest developed hardware for realistic user experience in immersive VR, as well as the possibility to share adaptive algorithms. A practical implementation in Unity is provided as a functional prototype for feasibility tests. However, at the time of this paper, no controlled human-subject studies on the implementation have been noted, in fact, this is solely provided to show preliminary proof of concept. Future work will formally address the questions that are raised in this first run.
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34.
  • de Giorgio, Andrea, Dr Eng. 1987- (författare)
  • Introducing a procedural knowledge model for enhancing industrial process adaptiveness
  • 2021
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Industrial processes are mainly based on procedural knowledge that must be continually elicited from experienced operators and learned by novice operators. In the context of Industry 4.0, machines already play a key role in knowledge transfer; however, new models and methods based on the artificial intelligence advances of the past few years need to be developed and applied. The future of human-machine collaboration is not limited to physical applications, but it has the potential to harness both the strength of human skills, experience and the computational power provided by the surrounding machines for truly adaptive industrial processes. The winning recipe is a balance between letting humans exploit their inherent experience and letting machines integrate the missing skills to preserve production standards. This work introduces a procedural knowledge model to be used for the design of industrial and scientific adaptive processes and it paves the way to transforming human-machine collaboration into an efficient solution to make industrial and scientific processes resilient to a constantly changing world.
  •  
35.
  • de Giorgio, Andrea, Dr Eng., et al. (författare)
  • Measuring the effect of automatically authored video aid on assembly time for procedural knowledge transfer among operators in adaptive assembly stations
  • 2021
  • Ingår i: International Journal of Production Research. - : Informa UK Limited. - 0020-7543 .- 1366-588X.
  • Tidskriftsartikel (refereegranskat)abstract
    • Can automatically-authored videos of industrial operators help other operators to learn procedural tasks? This question is relevant to the advent of the industrial internet of things (IIoT) and Industry 4.0, where smart machines to help human operators rather than replacing them, in order to benefit from the best of humans and machines. The study considers an industrial ecosystem where procedural knowledge (PK) is quickly and effectively transferred from one operator to another. Assembly tasks are procedural in nature and present a certain complexity that still does not allow machines and their sensors to capture all the details of the operations. Especially if the assembly operation is adaptive and not fixed in terms of assembly sequence plan. In order to help the operators, videos of other operators executing the complex procedural tasks can be automatically recorded and authored from machines. This study shows by means of statistical design and analysis of experiments that expert aid, provided before each subassembly, can reduce the assembly time of an untrained operator, whereas automatically authored video aids can transfer PK but producing an opposite effect on the assembly time. Therefore, hybrid training methods are still necessary and trade-offs have to be considered. Managerial insights from the results suggest an unneglectable impact of the choice to digitize industrial operations too early. The experimental studies presented can act as guidelines for the correct statistical testing of innovative solutions in industry.
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36.
  • de Giorgio, Andrea, et al. (författare)
  • Procedural knowledge and function blocks for smart process planning
  • 2020
  • Ingår i: Procedia Manufacturing. - Stockholm : Elsevier. - 2351-9789. ; 48, s. 1079-1087
  • Tidskriftsartikel (refereegranskat)abstract
    • In the age of digital manufacturing there is a need to elicit and transfer procedural knowledge between humans and machines. Having proper knowledge is essential in decision-making. The more the knowledge, the better decisions are made. To capture experiences and turn them into knowledge is fundamental in learning processes and knowledge development. Knowledge engineering and knowledge management have been subject for research for decades and several concepts about knowledge and knowledge transfer have been introduced, but a functional approach to exploit knowledge efficiently in manufacturing is still missing. In the era of Industry 4.0, humans and machines must be able to collaborate in such way that both can exploit the best abilities of each other in a manufacturing process. This paper introduces a procedural knowledge process (PKP) approach to capturing and defining unexpected events, while a process step is able to perform its required functions and transfer that information as machine-understandable knowledge about a failure mode. Function blocks (FBs), as per the IEC-61499 standard, have been proposed as a way to achieve distributed process planning in which the manufacturing process can adapt itself to runtime conditions, e.g. machine availability, etc. However, FBs are event-driven systems and the approach is limited to work under well-known runtime conditions, e.g. machine configurations and states, or deviations which are impossible to foresee in advance, for instance the outcome of a process failure mode effects analysis (PFMEA). The PKP introduced in this paper, aims at bridging this gap by integrating at runtime an expert operator’s solution based on root cause analysis (RCA) in an FB architecture, making the FB knowledge-driven systems, for further executions of the same without redesigning it. Natural language representations of procedural knowledge blocks (PKBs) allow to transfer procedural knowledge to human operators, i.e. explain the process flow of a machine decision, while machine representations of PKBs allow to embed procedural knowledge that is elicited from expert operators upon unexpected events into the FBs process. The resulting PKP enhances the FBs for smart industrial applications, such as the process planning use case described in this paper.
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37.
  • de Giorgio, Andrea, et al. (författare)
  • Systematic review of class imbalance problems in manufacturing
  • 2023
  • Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 71, s. 620-644
  • Forskningsöversikt (refereegranskat)abstract
    • Class imbalance (CI) is a well-known problem in data science. Nowadays, it is affecting the data modeling of many of the real-world processes that are being digitized. The manufacturing industry turns out to be highly affected by this problem, especially in fault inspection, prediction or monitoring processes, and in all those processes where the production efficiency is high and the data samples of anomalous events are rare. In this work, we systematically review all the data manipulation, machine learning or deep learning solutions to the CI problem in the manufacturing domain. We also critically evaluate all the different metrics that researchers can compare in order to estimate the improvements carried by their proposed solutions, and we look at the availability of public source code and data-imbalanced datasets that can be used for benchmarking. Finally, we summarize the most applied solutions to the CI problem in manufacturing and we look at future challenges. While posing a reference for the best practices at the time of this review, we challenge researchers to standardize the use of data science algorithms for CI in the manufacturing domain.
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38.
  • de Giorgio, Andrea, Dr Eng., et al. (författare)
  • Towards online reinforced learning of assembly sequence planning with interactive guidance systems for industry 4.0 adaptive manufacturing
  • 2021
  • Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 60, s. 22-34
  • Tidskriftsartikel (refereegranskat)abstract
    • Literature shows that reinforcement learning (RL) and the well-known optimization algorithms derived from it have been applied to assembly sequence planning (ASP); however, the way this is done, as an offline process, ends up generating optimization methods that are not exploiting the full potential of RL. Today’s assembly lines need to be adaptive to changes, resilient to errors and attentive to the operators’ skills and needs. If all of these aspects need to evolve towards a new paradigm, called Industry 4.0, the way RL is applied to ASP needs to change as well: the RL phase has to be part of the assembly execution phase and be optimized with time and several repetitions of the process. This article presents an agile exploratory experiment in ASP to prove the effectiveness of RL techniques to execute ASP as an adaptive, online and experience-driven optimization process, directly at assembly time. The human-assembly interaction is modelled through the input-outputs of an assembly guidance system built as an assembly digital twin. Experimental assemblies are executed without pre-established assembly sequence plans and adapted to the operators’ needs. The experiments show that precedence and transition matrices for an assembly can be generated from the statistical knowledge of several different assembly executions. When the frequency of a given subassembly reinforces its importance, statistical results obtained from the experiments prove that online RL applications are not only possible but also effective for learning, teaching, executing and improving assembly tasks at the same time. This article paves the way towards the application of online RL algorithms to ASP.
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39.
  • Donati, Benedetta, et al. (författare)
  • Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.
  • 2017
  • Ingår i: Cancer medicine. - : Wiley. - 2045-7634. ; 6:8, s. 1930-1940
  • Tidskriftsartikel (refereegranskat)abstract
    • In an increasing proportion of cases, hepatocellular carcinoma (HCC) develops in patients with nonalcoholic fatty liver disease (NAFLD). Mutations in telomerase reverse transcriptase (hTERT) are associated with familial liver diseases. The aim of this study was to examine telomere length and germline hTERT mutations as associated with NAFLD-HCC. In 40 patients with NAFLD-HCC, 45 with NAFLD-cirrhosis and 64 healthy controls, peripheral blood telomere length was evaluated by qRT-PCR and hTERT coding regions and intron-exon boundaries sequenced. We further analyzed 78 patients affected by primary liver cancer (NAFLD-PLC, 76 with HCC). Enrichment of rare coding mutations (allelic frequency <0.001) was evaluated by Burden test. Functional consequences were estimated in silico and by over-expressing protein variants in HEK-293 cells. We found that telomere length was reduced in individuals with NAFLD-HCC versus those with cirrhosis (P=0.048) and healthy controls (P=0.0006), independently of age and sex. We detected an enrichment of hTERT mutations in NAFLD-HCC, that was confirmed when we further considered a larger cohort of NAFLD-PLC, and was more marked in female patients (P=0.03). No mutations were found in cirrhosis and local controls, and only one in 503 healthy Europeans from the 1000 Genomes Project (allelic frequency=0.025 vs. <0.001; P=0.0005). Mutations with predicted functional impact, including the frameshift Glu113Argfs*79 and missense Glu668Asp, cosegregated with liver disease in two families. Three patients carried missense mutations (Ala67Val in homozygosity, Pro193Leu and His296Pro in heterozygosity) in the N-terminal template-binding domain (P=0.037 for specific enrichment). Besides Glu668Asp, the Ala67Val variant resulted in reduced intracellular protein levels. In conclusion, we detected an association between shorter telomeres in peripheral blood and rare germline hTERT mutations and NAFLD-HCC.
  •  
40.
  • Donnarumma, Francesco, et al. (författare)
  • Learning programs is better than learning dynamics : A programmable neural network hierarchical architecture in a multi-task scenario
  • 2015
  • Ingår i: Adaptive Behavior. - : SAGE Publications. - 1059-7123 .- 1741-2633. ; 24:1, s. 27-51
  • Tidskriftsartikel (refereegranskat)abstract
    • Distributed and hierarchical models of control are nowadays popular in computational modeling and robotics. In the artificial neural network literature, complex behaviors can be produced by composing elementary building blocks or motor primitives, possibly organized in a layered structure. However, it is still unknown how the brain learns and encodes multiple motor primitives, and how it rapidly reassembles, sequences and switches them by exerting cognitive control. In this paper we advance a novel proposal, a hierarchical programmable neural network architecture, based on the notion of programmability and an interpreter-programmer computational scheme. In this approach, complex (and novel) behaviors can be acquired by embedding multiple modules (motor primitives) in a single, multi-purpose neural network. This is supported by recent theories of brain functioning in which skilled behaviors can be generated by combining functional different primitives embedded in “reusable” areas of “recycled” neurons. Such neuronal substrate supports flexible cognitive control, too. Modules are seen as interpreters of behaviors having controlling input parameters, or programs that encode structures of networks to be interpreted. Flexible cognitive control can be exerted by a programmer module feeding the interpreters with appropriate input parameters, without modifying connectivity. Our results in a multiple T -maze robotic scenario show how this computational framework provides a robust, scalable and flexible scheme that can be iterated at different hierarchical layers permitting to learn, encode and control multiple qualitatively different behaviors.
  •  
41.
  • Ghanem, Marc, et al. (författare)
  • Limitations in Evaluating Machine Learning Models for Imbalanced Binary Outcome Classification in Spine Surgery : A Systematic Review
  • 2023
  • Ingår i: Brain Sciences. - : MDPI. - 2076-3425. ; 13:12
  • Forskningsöversikt (refereegranskat)abstract
    • Clinical prediction models for spine surgery applications are on the rise, with an increasing reliance on machine learning (ML) and deep learning (DL). Many of the predicted outcomes are uncommon; therefore, to ensure the models' effectiveness in clinical practice it is crucial to properly evaluate them. This systematic review aims to identify and evaluate current research-based ML and DL models applied for spine surgery, specifically those predicting binary outcomes with a focus on their evaluation metrics. Overall, 60 papers were included, and the findings were reported according to the PRISMA guidelines. A total of 13 papers focused on lengths of stay (LOS), 12 on readmissions, 12 on non-home discharge, 6 on mortality, and 5 on reoperations. The target outcomes exhibited data imbalances ranging from 0.44% to 42.4%. A total of 59 papers reported the model's area under the receiver operating characteristic (AUROC), 28 mentioned accuracies, 33 provided sensitivity, 29 discussed specificity, 28 addressed positive predictive value (PPV), 24 included the negative predictive value (NPV), 25 indicated the Brier score with 10 providing a null model Brier, and 8 detailed the F1 score. Additionally, data visualization varied among the included papers. This review discusses the use of appropriate evaluation schemes in ML and identifies several common errors and potential bias sources in the literature. Embracing these recommendations as the field advances may facilitate the integration of reliable and effective ML models in clinical settings.
  •  
42.
  • Iop, Alessandro, et al. (författare)
  • Extended Reality in Neurosurgical Education : A Systematic Review
  • 2022
  • Ingår i: Sensors. - : MDPI. - 1424-8220. ; 22:16
  • Forskningsöversikt (refereegranskat)abstract
    • Surgical simulation practices have witnessed a rapid expansion as an invaluable approach to resident training in recent years. One emerging way of implementing simulation is the adoption of extended reality (XR) technologies, which enable trainees to hone their skills by allowing interaction with virtual 3D objects placed in either real-world imagery or virtual environments. The goal of the present systematic review is to survey and broach the topic of XR in neurosurgery, with a focus on education. Five databases were investigated, leading to the inclusion of 31 studies after a thorough reviewing process. Focusing on user performance (UP) and user experience (UX), the body of evidence provided by these 31 studies showed that this technology has, in fact, the potential of enhancing neurosurgical education through the use of a wide array of both objective and subjective metrics. Recent research on the topic has so far produced solid results, particularly showing improvements in young residents, compared to other groups and over time. In conclusion, this review not only aids to a better understanding of the use of XR in neurosurgical education, but also highlights the areas where further research is entailed while also providing valuable insight into future applications.
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43.
  • Monetti, Fabio Marco, MSc, 1991-, et al. (författare)
  • An experimental study of the impact of virtual reality training on manufacturing operators on industrial robotic tasks
  • 2022
  • Ingår i: Procedia CIRP. - : Elsevier BV. - 2212-8271. ; , s. 33-38
  • Konferensbidrag (refereegranskat)abstract
    • Despite the recent increase in Virtual Reality (VR) technologies employed for training manufacturing operators on industrial robotic tasks, the impact of VR methods compared to traditional ones is still unclear. This paper presents an experimental comparison of the two training approaches, with novice operators performing the same manufacturing tasks with a VR robot and with a real robot. The hardware selected is an ABB IRB 120 industrial robot, a HTC Vive head mounted display to operate it, besides a corresponding VR model developed in Unity. Twenty-four students performed two actions — drawing and “pick and place” -– in tasks with increasing difficulty, with both the VR model and the real robot. Completion time and task pass rate are adopted to estimate the learning efficiency, while a questionnaire evaluates the users’ satisfaction. The results show that students using VR overall need less elapsed time to complete all tasks, and they record a higher pass rate. The questionnaire answers show that 83% of participants find the VR model helpful in familiarizing with the real robot, and 75% are in favor of using the virtual tool for training novice operators. Users also report that moving the real robot is more complex than the virtual one; adjusting the speed is harder and the possibility of causing damage is worrisome, whereas the VR robot feels safer to operate and easier to drive. The majority of students are satisfied with the design of the tasks, and feel content with the experience. The main finding is that learning from a VR model allows to master driving a real robot quickly and easily. VR training is more useful than conventional methods because it reduces the learning time, allows for training without hindering production, lowers the risk perception, and improves safety for operators and industrial equipment.
  •  
44.
  • Monetti, Fabio Marco, MSc, 1991-, et al. (författare)
  • Industrial transformation and assembly technology: context and research trends
  • 2022
  • Ingår i: Procedia CIRP. - Lugano, Switzerland : Elsevier BV. ; , s. 1427-1432
  • Konferensbidrag (refereegranskat)abstract
    • The fourth industrial revolution is based on a few technological advancements that promise an industrial transformation based on achieving sharing and circular economies. Selecting and applying these advancements correctly, i.e., following relevant value drivers, is a key to the success of manufacturing firms. This results in an increasing body of knowledge from academy and practitioners in the domain of the adoption of digital technology in industry. Given the breadth of the topic, the literature deals with both a vast amount of promising technologies and related existing and prospect industrial application. This work focuses on the contributions in the production sub-domain of assembly systems and technology. In detail, relevant high-impact scientific and engineering works have been identified and analyzed with the purpose of highlighting the innovation patterns in term of the prominent technological advancement (push) and related application (pull). The results of the present study show that the most relevant areas of research are: (1) the Industrial Internet of Things, (2) Augmented and Virtual Reality as assistance to the assembly and applied to the training of operators, and (3) the horizontal and vertical system integration through Digital Twins (DT) and Cyber Physical Systems (CPS). The prominent value drivers are the improvement of resources and processes as well as asset utilization and labor. Moreover, this work represents a first step towards a unitary framework to synchronize different research efforts in the domain of assembly and support the envisaged green industrial transformation.
  •  
45.
  • Monetti, Fabio Marco, MSc, 1991-, et al. (författare)
  • The Impact of Learning Factories on Teaching Lean Principles in an Assembly Environment
  • 2022
  • Ingår i: Proceedings of FAIM 2022. - Detroit, MI : Springer Nature. ; , s. 271-283
  • Konferensbidrag (refereegranskat)abstract
    • Learning factories are realistic manufacturing environments built for education; many universities have recently introduced learning factories in engineering programs to tackle real industrial problems; however, statistical studies on its effectiveness are still scarce. This paper presents a statistical study on the impact of learning factories on the students’ learning process, when teaching the lean manufacturing concepts in an assembly environment. The analysis is carried out through the Lean Manufacturing Lab at KTH, a learning factory supporting the traditional educational activities. In the lab, the students assemble a product on an assembly line; during three rounds, they identify problems on the line, apply the appropriate lean tools to overcome the problems, and try to achieve a higher productivity. The study is based on the analysis of the times recorded during the sessions of the lab. A questionnaire submitted to the students after the course evaluates the level of knowledge of lean production principles that the students achieved. The results are twofold: the improvement of the assembly times through the implementation of the lean tools and the positive effect of a hands-on experience on the students’ understanding of the lean principles, highlighted by the answers to the questionnaire. The main contributions are that applying the lean tools on an assembly line improves the productivity even with inexperienced operators, implementing a learning factory is effective in enhancing the learning process, and, lastly, that a first-hand experience applying the lean tools in a real assembly environment is an added value to the students’ education.
  •  
46.
  • Polistena, Andrea, et al. (författare)
  • MMP7 Expression in Colorectal Tumours of Different Stages
  • 2014
  • Ingår i: In Vivo. - 0258-851X. ; 28:1, s. 105-110
  • Tidskriftsartikel (refereegranskat)abstract
    • Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Methods: 28 patients surgically-treated for benign and malignant colorectal tumours were recruited and analyzed for MMP7 in tumoural tissue, lymph nodes and serum by histology, immunohistochemistry, ELISA and western blotting. Results: Immunohistochemistu showed prevalent expression of MMP7 in advanced cancer. A significant increase (p < 0.001) was evident in serum of stage III/IV cancers compared to both adenomas and non-metastatic disease. MMP7 was increased in cancer tissues with prevalence in stage I/II. Lymph nodes presented a significant increase of MMP7 (p < 0.05 adenoma vs. stage I/II and p < 0.001 vs. stage III/IV). Conclusion: MMP7 increases with dysplasia and cancer disease stage in tumour tissue as well as in the regional lymph nodes. It may be used as a complement in investigating suspected locally advanced cancer.
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