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| 2. |
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| 3. |
- Abdellaoui, G., et al.
(author)
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Meteor studies in the framework of the JEM-EUSO program
- 2017
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In: Planetary and Space Science. - : Elsevier. - 0032-0633 .- 1873-5088. ; 143, s. 245-255
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Journal article (peer-reviewed)abstract
- We summarize the state of the art of a program of UV observations from space of meteor phenomena, a secondary objective of the JEM-EUSO international collaboration. Our preliminary analysis indicates that JEM-EUSO, taking advantage of its large FOV and good sensitivity, should be able to detect meteors down to absolute magnitude close to 7. This means that JEM-EUSO should be able to record a statistically significant flux of meteors, including both sporadic ones, and events produced by different meteor streams. Being unaffected by adverse weather conditions, JEM-EUSO can also be a very important facility for the detection of bright meteors and fireballs, as these events can be detected even in conditions of very high sky background. In the case of bright events, moreover, exhibiting some persistence of the meteor train, preliminary simulations show that it should be possible to exploit the motion of the ISS itself and derive at least a rough 3D reconstruction of the meteor trajectory. Moreover, the observing strategy developed to detect meteors may also be applied to the detection of nuclearites, exotic particles whose existence has been suggested by some theoretical investigations. Nuclearites are expected to move at higher velocities than meteoroids, and to exhibit a wider range of possible trajectories, including particles moving upward after crossing the Earth. Some pilot studies, including the approved Mini-EUSO mission, a precursor of JEM-EUSO, are currently operational or in preparation. We are doing simulations to assess the performance of Mini-EUSO for meteor studies, while a few meteor events have been already detected using the ground-based facility EUSO-TA.
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| 4. |
- Elhai, M, et al.
(author)
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Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study
- 2019
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In: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 78:7, s. 979-987
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Journal article (peer-reviewed)abstract
- To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.MethodsWe performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab.Results254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47–5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55–1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56–3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83–9.62]; p=0.019 as compared with controls vs 3 [0.66–5.35]; p=0.012).ConclusionRituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.
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| 5. |
- Abdellaoui, G., et al.
(author)
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First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere
- 2018
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In: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 13
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Journal article (peer-reviewed)abstract
- EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25(th) of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector.
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| 6. |
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| 7. |
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| 8. |
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| 9. |
- Amelino-Camelia, G., et al.
(author)
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Physics with the KLOE-2 experiment at the upgraded DA Phi NE
- 2010
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 68:3-4, s. 619-681
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Research review (peer-reviewed)abstract
- Investigation at a f-factory can shed light on several debated issues in particle physics. We discuss: (i) recent theoretical development and experimental progress in kaon physics relevant for the Standard Model tests in the flavor sector, (ii) the sensitivity we can reach in probing CPT and Quantum Mechanics from time evolution of entangled-kaon states, (iii) the interest for improving on the present measurements of non-leptonic and radiative decays of kaons and eta/eta' mesons, (iv) the contribution to understand the nature of light scalar mesons, and (v) the opportunity to search for narrow di-lepton resonances suggested by recent models proposing a hidden dark-matter sector. We also report on the e(+)e(-) physics in the continuum with the measurements of (multi) hadronic cross sections and the study of gamma gamma processes.
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| 10. |
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| 11. |
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| 12. |
- Babusci, D., et al.
(author)
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Precision measurement of sigma (e(+)e(-) -> pi(+)pi(-)gamma)/sigma(e(+)e(-) ->mu(+)mu(-)gamma) and determination of the pi(+)pi(-) contribution to the muon anomaly with the KLOE detector
- 2013
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 720:4-5, s. 336-343
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Journal article (peer-reviewed)abstract
- We have measured the ratio cr (e(+)e(-) -> pi(+)pi(-)gamma)/sigma(e(+)e(-) -> mu(+)mu(-)gamma), with the KLOE detector at DA Phi NE for a total integrated luminosity of similar to 240 pb(-1). From this ratio we obtain the cross section sigma (e(+)e(-) -> pi(+)pi(-)gamma). From the cross section we determine the pion form factor vertical bar F-pi vertical bar(2) and the two-pion contribution to the muon anomaly a(mu) for 0.592< M-pi pi < 0.975 GeV, Delta(pi pi) a(mu) = (385.1 +/- 1.1(stat) +/- 2.7(sys+theo)) x 10(-10). This result confirms the current discrepancy between the Standard Model calculation and the experimental measurement of the muon anomaly. (c) 2013 Elsevier B.V. All rights reserved.
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| 13. |
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| 14. |
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| 15. |
- Horwich, A, et al.
(author)
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EAU–ESMO consensus statements on the management of advanced and variant bladder cancer - an international collaborative multi-stakeholder effort : under the auspices of the EAU and ESMO Guidelines Committees
- 2019
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In: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 30:11, s. 1697-1727
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Journal article (peer-reviewed)abstract
- BACKGROUND: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial.OBJECTIVE: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management.DESIGN: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts before voting during a consensus conference.SETTING: Online Delphi survey and consensus conference.PARTICIPANTS: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus).RESULTS AND LIMITATIONS: Overall, 116 statements were included in the Delphi survey. Of these, 33 (28%) statements achieved level 1 consensus and 49 (42%) statements achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease and the evolving role of checkpoint inhibitor therapy in metastatic disease.CONCLUSIONS: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time where further evidence is available to guide our approach.
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| 16. |
- Babusci, D., et al.
(author)
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A new limit on the CP violating decay K-S -> 3 pi(0) with the KLOE experiment
- 2013
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 723:1-3, s. 54-60
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Journal article (peer-reviewed)abstract
- We have carried out a new direct search for the CP violating decay K-S -> 3 pi(0) with 1.7 fb(-1) of e(+)e(-) collisions collected by the KLOE detector at the Phi-factory DA Phi NE. We have searched for this decay in a sample of about 5.9 x 10(8) KSKL events tagging the K-S by means of the K-L interaction in the calorimeter and requiring six prompt photons. With respect to our previous search, the analysis has been improved by increasing of a factor four the tagged sample and by a more effective background rejection of fake K-S tags and spurious clusters. We find no candidates in data and simulated background samples, while we expect 0.12 standard model events. Normalizing to the number of K-S -> 2 pi(0) events in the same sample, we set the upper limit on BR(K-S -> 3 pi(0)) <= 2.6 x 10(-8) at 90% C.L., five times lower than the previous limit. We also set the upper limit on the eta(000) parameter, vertical bar eta(000)vertical bar <= 0.0088 at 90% C.L., improving by a factor two the latest direct measurement. (c) 2013 Elsevier B.V. All rights reserved.
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| 17. |
- Babusci, D., et al.
(author)
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Measurement of Γ(η→π+π-γ)/Γ(η→π+π-π0) with the KLOE detector
- 2013
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 718:3, s. 910-914
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Journal article (peer-reviewed)abstract
- The ratio Rη=Γ(η→π+π-γ)/Γ(η→π+π-π0) has been measured by analysing 22 million φ→ηγ decays collected by the KLOE experiment at DAΦNE, corresponding to an integrated luminosity of 558 pb-1. The η→π+π-γ proceeds both via the ρ resonant contribution, and possibly a non-resonant direct term, connected to the box anomaly. Our result, Rη=0.1856±0.0005stat±0.0028syst, points out a sizable contribution of the direct term to the total width. The di-pion invariant mass for the η→π+π-γ decay could be described in a model-independent approach in terms of a single free parameter, α. The determined value of the parameter α is α=(1.32±0.08stat-0.09syst+0.10±0.02theo) GeV-2.
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| 18. |
- Beyer, J., et al.
(author)
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Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer
- 2013
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In: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 24:4, s. 878-888
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Research review (peer-reviewed)abstract
- In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part II. Eur Urol 2008; 53: 497-513]. A panel of 56 of 60 invited GCC experts from all across Europe discussed all aspects on diagnosis and treatment of GCC, with a particular focus on acute and late toxic effects as well as on survivorship issues. The panel consisted of oncologists, urologic surgeons, radiooncologists, pathologists and basic scientists, who are all actively involved in care of GCC patients. Panelists were chosen based on the publication activity in recent years. Before the meeting, panelists were asked to review the literature published since 2006 in 20 major areas concerning all aspects of diagnosis, treatment and follow-up of GCC patients, and to prepare an updated version of the previous recommendations to be discussed at the conference. In addition, similar to 50 E-vote questions were drafted and presented at the conference to address the most controversial areas for a poll of expert opinions. Here, we present the main recommendations and controversies of this meeting. The votes of the panelists are added as online supplements.
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| 19. |
- Martucci, M., et al.
(author)
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Analysis on H spectral shape during the early 2012 SEPs with the PAMELA experiment
- 2014
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 742, s. 158-161
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Journal article (peer-reviewed)abstract
- The satellite-borne PAMELA experiment has been continuously collecting data since 2006. This apparatus is designed to study charged particles in the cosmic radiation. The combination of a permanent magnet, a silicon strip tracker and a silicon-tungsten imaging calorimeter, and the redundancy of instrumentation allow very precise studies on the physics of cosmic rays in a wide energy range and with high statistics. This makes PAMELA a very suitable instrument for Solar Energetic Particle (SEP) observations. Not only does it span the energy range between the ground-based neutron monitor data and the observations of SEPs from space, but PAMELA also carries out the first direct measurements of the composition for the highest energy SEP events, including those causing Ground Level Enhancements (GLEs). In particular, PAMELA has registered many SEP events during solar cycle 24, offering unique opportunities to address the question of high-energy SEP origin. A preliminary analysis on proton spectra behaviour during this event is presented in this work.
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| 20. |
- Adriani, O., et al.
(author)
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Cosmic-Ray Positron Energy Spectrum Measured by PAMELA
- 2013
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 111:8, s. 081102-
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Journal article (peer-reviewed)abstract
- Precision measurements of the positron component in the cosmic radiation provide important information about the propagation of cosmic rays and the nature of particle sources in our Galaxy. The satellite-borne experiment PAMELA has been used to make a new measurement of the cosmic-ray positron flux and fraction that extends previously published measurements up to 300 GeV in kinetic energy. The combined measurements of the cosmic-ray positron energy spectrum and fraction provide a unique tool to constrain interpretation models. During the recent solar minimum activity period from July 2006 to December 2009, approximately 24 500 positrons were observed. The results cannot be easily reconciled with purely secondary production, and additional sources of either astrophysical or exotic origin may be required.
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| 21. |
- Archilli, F., et al.
(author)
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Search for a vector gauge boson in phi meson decays with the KLOE detector KLOE-2 Collaboration
- 2012
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 706:4-5, s. 251-255
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Journal article (peer-reviewed)abstract
- The existence of a light dark force mediator has been tested with the KLOE detector at DA Phi NE. This particle, called U. is searched for using the decay chain phi -> eta U, eta -> pi(+)pi(-)pi(0), U -> e(+)e(-). No evidence is found in 1.5 fb(-1) of data. The resulting exclusion plot covers the mass range 5 < M-U < 470 MeV, setting an upper limit on the ratio between the U boson coupling constant and the One structure constant, alpha'/alpha, of <= 2 x 10(-5) at 90% C.L. for 50 < M-U < 420 MeV.
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| 22. |
- Babusci, D., et al.
(author)
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Limit on the production of a light vector gauge boson in phi meson decays with the KLOE detector
- 2013
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 720:1-3, s. 111-115
-
Journal article (peer-reviewed)abstract
- We present a new limit on the production of a light dark-force mediator with the KLOE detector at DA Phi NE. This boson, called U, has been searched for in the decay phi -> eta U, U -> e(+)e(-), analyzing the. decay eta -> pi(0)pi(0)pi(0) in a data sample of 1.7 fb(-1). No structures are observed in the e(+)e(-) invariant mass distribution over the background. This search is combined with a previous result obtained from the decay eta -> pi(+)pi(-)pi(0), increasing the sensitivity. We set an upper limit at 90% C.L. on the ratio between the U boson coupling constant and the fine structure constant of alpha'/alpha < 1.7 x 10(-5) for 30 < M-U < 400 MeV and alpha'/alpha <= 8 x 10(-6) for the sub-region 50 < M-U <210 MeV. This result assumes the Vector Meson Dominance expectations for the phi eta gamma* transition form factor. The dependence of this limit on the transition form factor has also been studied.
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| 23. |
- Babusci, D., et al.
(author)
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Measurement of eta meson production in gamma gamma interactions and Gamma(eta -> gamma gamma) with the KLOE detector
- 2013
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In: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :1, s. 119-
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Journal article (peer-reviewed)abstract
- We present a measurement of eta meson production in photon-photon interactions produced by electron-positron beams colliding with root s = 1 GeV. The measurement is done with the KLOE detector at the phi-factory DA Phi NE with an integrated luminosity of 0.24 fb(-1). The e(+)e(-) -> e(+)e(-)eta cross section is measured without detecting the outgoing electron and positron, selecting the decays eta -> pi(+)pi(-)pi(0) and eta -> pi(0)pi(0)pi(0). The most relevant background is due to e(+)e(-) -> eta gamma when the monochromatic photon escapes detection. The cross section for this process is measured as sigma(e(+)e(-) -> eta gamma) = (856 +/- 8(stat) +/- 16(syst)) pb. The combined result for the e(+)e(-) -> e(+)e(-)eta cross section is sigma(e(+)e(-) -> e(+)e(-)eta) = (32.72 +/- 1.27(stat) +/- 0.70(syst)) pb. From this we derive the partial width Gamma(eta -> gamma gamma) = (520 +/- 20(stat) +/- 13(syst)) eV. This is in agreement with the world average and is the most precise measurement to date.
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| 24. |
- Babusci, D., et al.
(author)
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Test of CPT and Lorentz symmetry in entangled neutral kaons with the KLOE experiment
- 2014
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 730, s. 89-94
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Journal article (peer-reviewed)abstract
- Neutral kaon pairs produced in phi decays in anti-symmetric entangled state can be exploited to search for violation of CPT symmetry and Lorentz invariance. We present an analysis of the CP-violating process phi -> KSKL -> pi(+)pi(-)pi(+)pi(-) based on 1.7 fb(-1) of data collected by the KLOE experiment at the Frascati phi-factory DA Phi NE. The data are used to perform a Measurement of the CPT-violating parameters Delta a(mu) for neutral kaons in the context of the Standard Model Extension framework. The parameters measured in the reference frame of the fixed stars are: Delta a(0) = (-6.0 +/- 7.7(stat)+/- 3.1(syst)) X 10(-18) GeV, Delta a(x) = (0.9 +/- 1.5(stat)+/- 0.6(syst)) X 10(-18) GeV, Delta a(y) = (-2.0 +/- 1.5(stat)+/- 0.5(syst)) X 10(-18) GeV, Delta a(z) = (3.1 +/- 1.7(stat)+/- 0.5(syst)) X 10(-18) GeV. These are presently the most precise measurements in the quark sector of the Standard Model Extension. (C) 2014 The Authors. Published by Elsevier B.V.
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| 25. |
- Boezio, M., et al.
(author)
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The PAMELA experiment and antimatter in the universe
- 2014
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In: Hyperfine Interactions. - : Springer Science and Business Media LLC. - 0304-3843 .- 1572-9540. ; 228:1-3, s. 101-109
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Journal article (peer-reviewed)abstract
- On the 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The primary scientific goal is the measurement of the antiproton and positron energy spectra. Antiparticles are a natural component of the cosmic radiation being produced in the interaction between cosmic rays and the interstellar matter. They have been shown to be extremely interesting for understanding the propagation mechanisms of cosmic rays. Furthermore, novel sources of primary cosmic-ray antiparticles of either astrophysical or exotic origin (e.g. annihilation of dark matter particles) can also be probed. In this paper we review the PAMELA antiparticle results and their significance for the field of astroparticle physics.
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| 26. |
- Bruno, A., et al.
(author)
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Geomagnetically trapped, albedo and solar energetic particles : Trajectory analysis and flux reconstruction with PAMELA
- 2017
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In: Advances in Space Research. - : Elsevier. - 0273-1177 .- 1879-1948. ; 60:4, s. 788-795
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Journal article (peer-reviewed)abstract
- The PAMELA satellite experiment is providing comprehensive observations of the interplanetary and magnetospheric radiation in the near-Earth environment. Thanks to its identification capabilities and the semi-polar orbit, PAMELA is able to precisely measure the energetic spectra and the angular distributions of the different cosmic-ray populations over a wide latitude region, including geomagnetically trapped and albedo particles. Its observations comprise the solar energetic particle events between solar cycles 23 and 24, and the geomagnetic cutoff variations during magnetospheric storms. PAMELA's measurements are supported by an accurate analysis of particle trajectories in the Earth's magnetosphere based on a realistic geomagnetic field modeling, which allows the classification of particle populations of different origin and the investigation of the asymptotic directions of arrival.
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| 27. |
- Bruno, A., et al.
(author)
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Solar energetic particle events : Trajectory analysis and flux reconstruction with PAMELA
- 2015
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In: Proceedings of Science. - : Proceedings of science.
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Conference paper (peer-reviewed)abstract
- The PAMELA satellite experiment is providing first direct measurements of Solar Energetic Particles (SEPs) with energies from about 80 MeV to several GeV in near-Earth space, bridging the low energy data by other space-based instruments and the Ground Level Enhancement (GLE) data by the worldwide network of neutron monitors. Its unique observational capabilities include the possibility of measuring the flux angular distribution and thus investigating possible anisotropies. This work reports the analysis methods developed to estimate the SEP energy spectra as a function of the particle pitch-angle with respect to the Interplanetary Magnetic Field (IMF) direction. The crucial ingredient is provided by an accurate simulation of the asymptotic exposition of the PAMELA apparatus, based on a realistic reconstruction of particle trajectories in the Earth's magnetosphere. As case study, the results for the May 17, 2012 event are presented.
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| 28. |
- Formato, V., et al.
(author)
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Measurement of hydrogen and helium isotopes flux in galactic cosmic rays with the PAMELA experiment
- 2014
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 742, s. 273-275
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Journal article (peer-reviewed)abstract
- PAMELA is a satellite borne experiment designed to study with great accuracy cosmic rays of galactic, solar, and trapped nature, with particular focus on the antimatter component. The detector consists of a permanent magnet spectrometer core to provide rigidity and charge sign information, a Time-of-Flight system for velocity and charge information, a Silicon-Tungsten calorimeter and a Neutron detector for lepton/hadron identification. The velocity and rigidity information allow the identification of different isotopes for Z = 1 and Z = 2 particles in the energy range 100 MeV/n to 1 GeV/n. In this work we will present the PAMELA results on the H and He isotope fluxes based on the data collected during the 23rd solar minimum from 2006 to 2007. Such fluxes carry relevant information helpful in constraining parameters in galactic cosmic rays propagation models complementary to those obtained from other secondary to primary measurements such as the boron-to-carbon ratio.
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| 29. |
- Ricciarini, S. B., et al.
(author)
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PAMELA mission : Heralding a new era in cosmic ray physics
- 2014
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In: EPJ Web of Conferences. - : EDP Sciences. - 2100-014X.
-
Conference paper (peer-reviewed)abstract
- After seven years of data taking in space, the experiment PAMELA is showing very interesting features in cosmic rays, namely in the fluxes of protons, helium, electrons, that might change our basic vision of the mechanisms of production, acceleration and propagation of cosmic rays in the galaxy. In addition, PAMELA measurements of cosmic antiproton and positron fluxes are setting strong constraints to the nature of Dark Matter. The continuous particle detection is allowing a constant monitoring of the solar activity and detailed study of the solar modulation for a long period, giving important improvements to the comprehension of the heliosphere mechanisms. PAMELA is also measuring the radiation environment around the Earth, and has recently discovered an antiproton radiation belt.
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| 30. |
- Adriani, O., et al.
(author)
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Measurement of Boron and Carbon Fluxes in Cosmic Rays with the Pamela Experiment
- 2014
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In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 791:2, s. 93-
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Journal article (peer-reviewed)abstract
- The propagation of cosmic rays inside our galaxy plays a fundamental role in shaping their injection spectra into those observed at Earth. One of the best tools to investigate this issue is the ratio of fluxes for secondary and primary species. The boron-to-carbon (B/C) ratio, in particular, is a sensitive probe to investigate propagation mechanisms. This paper presents new measurements of the absolute fluxes of boron and carbon nuclei as well as the B/C ratio from the PAMELA space experiment. The results span the range 0.44-129 GeV/n in kinetic energy for data taken in the period 2006 July to 2008 March.
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| 31. |
- Adriani, O., et al.
(author)
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Pamela's measurements of magnetospheric effects on high-energy solar particles
- 2015
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In: Astrophysical Journal Letters. - 2041-8205 .- 2041-8213. ; 801:1
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Journal article (peer-reviewed)abstract
- The nature of particle acceleration at the Sun, whether through flare reconnection processes or through shocks driven by coronal mass ejections, is still under scrutiny despite decades of research. The measured properties of solar energetic particles (SEPs) have long been modeled in different particle-acceleration scenarios. The challenge has been to disentangle the effects of transport from those of acceleration. The Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) instrument enables unique observations of SEPs including the composition and angular distribution of the particles about the magnetic field, i.e., pitch angle distribution, over a broad energy range (>80 MeV)-bridging a critical gap between space-based and ground-based measurements. We present high-energy SEP data from PAMELA acquired during the 2012 May 17 SEP event. These data exhibit differential anisotropies and thus transport features over the instrument rigidity range. SEP protons exhibit two distinct pitch angle distributions: a low-energy population that extends to 90 degrees and a population that is beamed at high energies (>1 GeV), consistent with neutron monitor measurements. To explain a low-energy SEP population that exhibits significant scattering or redistribution accompanied by a high-energy population that reaches the Earth relatively unaffected by dispersive transport effects, we postulate that the scattering or redistribution takes place locally. We believe that these are the first comprehensive measurements of the effects of solar energetic particle transport in the Earth's magnetosheath.
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| 32. |
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| 33. |
- Karelin, A. V., et al.
(author)
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North-south asymmetry for high-energy cosmic-ray electrons measured with the PAMELA experiment
- 2013
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In: Journal of Experimental and Theoretical Physics. - 1063-7761 .- 1090-6509. ; 117:2, s. 268-273
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Journal article (peer-reviewed)abstract
- The north-south asymmetry for cosmic-ray particles was measured with one instrument of the PAMELA satellite-borne experiment in the period June 2006-May 2009. The analysis has been performed by two independent methods: by comparing the count rates in regions with identical geomagnetic conditions and by comparing the experimental distribution of particle directions with the simulated distribution that would be in the case of an isotropic particle flux. The dependences of the asymmetry on energy release in the PAMELA calorimeter and on time have been constructed. The asymmetry (N (n) - N (s) )/(N (n) + N (s) ) is 0.06 +/- 0.004 at the threshold energy release in the calorimeter and gradually decreases with increasing energy release. The observed effect is shown to be produced by electrons in the energy range 10-100 GeV.
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| 34. |
- Koldobskiy, S. A., et al.
(author)
-
Deuteron spectrum measurements under radiation belt with PAMELA instrument
- 2016
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In: Nuclear and Particle Physics Proceedings. - : Elsevier. - 2405-6014. ; 273-275, s. 2345-2347
-
Journal article (peer-reviewed)abstract
- In this work the results of data analysis of the deuteron albedo radiation obtained in the PAMELA experiment are presented. PAMELA is an international space experiment carried out on board of the satellite Resurs DK-1. The high precision detectors allow to register and identify cosmic ray particles in a wide energy range. The albedo deuteron spectrum in the energy range 70 - 600 MeV/nucleon has been measured.
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| 35. |
- Koldobskiy, S., et al.
(author)
-
Measuring the albedo deuteron flux in the PAMELA satellite experiment
- 2015
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In: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738. ; 79:3, s. 294-297
-
Journal article (peer-reviewed)abstract
- The results of measuring albedo deuteron fluxes in the vicinity of the Earth are presented. The data were obtained in the PAMELA experiment conducted aboard the Resurs DK-1 artificial Earth satellite. High-precision detectors of the instrument setup allow us to identify albedo deuterons and measure their spectra in the energy interval from 70 to 600 MeV/nucleon at altitudes of 350–600 km for different geomagnetic latitudes.
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| 36. |
- Martucci, M., et al.
(author)
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Magnetospheric effects on high-energy solar particles during the 2012 May 17th event measured with the PAMELA experiment
- 2015
-
In: Proceedings of Science. - : Proceedings of Science (PoS).
-
Conference paper (peer-reviewed)abstract
- The great challenge in constraining scenarios for solar energetic particle (SEP) acceleration is due to the fact that the signatures of acceleration itself are heavily modified by transport within interplanetary space. During transport, SEPs are subject to pitch angle scattering by the turbulent magnetic field, adiabatic focusing, or reflecting magnetic structures. Ground Level Enhancements (GLEs) provide an ideal way to study acceleration with minimal transport. In this work, we present a unique high-energy SEP observation from PAMELA of the 2012 May 17 GLE and interpret the observed pitch angle distributions as a result of local scattering (1 AU) by the Earth's magnetosheath.
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| 37. |
- Menn, W., et al.
(author)
-
The PAMELA space experiment
- 2013
-
In: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 209-218
-
Journal article (peer-reviewed)abstract
- On the 15th of June 2006, the PAMELA satellite-borne experiment was launched from the Baikonur cosmodrome and it has been collecting data since July 2006. The apparatus is comprised of a time-of-flight system, a silicon-microstrip magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail counter scintillator and a neutron detector. The combination of these devices allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV to 100's GeV) with high statistics. The primary scientific goal is the measurement of the antiproton and positron energy spectra in order to search for exotic sources, such as dark matter particle annihilations. PAMELA is also searching for primordial antinuclei (anti-helium), and testing cosmic-ray propagation models through precise measurements of the antiparticle energy spectrum and precision studies of light nuclei and their isotopes. Moreover, PAMELA is investigating phenomena connected with solar and earth physics. After 4 years of operation in flight, PAMELA is now delivering coherent results about spectra and chemical composition of the charged cosmic radiation, allowing scenarios of production and propagation of cosmic rays to be fully established and understood.
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| 38. |
- Mikhailov, V. V., et al.
(author)
-
Anisotropy analysis of positron data with the PAMELA experiment
- 2013
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In: Proceedings of the 33rd International Cosmic Rays Conference, ICRC 2013. - : Sociedade Brasileira de Fisica. - 9788589064293
-
Conference paper (peer-reviewed)abstract
- The PAMELA experiment is carried out on board of satellite the Resurs DK1 since 2006 for precision study of cosmic ray antiparticles. The instrument is equipped with magnetic spectrometer, silicon-tungsten imaging electromagnetic calorimeter, neutron detector which give possibility to separate electron and positron over wide energy range up to hundreds GeVs and to measure their incoming direction with accuracy about 2 degree. For each detected particle a space arriving direction was reconstructed using trajectory inside the instrument and the satellite position on the orbit. Backtracking in geomagnetic field was done to obtain initial spatial distribution of particles outside of the Earth magnetosphere. This paper discuss a result of search a possible local sources by anisotropy analysis of positron data.
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| 39. |
- Mikhailov, V. V., et al.
(author)
-
Method of electrons and positrons separations by bremsstrahlung in the PAMELA experiment
- 2013
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In: Proceedings of the 33rd International Cosmic Rays Conference, ICRC 2013. - : Sociedade Brasileira de Fisica. - 9788589064293
-
Conference paper (peer-reviewed)abstract
- Imaging calorimeter of the PAMELA instrument on board the Resurs DK satellite has high spatial resolution and allows to measure separately electromagnetic showers from electrons and positrons and their bremsstahlung produced in ToF detectors of the instrument. Measuring events with two showers provides proton rejection coefficient more than 104 at energy between 0.5 and 3 GeV. Results of positrons fractions obtained by this method are in agreement with previously published data of the PAMELA experiment at low energy. It confirms in independent way strong positron modulation during period of negative polarity of the Sun magnetic field.
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| 40. |
- Munini, R., et al.
(author)
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Short-term variation in the galactic cosmic ray intensity measured with the PAMELA experiment
- 2017
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In: Proceedings of Science. - : Sissa Medialab Srl.
-
Conference paper (peer-reviewed)abstract
- New results on the galactic cosmic ray (GCR) short-term intensity variation associated with Forbush decrease and co-rotating interaction regions (CIRs) measured by the PAMELA instrument between November 2006 and March 2007 are presented. Most of the past measurements on Forbush decrease events were carried out with neutron monitor detector. This tecnique allows only indirect detection of the overall GCR intensity over an integrated energy range. For the first time, thanks to the unique features of the PAMELA magnetic spectrometer, the Forbush decrease associated with the December 13th coronal mass ejection (CME) was studied in a wide rigidity range (0.4 - 20 GV) and for different species of GCRs detected directly in space. Using GCR protons, the amplitude and the recovery time of the Forbush decrease were studied for ten rigidity interval with a temporal resolution of one day. For comparison the helium and the electron intensity over time were also studied. The temporal evolution of the helium and proton intensity was found in good agreement while the electrons show, on average, a faster recovery time. This was interpreted as a charge-sign dependence introduced by drift motion experienced by the low rigidity (< 5 GV) GCRs during their propagation through the heliosphere. Moreover a clear 13.5 days cyclical variation was observed in the GCR proton intensity after the Forbush decrease. This phenomena could be interpreted as an effect of prominent structures of compressed plasma in the solar wind, i.e. CIRs, or to the latitudinal gradient due to the crossing of the heliospheric current sheet (HCS).
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| 41. |
- Usoskin, I. G., et al.
(author)
-
Force-field parameterization of the galactic cosmic ray spectrum : Validation for Forbush decreases
- 2015
-
In: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 55:12, s. 2940-2945
-
Journal article (peer-reviewed)abstract
- A useful parametrization of the energy spectrum of galactic cosmic rays (GCR) near Earth is offered by the so-called force-field model which describes the shape of the entire spectrum with a single parameter, the modulation potential. While the usefulness of the force-field approximation has been confirmed for regular periods of solar modulation, it was not tested explicitly for disturbed periods, when GCR are locally modulated by strong interplanetary transients. Here we use direct measurements of protons and alpha-particles performed by the PAMELA space-borne instrument during December 2006, including a major Forbush decrease, in order to directly test the validity of the force-field parameterization. We conclude that (1) The force-field parametrization works very well in describing the energy spectra of protons and alpha-particles directly measured by PAMELA outside the Earths atmosphere; (2) The energy spectrum of GCR can be well parameterized by the force-field model also during a strong Forbush decrease; (3) The estimate of the GCR modulation parameter, obtained using data from the world-wide neutron monitor network, is in good agreement with the spectra directly measured by PAMELA during the studied interval. This result is obtained on the basis of a single event analysis, more events need to be analyzed.
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| 42. |
- Witjes, J. Alfred, et al.
(author)
-
EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer – An International Collaborative Multistakeholder Effort : Under the Auspices of the EAU-ESMO Guidelines Committees
- 2020
-
In: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 77:2, s. 223-250
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial.OBJECTIVE: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management.DESIGN: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts prior to voting during a consensus conference.SETTING: Online Delphi survey and consensus conference.PARTICIPANTS: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), and 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus).RESULTS AND LIMITATIONS: Overall, 116 statements were included in the Delphi survey. Of these statements, 33 (28%) achieved level 1 consensus and 49 (42%) achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease, and the evolving role of checkpoint inhibitor therapy in metastatic disease.CONCLUSIONS: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time when further evidence is available to guide our approach.PATIENT SUMMARY: This report summarises findings from an international, multistakeholder project organised by the EAU and ESMO. In this project, a steering committee identified areas of bladder cancer management where there is currently no good-quality evidence to guide treatment decisions. From this, they developed a series of proposed statements, 71 of which achieved consensus by a large group of experts in the field of bladder cancer. It is anticipated that these statements will provide further guidance to health care professionals and could help improve patient outcomes until a time when good-quality evidence is available.
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| 43. |
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| 44. |
- Adriani, O., et al.
(author)
-
Cosmic-Ray Electron Flux Measured by the PAMELA Experiment between 1 and 625 GeV
- 2011
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 106:20, s. 201101-
-
Journal article (peer-reviewed)abstract
- Precision measurements of the electron component in the cosmic radiation provide important information about the origin and propagation of cosmic rays in the Galaxy. Here we present new results regarding negatively charged electrons between 1 and 625 GeV performed by the satellite-borne experiment PAMELA. This is the first time that cosmic-ray e(-) have been identified above 50 GeV. The electron spectrum can be described with a single power-law energy dependence with spectral index -3.18 +/- 0.05 above the energy region influenced by the solar wind (> 30 GeV). No significant spectral features are observed and the data can be interpreted in terms of conventional diffusive propagation models. However, the data are also consistent with models including new cosmic-ray sources that could explain the rise in the positron fraction.
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| 45. |
- Adriani, O., et al.
(author)
-
Measurement of the flux of primary cosmic ray antiprotons with energies of 60 MeV to 350 GeV in the PAMELA experiment
- 2013
-
In: JETP Letters. - 0021-3640 .- 1090-6487. ; 96:10, s. 621-627
-
Journal article (peer-reviewed)abstract
- It is interesting to measure the antiproton galactic component in cosmic rays in order to study the mechanisms by which particles and antiparticles are generated and propagate in the Galaxy and to search for new sources of, e.g., annihilation or decay of dark matter hypothetical particles. The antiproton spectrum and the ratio of the fluxes of primary cosmic ray antiprotons to protons with energies of 60 MeV to 350 GeV found from the data obtained from June 2006 to January 2010 in the PAMELA experiment are presented. The usage of the advanced data processing method based on the data classification mathematical model made it possible to increase statistics and analyze the region of higher energies than in the earlier works.
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| 46. |
- Adriani, O., et al.
(author)
-
Measurement of the isotopic composition of hydrogen and helium nuclei in cosmic rays with the PAMELA experiment
- 2013
-
In: Astrophysical Journal. - : IOP Publishing. - 0004-637X .- 1538-4357. ; 770:1, s. 2-
-
Journal article (peer-reviewed)abstract
- The satellite-borne experiment PAMELA has been used to make new measurements of cosmic ray H and He isotopes. The isotopic composition was measured between 100 and 600 MeV /n for hydrogen and between 100 and 900 MeV /n for helium isotopes over the 23rd solar minimum from 2006 July to 2007 December. The energy spectrum of these components carries fundamental information regarding the propagation of cosmic rays in the galaxy which are competitive with those obtained from other secondary to primary measurements such as B/C.
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| 47. |
- Adriani, O., et al.
(author)
-
MEASUREMENTS OF COSMIC-RAY HYDROGEN AND HELIUM ISOTOPES WITH THE PAMELA EXPERIMENT
- 2016
-
In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 818:1
-
Journal article (peer-reviewed)abstract
- The cosmic-ray hydrogen and helium (H-1, H-2, He-3, He-4) isotopic composition has been measured with the satellite-borne experiment PAMELA, which was launched into low-Earth orbit on board the Resurs-DK1 satellite on 2006 June 15. The rare isotopes H-2 and He-3 in cosmic rays are believed to originate mainly from the interaction of high-energy protons and helium with the galactic interstellar medium. The isotopic composition was measured between 100 and 1100 MeV/n for hydrogen and between 100 and 1400 MeV/n for helium isotopes using two different detector systems over the 23rd solar minimum from 2006 July to 2007 December.
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| 48. |
- Adriani, O., et al.
(author)
-
Measurements of cosmic-ray proton and helium spectra with the PAMELA calorimeter
- 2013
-
In: Advances in Space Research. - : Elsevier BV. - 0273-1177 .- 1879-1948. ; 51:2, s. 219-226
-
Journal article (peer-reviewed)abstract
- We present a new measurement of the cosmic ray proton and helium spectra by the PAMELA experiment performed using the "thin" (in terms of nuclei interactions) sampling electromagnetic calorimeter. The described method, optimized by using Monte Carlo simulation, beam test and experimental data, allows the spectra to be measured up to 10 TeV, thus extending the PAMELA observational range based on the magnetic spectrometer measurement.
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| 49. |
- Adriani, O., et al.
(author)
-
OBSERVATIONS OF THE 2006 DECEMBER 13 AND 14 SOLAR PARTICLE EVENTS IN THE 80 MeV n(-1)-3 GeV n(-1) RANGE FROM SPACE WITH THE PAMELA DETECTOR
- 2011
-
In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 742:2, s. 102-
-
Journal article (peer-reviewed)abstract
- We present the space spectrometer PAMELA observations of proton and helium fluxes during the 2006 December 13 and 14 solar particle events. This is the first direct measurement of the solar energetic particles in space with a single instrument in the energy range from similar to 80 MeV n(-1) up to similar to 3 GeV n(-1). For the December 13 event, measured energy spectra of solar protons and helium are compared with results obtained by neutron monitors and other detectors. Our measurements show a spectral behavior different from those derived from the neutron monitor network. No satisfactory analytical fitting was found for the energy spectra. During the first hours of the December 13 event, solar energetic particles spectra were close to the exponential form, demonstrating rather significant temporal evolution. Solar He with energy up to 1 GeV n(-1) was recorded on December 13. For the December 14 event, energy of solar protons reached 600 MeV, whereas the maximum energy of He was below 100 MeV n(-1). The spectra were slightly bent in the lower energy range and preserved their form during the second event. Differences in the particle flux appearance and temporal evolution of these two events may argue for special conditions leading to the acceleration of solar particles up to relativistic energies.
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| 50. |
- Adriani, O., et al.
(author)
-
PAMELA Measurements of Cosmic-Ray Proton and Helium Spectra
- 2011
-
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 332:6025, s. 69-72
-
Journal article (peer-reviewed)abstract
- Protons and helium nuclei are the most abundant components of the cosmic radiation. Precise measurements of their fluxes are needed to understand the acceleration and subsequent propagation of cosmic rays in our Galaxy. We report precision measurements of the proton and helium spectra in the rigidity range 1 gigavolt to 1.2 teravolts performed by the satellite-borne experiment PAMELA (payload for antimatter matter exploration and light-nuclei astrophysics). We find that the spectral shapes of these two species are different and cannot be described well by a single power law. These data challenge the current paradigm of cosmic-ray acceleration in supernova remnants followed by diffusive propagation in the Galaxy. More complex processes of acceleration and propagation of cosmic rays are required to explain the spectral structures observed in our data.
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