| 1. |
- Fenstermacher, M.E., et al.
(författare)
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DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
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| 5. |
- Fomalont, E. B., et al.
(författare)
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THE 2014 ALMA LONG BASELINE CAMPAIGN: AN OVERVIEW
- 2015
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 808:1
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Tidskriftsartikel (refereegranskat)abstract
- A major goal of the Atacama Large Millimeter/submillimeter Array (ALMA) is to make accurate images with resolutions of tens of milliarcseconds, which at submillimeter (submm) wavelengths requires baselines up to similar to 15 km. To develop and test this capability, a Long Baseline Campaign (LBC) was carried out from 2014 September to late November, culminating in end-to-end observations, calibrations, and imaging of selected Science Verification (SV) targets. This paper presents an overview of the campaign and its main results, including an investigation of the short-term coherence properties and systematic phase errors over the long baselines at the ALMA site, a summary of the SV targets and observations, and recommendations for science observing strategies at long baselines. Deep ALMA images of the quasar 3C 138 at 97 and 241 GHz are also compared to VLA 43 GHz results, demonstrating an agreement at a level of a few percent. As a result of the extensive program of LBC testing, the highly successful SV imaging at long baselines achieved angular resolutions as fine as 19 mas at similar to 350 GHz. Observing with ALMA on baselines of up to 15 km is now possible, and opens up new parameter space for submm astronomy.
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| 6. |
- Reimerdes, H., et al.
(författare)
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Overview of the TCV tokamak experimental programme
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- The tokamak a configuration variable (TCV) continues to leverage its unique shaping capabilities, flexible heating systems and modern control system to address critical issues in preparation for ITER and a fusion power plant. For the 2019-20 campaign its configurational flexibility has been enhanced with the installation of removable divertor gas baffles, its diagnostic capabilities with an extensive set of upgrades and its heating systems with new dual frequency gyrotrons. The gas baffles reduce coupling between the divertor and the main chamber and allow for detailed investigations on the role of fuelling in general and, together with upgraded boundary diagnostics, test divertor and edge models in particular. The increased heating capabilities broaden the operational regime to include T (e)/T (i) similar to 1 and have stimulated refocussing studies from L-mode to H-mode across a range of research topics. ITER baseline parameters were reached in type-I ELMy H-modes and alternative regimes with 'small' (or no) ELMs explored. Most prominently, negative triangularity was investigated in detail and confirmed as an attractive scenario with H-mode level core confinement but an L-mode edge. Emphasis was also placed on control, where an increased number of observers, actuators and control solutions became available and are now integrated into a generic control framework as will be needed in future devices. The quantity and quality of results of the 2019-20 TCV campaign are a testament to its successful integration within the European research effort alongside a vibrant domestic programme and international collaborations.
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| 7. |
- Chatzikonstantinou, T, et al.
(författare)
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COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study
- 2021
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 35:12, s. 3444-3454
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Tidskriftsartikel (refereegranskat)abstract
- Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
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| 8. |
- Andreani, P., et al.
(författare)
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The European ALMA Regional Centre: a model of user support
- 2014
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. - 9780819496171 ; 9149, s. Art. no. 91490Y-
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Konferensbidrag (refereegranskat)abstract
- The ALMA Regional Centres (ARCs) form the interface between the ALMA observatory and the user community from the proposal preparation stage to the delivery of data and their subsequent analysis. The ARCs provide critical services to both the ALMA operations in Chile and to the user community. These services were split by the ALMA project into core and additional services. The core services are financed by the ALMA operations budget and are critical to the successful operation of ALMA. They are contractual obligations and must be delivered to the ALMA project. The additional services are not funded by the ALMA project and are not contractual obligations, but are critical to achieve ALMA full scientific potential. A distributed network of ARC nodes (with ESO being the central ARC) has been set up throughout Europe at the following seven locations: Bologna, Bonn-Cologne, Grenoble, Leiden, Manchester, Ondrejov, Onsala. These ARC nodes are working together with the central node at ESO and provide both core and additional services to the ALMA user community. This paper presents the European ARC, and how it operates in Europe to support the ALMA community. This model, although complex in nature, is turning into a very successful one, providing a service to the scientific community that has been so far highly appreciated. The ARC could become a reference support model in an age where very large collaborations are required to build large facilities, and support is needed for geographically and culturally diverse communities.
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| 9. |
- Abdulhamid, M. I., et al.
(författare)
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Azimuthal correlations of high transverse momentum jets at next-to-leading order in the parton branching method
- 2022
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 82:1
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Tidskriftsartikel (refereegranskat)abstract
- The azimuthal correlation, Δ ϕ12, of high transverse momentum jets in pp collisions at s=13 TeV is studied by applying PB-TMD distributions to NLO calculations via MCatNLO together with the PB-TMD parton shower. A very good description of the cross section as a function of Δ ϕ12 is observed. In the back-to-back region of Δ ϕ12→ π, a very good agreement is observed with the PB-TMD Set 2 distributions while significant deviations are obtained with the PB-TMD Set 1 distributions. Set 1 uses the evolution scale while Set 2 uses transverse momentum as an argument in αs, and the above observation therefore confirms the importance of an appropriate soft-gluon coupling in angular ordered parton evolution. The total uncertainties of the predictions are dominated by the scale uncertainties of the matrix element, while the uncertainties coming from the PB-TMDs and the corresponding PB-TMD shower are very small. The Δ ϕ12 measurements are also compared with predictions using MCatNLO together Pythia8, illustrating the importance of details of the parton shower evolution.
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| 10. |
- Das, Y, et al.
(författare)
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Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice
- 2021
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Ingår i: Frontiers in cell and developmental biology. - : Frontiers Media SA. - 2296-634X. ; 9, s. 632930-
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Tidskriftsartikel (refereegranskat)abstract
- Patients lacking multifunctional protein 2 (MFP2), the central enzyme of the peroxisomal β-oxidation pathway, develop retinopathy. This pathway is involved in the metabolism of very long chain (VLCFAs) and polyunsaturated (PUFAs) fatty acids, which are enriched in the photoreceptor outer segments (POS). The molecular mechanisms underlying the retinopathy remain, however, elusive. Here, we report that mice with MFP2 inactivation display decreased retinal function already at the age of 3 weeks, which is accompanied by a profound shortening of the photoreceptor outer and inner segments, but with preserved photoreceptor ultrastructure. Furthermore, MFP2 deficient retinas exhibit severe changes in gene expression with downregulation of genes involved in the phototransduction pathway and upregulation of inflammation related genes. Lipid profiling of the mutant retinas revealed a profound reduction of DHA-containing phospholipids. This was likely due to a hampered systemic supply and retinal traffic of this PUFA, although we cannot exclude that the local defect of peroxisomal β-oxidation contributes to this DHA decrease. Moreover, very long chain PUFAs were also reduced, with the exception of those containing ≥ 34 carbons that accumulated. The latter suggests that there is an uncontrollable elongation of retinal PUFAs. In conclusion, our data reveal that intact peroxisomal β-oxidation is indispensable for retinal integrity, most likely by maintaining PUFA homeostasis.
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| 11. |
- Antonuccio-Delogu, V., et al.
(författare)
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Properties of galaxy haloes in clusters and voids
- 2002
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Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 332:1, s. 7-20
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Tidskriftsartikel (refereegranskat)abstract
- We use the results of a high-resolution N -body simulation to investigate the role of the environment on the formation and evolution of galaxy-sized haloes. Starting from a set of constrained initial conditions, we have produced a final configuration hosting a double cluster in one octant and a large void extending over two octants of the simulation box. In this paper we concentrate on gravitationally bound galaxy-sized haloes extracted from these two regions and from a third region hosting a single, relaxed cluster without substructure. Exploiting the high mass resolution of our simulation (m body =2.1×109 h -1 Msolar ), we construct halo samples probing more than two decades in mass, starting from a rather small mass threshold: 5×1010 h -1 Msolar =34.2r 0 , where r 0 is the core radius of the TIS solution). We do, however, find a dependence of this relationship on the environment, like for the P (lambda ) statistics. These facts hint at a possible role of tidal fields in determining the statistical properties of haloes.
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| 12. |
- Bručas, Rimantas, et al.
(författare)
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Magnetic and transport properties of Ni81Fe19/Al2O3 granular multilayers approaching the superparamagnetic limit
- 2007
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 101:7, s. 073907-
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Tidskriftsartikel (refereegranskat)abstract
- The magnetic and transport properties of Ni81Fe 19/Al2O3 granular multilayer films were studied in relation to their structural properties as the nominal thickness t of the permalloy (Ni81Fe19) layer was varied near the percolation limit: in the range of 8≤t≤ 16 Å while keeping the nominal thickness of the Al2O3 layers constant at 16 Å. A good structural quality of the multilayers was demonstrated by low angle x-ray reflectivity measurements, and transmission electron microscopy showed the transition from continuous permalloy layers separated by aluminium oxide layers for t= 16 Å to metal grains dispersed in the insulator at t=8 Å. Magnetization measurements showed the gradual transition from ferromagnetic layers to superparamagnetic clusters and grains that successively become blocked as the temperature decreases. A strong correlation between transport and structural properties was observed in the temperature (T) dependence of the electrical resistance measured with the current in the plane in the range of 2 ≤T≤300 K: a gradual change of behavior from continuous permalloy layers with conducting interlayer connections for t=16 Å. to isolated permalloy grains in a dielectric for the film with t= 10 Å. The percolation occurs between 12 and 10 Å, as deduced both from the magnetic and resistive properties. The discontinuous metal films were analyzed within models for thermally assisted tunneling, yielding estimates of the tunneling barrier for intralayer conduction of about 20 meV for t= 10 Å. A significant magnetic field dependence of the resistance increasing with decreasing temperature was observed in all samples.
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| 14. |
- Muller, Sebastien, 1976, et al.
(författare)
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Cosmo-tomography toward PKS 1830-211: Variability of the quasar and of its foreground molecular absorption monitored with ALMA
- 2023
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 674
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Tidskriftsartikel (refereegranskat)abstract
- Context. Time variability of astronomical sources provides crude information on their typical size and on the implied physical mechanisms. PKS 1830-211 is a remarkable radio-bright lensed quasar with a foreground molecular absorber in the lens galaxy at z = 0.89. Small-scale morphological changes in the core- jet structure of the quasar - which is magnified by the lensing - result in a varying illumination of the absorber screen, which in turn causes variations in the absorption profile. Aims. We aim to study the time variations of the system (the two main lensed images of the quasar and the two corresponding sightlines in the absorber) in order to obtain constraints on both the quasar activity and small-scale structures in the interstellar medium of the absorber. Methods. We used ALMA to monitor the submillimeter continuum emission of PKS 1830-211, together with the absorption spectra of the H2O and CH molecules, with 17 visits spread over six months in 2016. Complementing this, we used available ALMA data to investigate changes in the system in the period 2012-2022. Results. From the continuum data, we followed the evolution of the flux density, flux-density ratio, spectral index, and differential polarization between the two lensed images of the quasar; all quantities show significant variations related to the intrinsic activity of the quasar. We propose a simple parametric model of a core plus a ballistic plasmon to account for the continuum evolution, from which we constrain a time delay of 25 ± 3 days between main lensed images. The spectral lines reveal significant variations in the foreground absorption profile. A principal component analysis highlights apparent wavy time variations, possibly linked to the helical jet precession period of the quasar. From the deep averaged spectra towards the southwest image, we detect the absorption of the rare isotopolog 13CH and estimate an abundance ratio of 12CH/13CH ∼ 150. We also measure the oxygen isotopic ratios, 16O/18O = 65.3 ± 0.7 and 18O/17O = 11.5 ± 0.5 in the z = 0.89 absorber. Finally, we find a remarkable continuous shallow trough in the water absorption spanning a velocity interval of nearly 500 km s-1. This broad absorption could be the signature of an extra-planar molecular component. Conclusions. All together, the system formed by the quasar PKS 1830-211 and its foreground lens- absorber acts as a powerful gravitational microscope, providing us with the possibility to dissect small-scale structures in both the ISM of the foreground absorber and the jet of the background quasar.
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| 15. |
- Schagatay, E, et al.
(författare)
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Effects of repeated apneas on apneic time and diving response in non-divers
- 1999
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Ingår i: Undersea & Hyperbaric Medicine. - 1066-2936. ; 26:3, s. 9-143
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Tidskriftsartikel (refereegranskat)abstract
- Human breath-hold divers usually perform a series of dives with short intervals. Repeated apneas prolong apneic time, and an accentuated diving response has been suggested to be the cause. The aim of this study was to investigate the effect of repeated apneas on apneic time and diving response in humans. Forty-one subjects performed a series of five apneas with face immersion in water of 10 degrees C, separated by 2-min intervals. Apneas were performed at rest and to individual maximal duration. Heart rate, mean arterial pressure, skin capillary blood flow, and respiratory movements were recorded. Thirty-eight of the subjects were used for analysis of cardiovascular parameters, and in 23 subjects the physiologic breaking point could be detected by the involuntary breathing movements. Heart rate reduction and blood pressure increase were most prominent during the first apneic face immersion, whereas skin capillary blood flow reduction was most intense in the second apneic face immersion. Blood pressure and skin capillary blood flow during recovery from apneic episodes also changed throughout the series. Repetition increased apneic time by 55% and postponed the occurrence of involuntary breathing movements by 27% in subjects passing the physiologic breaking point. We conclude that both physiologic factors, associated with the accumulation of CO2, and psychologic factors, related to the capacity to withstand the respiratory drive, contribute to the prolongation of apneic time whereas an increased diving response does not contribute.
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