| 1. |
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| 2. |
- Akkoyun, S., et al.
(författare)
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AGATA - Advanced GAmma Tracking Array
- 2012
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 0167-5087 .- 1872-9576. ; 668, s. 26-58
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Tidskriftsartikel (refereegranskat)abstract
- The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation γ-ray spectrometer. AGATA is based on the technique of γ-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a γ ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of γ-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector- response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. © 2011 Elsevier B.V. All rights reserved.
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| 3. |
- van Cappellen, W., et al.
(författare)
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Apertif: Phased array feeds for the Westerbork Synthesis Radio Telescope: System overview and performance characteristics
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 658
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Tidskriftsartikel (refereegranskat)abstract
- We describe the APERture Tile In Focus (Apertif) system, a phased array feed (PAF) upgrade of the Westerbork Synthesis Radio Telescope that transforms this telescope into a high-sensitivity, wide-field-of-view L-band imaging and transient survey instrument. Using novel PAF technology, up to 40 partially overlapping beams are formed on the sky simultaneously, significantly increasing the survey speed of the telescope. With this upgraded instrument, an imaging survey covering an area of 2300 deg2 is being performed that will deliver both continuum and spectral line datasets, of which the first data have been publicly released. In addition, a time domain transient and pulsar survey covering 15 000 deg2 is in progress. An overview of the Apertif science drivers, hardware, and software of the upgraded telescope is presented, along with its key performance characteristics.
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| 4. |
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| 5. |
- Lieder, R M, et al.
(författare)
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Gamma-ray tracking arrays
- 2001
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Ingår i: PROGRESS IN PARTICLE AND NUCLEAR PHYSICS, VOL 46. ; , s. 399-407
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Konferensbidrag (refereegranskat)abstract
- The next generation of 4 pi arrays for high-precision gamma -ray spectroscopy will involve "gamma -ray tracking front-end on digital signal processing techniques, which allows to extract energy, timing and spatial information on the interactions of a gamma -ray in the Ge detector by pulse shape analysis of its signals. Utilizing the information on the positions of the interaction points and the energies released at each point the tracks of the gamma -rays in a Ge shell can be reconstructed in three dimensions.
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| 6. |
- Purdue, Mark P, et al.
(författare)
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Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:1, s. 60-65
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Tidskriftsartikel (refereegranskat)abstract
- We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 × 10⁻¹⁴). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 × 10⁻⁸). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.
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| 7. |
- Ardizzone, I., et al.
(författare)
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Optical properties of LaNi O3 films tuned from compressive to tensile strain
- 2020
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Ingår i: Physical Review B. - : American Physical Society. - 2469-9969 .- 2469-9950. ; 102:15
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Tidskriftsartikel (refereegranskat)abstract
- Materials with strong electronic correlations host remarkable - and technologically relevant - phenomena such as magnetism, superconductivity, and metal-insulator transitions. Harnessing and controlling these effects is a major challenge, on which key advances are being made through lattice and strain engineering in thin films and heterostructures, leveraging the complex interplay between electronic and structural degrees of freedom. Here we show that the electronic structure of LaNiO3 can be tuned by means of lattice engineering. We use different substrates to induce compressive and tensile biaxial epitaxial strain in LaNiO3 thin films. Our measurements reveal systematic changes of the optical spectrum as a function of strain and, notably, an increase of the low-frequency free carrier weight as tensile strain is applied. Using density functional theory (DFT) calculations, we show that this apparently counterintuitive effect is due to a change of orientation of the oxygen octahedra. The calculations also reveal drastic changes of the electronic structure under strain, associated with a Fermi surface Lifshitz transition. We provide an online applet to explore these effects. The experimental value of integrated spectral weight below 2 eV is significantly (up to a factor of 3) smaller than the DFT results, indicating a transfer of spectral weight from the infrared to energies above 2 eV. The suppression of the free carrier weight and the transfer of spectral weight to high energies together indicate a correlation-induced band narrowing and free carrier mass enhancement due to electronic correlations. Our findings provide a promising avenue for the tuning and control of quantum materials employing lattice engineering.
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| 8. |
- Sanchez-Crespo, A., et al.
(författare)
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Proton therapy beam dosimetry with silicon CMOS image sensors
- 2004
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 525:02-jan, s. 289-293
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Tidskriftsartikel (refereegranskat)abstract
- A 16 mm(2) CMOS Image Sensor with more than 100 000 pixels and with a standard video output was irradiated with 48, 95 and 180 MeV protons. Proton-induced nuclear reactions in silicon were detected as bright spots or tracks in the images. The angular and energy-dependent response of the detector were studied. The application to proton dosimetry is discussed.
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| 9. |
- Sipos, A., et al.
(författare)
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Visualization of neutron and proton induced particle production in a CMOS image sensor
- 2003
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 509:03-jan, s. 328-332
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Tidskriftsartikel (refereegranskat)abstract
- A commercially available off the shelf CMOS Image Sensor was irradiated with neutron and proton beams. The Image Sensor is equipped with standard video output. The data were collected on VHS videotapes and analyzed off-line after digitization. The camera chip with 110 000 pixels each having 12 x 12 mum(2) size, shows the nuclear reactions occurring in the sensitive layer as bright spots or tracks. Several applications are suggested based on the inexpensive CMOS Image Sensor.
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| 10. |
- Vegh, J., et al.
(författare)
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Visualization of heavy ion-induced charge production in a CMOS image sensor
- 2004
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 525:02-jan, s. 229-235
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Tidskriftsartikel (refereegranskat)abstract
- A commercial CMOS image sensor was irradiated with heavy ion beams in the several MeV energy range. The image sensor is equipped with a standard video output. The data were collected on-line through frame grabbing and analysed off-line after digitisation. It was shown that the response of the image sensor to the heavy ion bombardment varied with the type and energy of the projectiles. The sensor will be used for the CMS Barrel Muon Alignment system.
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| 11. |
- Bäck, Torbjörn, et al.
(författare)
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A TOF-PET system for educational purposes
- 2002
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576. ; 477, s. 82-82
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Tidskriftsartikel (refereegranskat)abstract
- A TOF-PET system has been designed and constructed for educational purposes. The aim of this system is to demonstrate the possibilities of positron emission tomography in general and the time-of-flight method in particular to the students of various courses at the Royal Institute of Technology, Stockholm, Sweden. The set-up consists of 48 small BaF2 crystals coupled to fast photomultipliers placed in a ring geometry. The signals of the photomultipliers are fed into fast constant fraction discriminators (CFD). The outputs of these are directed to a specially designed logic VME unit. which combines the CFD signals of 6 neighbouring channels to one signal by adding a different delay to each channel. The logic circuitry produces a prompt pulse for each event that serves as the start pulse for the 8-channel fast TDC. The delayed pulses act as the stop pulses for the TDC. In a computer. the measured times are converted into information about which the photomultipliers fired with the difference in the time of flight. The set-up is described and the results are presented.
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| 12. |
- Bäck, Torbjörn, et al.
(författare)
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An educational tool for demonstrating the TOF-PET technique
- 2001
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : AMERICAN PHYSICAL SOC. - 0168-9002 .- 1872-9576. ; 471:1-2, s. 200-204
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Tidskriftsartikel (refereegranskat)abstract
- A detector system for positron emission tomography with time-of-flight capability has been built to serve as an educational tool for undergraduate students. The set-up consists of 48 BaF2 scintillator crystals, each coupled to a fast photo-multiplier tube, mounted in a circular geometry. The analogue detector pulses are handled by fast constant fraction discriminators. A dedicated unit reduces the 48 channels to eight channels via delay-fine encoding, and the signals are then fed to an eight channel fast time-to-digital converter. A VME processor sorts the events and sends them to a workstation where the coincident events are extracted. The time resolution of the detectors together with fast VME based electronics allows for time-of-flight measurements to improve on the signal-to-noise ratio in the, reconstructed images. The system can be used for different types of exercises for the students, varying from the fundamentals of scintillator detectors to advanced image reconstruction. The set-up is described and some results are presented. (C) 2001 Elsevier Science B.V. All rights reserved.
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| 13. |
- Fletcher, Erika, et al.
(författare)
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Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System
- 2018
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Ingår i: Journal of Immunology. - : AMER ASSOC IMMUNOLOGISTS. - 0022-1767 .- 1550-6606. ; 201:1, s. 87-97
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Tidskriftsartikel (refereegranskat)abstract
- Enhancing T cell responses against both viral and tumor Ags requires efficient costimulation and directed delivery of peptide Ags into APCs. Long peptide vaccines are considered favorable vaccine moieties from a clinical perspective, as they can harbor more than one immunogenic epitope enabling treatment of a broader target population. In addition, longer peptides are not extracellularly loaded on MHC class I; rather, they require intracellular processing and will thereby be presented to T cells mainly by professional APCs, thereby avoiding the risk of tolerance induction. The drawback of peptide vaccines regardless of peptide length is that naked peptides are not actively targeted to and taken up by APCs, and the standard nonconjugated adjuvant-peptide mixtures do not ensure cotargeting of the two to the same APC. We have identified a tetanus toxin-derived B cell epitope that can mediate the formation of immune complexes in the presence of circulating Abs. In this study, we show that these immune complexes improve both Ag uptake by APCs (blood monocytes and CD1c(+) dendritic cells) and consequently improve CD8(+) T cell recall responses in a human ex vivo blood loop system. The uptake of the peptide conjugate by blood monocytes is dependent on Abs and the complement component C1q. We envision that this strategy can be used to facilitate active uptake of Ags into APCs to improve T cell responses against pathogens or cancer.
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| 14. |
- Perryman, M.A.P., et al.
(författare)
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The Hipparcos Catalogue
- 2009
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Ingår i: Astronomy & Astrophysics. ; 500, s. 501-504
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Tidskriftsartikel (refereegranskat)
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| 15. |
- Stanoiu, M., et al.
(författare)
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Study of drip line nuclei through two-step fragmentation
- 2004
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 20:1, s. 95-96
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Tidskriftsartikel (refereegranskat)abstract
- We have studied the structure of light neutron-rich nuclei around N = 16 by employing the in-beam gamma-ray spectroscopy technique using the fragmentation of secondary beams of Ne-25,Ne-26, Na-27,Na-28 and Mg-29,Mg-30 isotopes. This secondary-beam cocktail was obtained by the fragmentation of a 36 S beam at 77.5 MeV.A by the SISSI/GANIL facility. By a second-step fragmentation, we have measured gamma-ray-residue coincidences in C17-20 and O-23,O-24 and described the obtained levels in the framework of the shell model.
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| 16. |
- Abromaitis, V., et al.
(författare)
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Effect of shear stress and carbon surface roughness on bioregeneration and performance of suspended versus attached biomass in metoprolol-loaded biological activated carbon systems
- 2017
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Ingår i: Chemical Engineering Journal. - : Elsevier. - 1385-8947 .- 1873-3212. ; 317, s. 503-511
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Tidskriftsartikel (refereegranskat)abstract
- The bioregeneration of activated carbon (AC) in biological activated carbon (BAC) systems is limited by sorption-desorption hysteresis and transport between the adsorbent and biomass. In this study, we investigated these limitations and whether a biofilm covering the AC surface is required. Consequently, BAC reactors were operated at different shear stress and AC surface smoothness, since this may affect biofilm formation. The experiments were carried out in BAC and blank reactors treating synthetic wastewater containing the pharmaceutical metoprolol. After start-up, all reactors removed metoprolol completely; however, after 840 h the removal dropped due to saturation of the AC. In the blank reactors, the removal dropped to 0% while in the BAC reactors removal recovered to >99%, due to increased biological activity. During the initial phase, the metoprolol was adsorbed, rather than biodegraded. At the end, the AC from the BAC reactors had higher pore volume and sorption capacity than from the blank reactors, showing that the AC had been bioregenerated. At high shear (G = 25 s(-1)), the rough AC granules (R-a = 13 mu m) were covered with a 50-400 gm thick biofilm and the total protein content of the biofilm was 2.6 mg/gAC, while at lower shear (G = 8.8 s(-1)) the rough AC granules were only partly covered. The biofilm formation at lower shear (G = 8.8 s(-1)) on smooth AC granules (R-a = 1.6 mu m) was negligible. However, due to the presence of suspended biomass the reactor performance or bioregeneration were not reduced. This showed that direct contact between the AC and biomass was not essential in mixed BAC systems. The microbial analyses of the suspended biomass and the biofilm on AC surface indicated that metoprolol was mainly biodegraded in suspension. (C) 2017 Elsevier B.V. All rights reserved.
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| 17. |
- Appelgren, J., et al.
(författare)
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Disc population synthesis : Decrease in the solid mass reservoir through pebble drift
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 673
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Tidskriftsartikel (refereegranskat)abstract
- Surveys of star-forming regions reveal that the dust mass of protoplanetary discs decreases by several orders of magnitude on timescales of a few million years. This decrease in the mass budget of solids is likely due to the radial drift of millimetre (mm) sized solids, called pebbles, induced by gas drag. However, quantifying the evolution of this dust component in young stellar clusters is difficult due to the inherent large spread in stellar masses and formation times. Therefore, we aim to model the collective evolution of a cluster to investigate the effectiveness of radial drift in clearing the discs of mm-sized particles. We use a protoplanetary disc model that provides a numerical solution for the disc formation, as well as the viscous evolution and photoevaporative clearing of the gas component, while also including the drift of particles limited in size by fragmentation. We find that discs are born with dust masses between 50 M· and 1000 M·, for stars with masses, respectively, between 0.1 M· and 1 M·. The majority of this initial dust reservoir is typically lost through drift before photoevaporation opens a gap in the gas disc for models both with and without strong X-ray-driven mass-loss rates. We conclude that the decrease in time of the mass locked in fragmentation-limited pebbles is consistent with the evolution of dust masses and ages inferred from nearby star-forming regions, when assuming viscous evolution rates corresponding to mean gas disc lifetimes between 3 Myr and 8 Myr.
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| 18. |
- Follette, Katherine B., et al.
(författare)
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SEEDS ADAPTIVE OPTICS IMAGING OF THE ASYMMETRIC TRANSITION DISK OPH IRS 48 IN SCATTERED LIGHT
- 2015
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 798:2
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Tidskriftsartikel (refereegranskat)abstract
- We present the first resolved near-infrared imagery of the transition disk Oph IRS 48 (WLY 2-48), which was recently observed with ALMA to have a strongly asymmetric submillimeter flux distribution. H-band polarized intensity images show a similar to 60 AU radius scattered light cavity with two pronounced arcs of emission, one from northeast to southeast and one smaller, fainter, and more distant arc in the northwest. K-band scattered light imagery reveals a similar morphology, but with a clear third arc along the southwestern rim of the disk cavity. This arc meets the northwestern arc at nearly a right angle, revealing the presence of a spiral arm or local surface brightness deficit in the disk, and explaining the east-west brightness asymmetry in the H-band data. We also present 0.8-5.4 mu m IRTF SpeX spectra of this object, which allow us to constrain the spectral class to A0 +/- 1 and measure a low mass accretion rate of 10(-8.5) M-circle dot yr(-1), both consistent with previous estimates. We investigate a variety of reddening laws in order to fit the multiwavelength spectral energy distribution of Oph IRS 48 and find a best fit consistent with a younger, higher luminosity star than previous estimates.
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| 19. |
- Slunga, E., et al.
(författare)
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Scintillation response of BaF2 and YAlO3 : Ce (YAP : Ce) to energetic ions
- 2001
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 469:1, s. 70-76
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Tidskriftsartikel (refereegranskat)abstract
- The scintillation response of BaF2 and YAP: Ce to protons. a particles, O-16 and Si-28 ions in the 5-30 MeV range has been investigated. The ratio between the fast and slow parts of the scintillator signal for BaF2 has been used to separate protons, a particles and heavier ions, and the dependence of this ratio on the particle energy has been studied. The time constants and intensities of the two components of the YAP: Ce signal were measured, as were the time constant and intensity of the weak component of the slow part of the BaF2 signal. Furthermore, the dependence of the light yield on the particle energy has been investigated for both BaF2 and YAP: Ce.
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| 20. |
- van der Marel, J, et al.
(författare)
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Backtracking as a way to reconstruct Compton scattered gamma-rays
- 1999
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576. ; 437:2-3, s. 538-551
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Tidskriftsartikel (refereegranskat)abstract
- A method has been developed to reconstruct the tracks of gamma-rays that have undergone Compton scattering in a high-resolution detector system. The development of this method is focussed on applications in nuclear gamma-ray spectroscopy. In nuclear in-beam gamma-ray spectroscopy a number of (position-sensitive) germanium detectors are placed around a target where the nuclei under investigation are produced. The gamma-rays emitted by the nuclei can have energies up to several MeVs. The nuclear reactions in the target can cause emission of up to 25 coincident gamma-rays and sometimes even more. In order to resolve the individual gamma-rays from such events the detector systems currently under development will have such a high granularity that the energy of scattered gamma-ray will be deposited in several different detector segments. Therefore, in order to determine the initial energies and the first interaction positions, the tracks have to be reconstructed. The reconstruction method presented in this paper is based on the observation that the energy deposition of the final photoelectric interaction after scattering usually falls in a narrow energy band. Starting from points in this energy range attempts are made to reconstruct the tracks using the photoelectric and Compton interaction probabilities and the Compton scattering formula. The method has been tested on simulated events with up to 25 coincident gamma-rays of various energies and with different detector position resolutions. Reconstruction efficiencies of up to 84% have been achieved. (C) 1999 Elsevier Science B.V. All rights reserved.
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| 21. |
- van der Marel, J., et al.
(författare)
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Collimatorless imaging of gamma rays with help of gamma-ray tracking
- 2001
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 471:02-jan, s. 276-280
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Tidskriftsartikel (refereegranskat)abstract
- In many gamma-ray detector systems that are built for imaging purposes Compton scattered photons are suppressed as much as possible. However, the information from photons that scattered inside a detector system can be used to reconstruct the tracks of the photons with help of gamma-ray tracking. Estimates of the incident directions of the photons can be made and an image can be created. Examples of potential applications for this technique are the use as a gamma-camera in medical imaging (e.g. SPECT) or as a detector for PET. Due to the omission of collimators, much higher detection efficiencies can be achieved, reducing the doses required for an image. A gamma-ray tracking method, called backtracking, has been developed for nuclear spectroscopy. The method tracks gamma-rays originating from a point source in the center of a spherical detector system consisting of position-sensitive germanium detectors. This method can also be used as a tracking technique for imaging of an unknown source distribution. With help of Monte Carlo simulations the method has been investigated for simple test cases with one or two planar detectors and one or two point sources. The results-show that the sources can be located accurately in three dimensions.
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| 22. |
- van der Marel, J., et al.
(författare)
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gamma-ray tracking in germanium : the backtracking method
- 2002
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 477:03-jan, s. 391-396
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Tidskriftsartikel (refereegranskat)abstract
- In the framework of a European TMR network project the concept for a gamma-ray tracking array is being developed for nuclear physics spectroscopy in the energy range of similar to 10 keV up to several MeV. The tracking array will consist of a large number of position-sensitive germanium detectors in a spherical geometry around a target. Due to the high segmentation, a Compton scattered gamma-ray will deposit energy in several different segments. A method has been developed to reconstruct the tracks of multiple coincident gamma-rays and to find their initial energies. By starting from the final point the track can be reconstructed backwards to the origin with the help of the photoelectric and Compton cross-sections and the Compton scatter formula. Every reconstructed track is given a figure of merit, thus allowing suppression of wrongly reconstructed tracks and gamma-rays that have scattered out of the detector system. This so-called backtracking method has been tested on simulated events in a shell-like geometry for germanium and in planar geometries for silicon, germanium and CdTe.
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