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- McGinn, Steven, et al.
(författare)
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New Technologies for DNA analysis-A review of the READNA Project.
- 2016
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Ingår i: New Biotechnology. - : Elsevier BV. - 1876-4347 .- 1871-6784.
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Forskningsöversikt (refereegranskat)abstract
- The REvolutionary Approaches and Devices for Nucleic Acid analysis (READNA) project received funding from the European Commission for 4 1/2 years. The objectives of the project revolved around technological developments in nucleic acid analysis. The project partners have discovered, created and developed a huge body of insights into nucleic acid analysis, ranging from improvements and implementation of current technologies to the most promising sequencing technologies that constitute a 3(rd) and 4(th) generation of sequencing methods with nanopores and in situ sequencing, respectively.
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- Mertes, Florian, et al.
(författare)
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Targeted enrichment of genomic DNA regions for next-generation sequencing
- 2011
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Ingår i: Briefings in functional genomics. - : Oxford University Press (OUP). - 2041-2649 .- 2041-2657. ; 10:6, s. 374-386
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Forskningsöversikt (refereegranskat)abstract
- In this review, we discuss the latest targeted enrichment methods and aspects of their utilization along with second-generation sequencing for complex genome analysis. In doing so, we provide an overview of issues involved in detecting genetic variation, for which targeted enrichment has become a powerful tool. We explain how targeted enrichment for next-generation sequencing has made great progress in terms of methodology, ease of use and applicability, but emphasize the remaining challenges such as the lack of even coverage across targeted regions. Costs are also considered versus the alternative of whole-genome sequencing which is becoming ever more affordable. We conclude that targeted enrichment is likely to be the most economical option for many years to come in a range of settings.
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- Boakye-Ansah, A. S., et al.
(författare)
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Inequalities in microbial contamination of drinking water supplies in urban areas : The case of Lilongwe, Malawi
- 2016
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Ingår i: Journal of Water and Health. - : IWA Publishing. - 1477-8920 .- 1996-7829. ; 14:5, s. 851-863
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Tidskriftsartikel (refereegranskat)abstract
- Over past decades strategies for improving access to drinking water in cities of the Global South have mainly focused on increasing coverage, while water quality has often been overlooked. This paper focuses on drinking water quality in the centralized water supply network of Lilongwe, the capital of Malawi. It shows how microbial contamination of drinking water is unequally distributed to consumers in low-income (unplanned areas) and higher-income neighbourhoods (planned areas). Microbial contamination and residual disinfectant concentration were measured in 170 water samples collected from in-house taps in high-income areas and from kiosks and water storage facilities in low-income areas between November 2014 and January 2015. Faecal contamination (Escherichia coli) was detected in 10% of the 40 samples collected from planned areas, in 59% of the 64 samples collected from kiosks in the unplanned areas and in 75% of the 32 samples of water stored at household level. Differences in water quality in planned and unplanned areas were found to be statistically significant at p < 0.05. Finally, the paper shows how the inequalities in microbial contamination of drinking water are produced by decisions both on the development of the water supply infrastructure and on how this is operated and maintained.
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- Jonker, L., et al.
(författare)
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A regional and multi-faceted approach to postgraduate water education - the WaterNet experience in Southern Africa
- 2012
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Ingår i: Hydrology and Earth System Sciences. - : Copernicus GmbH. - 1027-5606 .- 1607-7938. ; 16:11, s. 4225-4232
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Tidskriftsartikel (refereegranskat)abstract
- This paper reports the experience of a regional network of academic departments involved in water education that started as a project and evolved, over a period of 12 yr, into an independent network organisation. The paper pursues three objectives. First, it argues that it makes good sense to organise postgraduate education and research on water resources on a regional scale and presents the WaterNet experience as an example that a regional approach can work. Second, it presents preliminary findings and conclusions that the regional approach presented by WaterNet did make a contribution to the capacity needs of the region both in terms of management and research capacity. Third, it draws two generalised lessons from the WaterNet experience. Lesson one pertains to the importance of legitimate ownership and an accountability structure for network effectiveness. Lesson two is related to the financial and intellectual resources required to jointly developing educational programmes through shared experience.
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