| 1. |
-
5-HT1A targeting PARCEST agent DO3AM-MPP with potential for receptor imaging : Synthesis, physico-chemical and MR studies
- 2021
-
Ingår i: Bioorganic chemistry. - : Elsevier. - 0045-2068. ; 106
-
Tidskriftsartikel (refereegranskat)abstract
- Contrast enhancement in MRI using magnetization or saturation transfer techniques promises better sensitivity, and faster acquisition compared to T-1 or T-2 contrast. This work reports the synthesis and evaluation of 5-HT1A targeted PARACEST MRI contrast agent using 1,4,7,10-tetraazacycloDOdecane-4,7,10-triacetAMide (DO3AM) as the bifunctional chelator, and 5-HT1A-antagonist methoxyphenyl piperazine (MPP) as a targeting unit. The multistep synthesis led to the MPP conjugated DO3AM with 60% yield. CEST-related physicochemical parameters were evaluated after loading DO3AM-MPP with paramagnetic MRI active lanthanides: Gadolinium (Gd-DO3AM-MPP) and Europium (Eu-DO3AM-MPP). Luminescence lifetime measurements with Eu-DO3AM-MPP and computational DFT studies using Gd-DO3AM-MPP revealed the coordination of one water molecule (q = 1.43) with metal-water distance (r(M)-H2O) of 2.7 angstrom and water residence time (tau(m)) of 0.23 ms. The dissociation constant of K-d 62 +/- 0.02 pM as evaluated from fluorescence quenching of 5-HT1A (protein) and docking score of -4.81 in theoretical evaluation reflect the binding potential of the complex Gd-DO3AM-MPP with the receptor 5-HT1A. Insights of the docked pose reflect the importance of NH2 (amide) and aromatic ring in Gd-DO3AM-MPP while interacting with Ser 374 and Phe 370 in the antagonist binding pocket of 5-HT1A. Gd-DO3AM-MPP shows longitudinal relaxivity 5.85 mM(-1)s(-1) with a water residence lifetime of 0.93 ms in hippocampal homogenate containing 5-HT1A. The potentiometric titration of DO3AM-MPP showed strong selectivity for Gd3+ over physiological metal ions such as Zn2+ and Cu2+. The in vitro and in vivo studies confirmed the minimal cytotoxicity and presential binding of Gd-DO3AM-MPP with 5-HT1A receptor in the hippocampus region of the mice. Summarizing, the complex Gd-DO3AM-MPP can have a potential for CEST imaging of 5-HT1A receptors.
|
|
| 2. |
-
5 riksantikvarer paa Røros
- 1978
-
Ingår i: Kulturminnesvård. - Stockholm : Riksantikvarieämbetet. - 0346-9077. ; :3, s. 10-11
-
Tidskriftsartikel (populärvet., debatt m.m.)
|
|
| 3. |
|
|
| 4. |
- A., Adare, et al.
(författare)
-
Transverse energy production and charged-particle multiplicity at midrapidity in various systems from sNN =7.7 to 200 GeV
- 2016
-
Ingår i: Physical Review C. - 2469-9985. ; 93:2
-
Tidskriftsartikel (refereegranskat)abstract
- Measurements of midrapidity charged-particle multiplicity distributions, dNch/dη, and midrapidity transverse-energy distributions, dET/dη, are presented for a variety of collision systems and energies. Included are distributions for Au+Au collisions at sNN=200, 130, 62.4, 39, 27, 19.6, 14.5, and 7.7 GeV, Cu+Cu collisions at sNN=200 and 62.4 GeV, Cu+Au collisions at sNN=200 GeV, U+U collisions at sNN=193 GeV, d+Au collisions at sNN=200 GeV, He3+Au collisions at sNN=200 GeV, and p+p collisions at sNN=200 GeV. Centrality-dependent distributions at midrapidity are presented in terms of the number of nucleon participants, Npart, and the number of constituent quark participants, Nqp. For all A+A collisions down to sNN=7.7 GeV, it is observed that the midrapidity data are better described by scaling with Nqp than scaling with Npart. Also presented are estimates of the Bjorken energy density, BJ, and the ratio of dET/dη to dNch/dη, the latter of which is seen to be constant as a function of centrality for all systems.
|
|
| 5. |
|
|
| 6. |
- A. Alkhamisi, Mahdi, et al.
(författare)
-
A Monte Carlo Study of Recent Ridge Parameters
- 2007
-
Ingår i: Communications in statistics. Simulation and computation. - 0361-0918 .- 1532-4141. ; 36:3, s. 535-547
-
Tidskriftsartikel (refereegranskat)
|
|
| 7. |
|
|
| 8. |
- A Asif, Farazee M, 1980-, et al.
(författare)
-
Performance analysis of the closed loop supply chain
- 2012
-
Ingår i: Journal of Remanufacturing. - Germany : Springer Science and Business Media LLC. - 2210-4690. ; 2:4
-
Tidskriftsartikel (refereegranskat)abstract
- PurposeThe question of resource scarcity and emerging pressure of environmental legislations has brought a new challenge for the manufacturing industry. On the one hand, there is a huge population that demands a large quantity of commodities; on the other hand, these demands have to be met by minimum resources and pollution. Resource conservative manufacturing (ResCoM) is a proposed holistic concept to manage these challenges. The successful implementation of this concept requires cross functional collaboration among relevant fields, and among them, closed loop supply chain is an essential domain. The paper aims to highlight some misconceptions concerning the closed loop supply chain, to discuss different challenges, and in addition, to show how the proposed concept deals with those challenges through analysis of key performance indicators (KPI).MethodsThe work presented in this paper is mainly based on the literature review. The analysis of performance of the closed loop supply chain is done using system dynamics, and the Stella software has been used to do the simulation. Findings The results of the simulation depict that in ResCoM; the performance of the closed loop supply chain is much enhanced in terms of supply, demand, and other uncertainties involved. The results may particularly be interesting for industries involved in remanufacturing, researchers in the field of closed loop supply chain, and other relevant areas. Originality The paper presented a novel research concept called ResCoM which is supported by system dynamics models of the closed loop supply chain to demonstrate the behavior of KPI in the closed loop supply chain.
|
|
| 9. |
- A Atlasov, Kirill, et al.
(författare)
-
1D photonic band formation and photon localization in finite-size photonic-crystal waveguides
- 2010
-
Ingår i: OPTICS EXPRESS. - 1094-4087. ; 18:1, s. 117-122
-
Tidskriftsartikel (refereegranskat)abstract
- A transition from discrete optical modes to 1D photonic bands is experimentally observed and numerically studied in planar photonic-crystal (PhC) L-N microcavities of length N. For increasing N the confined modes progressively acquire a well-defined momentum, eventually reconstructing the band dispersion of the corresponding waveguide. Furthermore, photon localization due to disorder is observed experimentally in the membrane PhCs using spatially resolved photoluminescence spectroscopy. Implications on single-photon sources and transfer lines based on quasi-1D PhC structures are discussed.
|
|
| 10. |
- A. B. Marçal, L., et al.
(författare)
-
Spatially resolved structural and chemical properties of the white layer in machined Inconel 718 super alloy
- 2024
-
Ingår i: Materials and Design. - 0264-1275. ; 239
-
Tidskriftsartikel (refereegranskat)abstract
- Inconel 718 is one type of nickel-based alloy used for a large range of applications, including gas turbines and aeroengines components. Although mechanical and thermodynamic properties of this material have been deeply studied in the past years, a method able to investigate local properties of the thin white layer formed on the alloy surface after machining remains challenging. Here, a 90 nm X-ray beam is used to probe the local strain, crystal orientation, and chemical composition of grains in the white layer. Data reveals mosaicity induced by the tool during machining. The high spatial resolution, combined with crystal lattice sensitivity, shows that the average grain size is around 30 nm throughout the white layer, while the strain is anisotropic nearest to the surface. Results provide new insights on the basic properties of the white layer in super alloys, revealing important information about the impact of finish machining which might help to explain fatigue and cracking formation on these materials during their usage phase.
|
|
| 11. |
|
|
| 12. |
- A. Bateki, Christian, et al.
(författare)
-
Of milk and mobiles: Assessing the potential of cellphone applications to reduce cattle milk yield gaps in Africa using a case study
- 2021
-
Ingår i: Computers and Electronics in Agriculture. - : Elsevier BV. - 0168-1699. ; 191
-
Tidskriftsartikel (refereegranskat)abstract
- There are growing expectations that Information and Communication Technology (ICT) applications could help improve on-farm yields amongst smallholder farmers in developing countries, and consequently, food and nutrition security. However, few studies have quantified the actual contribution of ICT applications on farmers’ yields, and these studies predominantly focused on crop production. We assessed the potential of ICT applications to close milk yield gaps among small- and medium scale dairy cattle farmers in Africa. First, we developed a theoretical framework summarizing biophysical and socio-economic constraints that foster milk yield gaps and discussed which constraints can be addressed using ICT applications. Second, using a case study of a feeding advice application for dairy cattle pre-tested with farmers in rural Kenya, we analyzed how much stand-alone the application could contribute to close dairy cattle milk yield gaps. Our findings suggest that ICT applications could help address some existing biophysical and socio-economic constraints fostering milk yield gaps, including data collection for breeding programs, feeding management advice, and facilitating access to markets and capital. Our stand-alone ICT application closed yield gaps by 2 % to 6 % on representative farms. Several factors may explain the limited actual contribution of selected ICT applications to reduce existing milk yield gaps, including the quality of the input data and models used in ICT applications, and more structural constraints that cannot be addressed by digital tools. Therefore, although ICT applications could help address constraints to achieving higher milk yields on dairy farms, a significant contribution to improve yields may only be achieved when conditions surrounding their use are adequate.
|
|
| 13. |
|
|
| 14. |
- A, Dell'Isola, et al.
(författare)
-
The role of pain and walking difficulties in shaping willingness to undergo joint surgery for osteoarthritis: Data from the Swedish BOA register
- 2021
-
Ingår i: Osteoarthritis and Cartilage Open. - : Elsevier BV. - 2665-9131. ; 3:2
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: To investigate whether the association between pain intensity and willingness to undergo surgery is explained by walking difficulties, in patients with knee or hip osteoarthritis (OA). Methods: This is an observational study using data from the Better management of patients with Osteoarthritis (BOA) register, which collects data from a publicly financed self-management programme for people with OA in Sweden. We included all patients with knee or hip OA who attended the baseline visit between 2008 and 2016. We conducted separate mediation analyses within a counterfactual framework to estimate the mediation effect of walking difficulties (yes/no) on willingness to undergo surgery (yes/no) for each one-point increase in pain (0–10 on a numeric rating scale), adjusted for relevant confounders. Results: We included 72,131 patients (69% women, mean age 66, mean pain 5.4, 81% had walking difficulties, 27% was willing to undergo surgery). A one-point increase in pain intensity was associated with 1.53 (95% CI: 1.51; 1.55) higher odds of being willing to undergo surgery. Walking difficulties mediated 10%–25% of the effect of one-point increase in pain when pain was <8/10, while at pain ≥8/10 this percentage decreased to 3%. Conclusions: More than 80% of the BOA patients have mild to moderate pain (<8/10) and walking difficulties can mediate up to a quarter of the total effect of pain on the willingness to undergo surgery in these patients. Trials to evaluate the potential to lower surgery demand by reducing walking difficulties in people with these characteristics are needed.
|
|
| 15. |
- A. da Cruz, Márcia G., et al.
(författare)
-
Electrochemical Depolymerization of Lignin in a Biomass-based Solvent
- 2022
-
Ingår i: ChemSusChem. - : Wiley. - 1864-5631 .- 1864-564X. ; 15:15
-
Tidskriftsartikel (refereegranskat)abstract
- Breaking down lignin into smaller units is the key to generate high value-added products. Nevertheless, dissolving this complex plant polyphenol in an environment-friendly way is often a challenge. Levulinic acid, which is formed during the hydrothermal processing of lignocellulosic biomass, has been shown to efficiently dissolve lignin. Herein, levulinic acid was evaluated as a medium for the reductive electrochemical depolymerization of the lignin macromolecule. Copper was chosen as the electrocatalyst due to the economic feasibility and low activity towards the hydrogen evolution reaction. After depolymerization, high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy revealed lignin-derived monomers and dimers. A predominance of aryl ether and phenolic groups was observed. Depolymerized lignin was further evaluated as an anti-corrosion coating, revealing enhancements on the electrochemical stability of the metal. Via a simple depolymerization process of biomass waste in a biomass-based solvent, a straightforward approach to produce high value-added compounds or tailored biobased materials was demonstrated.
|
|
| 16. |
- A. da Cruz, Marcia Gabriely, et al.
(författare)
-
On the product selectivity in the electrochemical reductive cleavage of 2-phenoxyacetophenone, a lignin model compound
- 2022
-
Ingår i: Green Chemistry Letters and Reviews. - : Informa UK Limited. - 1751-8253 .- 1751-7192. ; 15:1, s. 151-159
-
Tidskriftsartikel (refereegranskat)abstract
- Research towards the production of renewable chemicals for fuel and energy industries has found lignin valorization as key. With a high carbon content and aromaticity, a fine-tuning of the depolymerization process is required to convert lignin into valuable chemicals. In context, model compounds have been used to understand the electrocatalyzed depolymerization for mimicking the typical linkages of lignin. In this investigation, 2-phenoxyacetophenone, a model compound for lignin beta-O-4 linkage, was electro-catalytically hydrogenated (ECH) in distinct three-electrode setups: an open and a membrane cell. A deep eutectic solvent based on ethylene-glycol and choline chloride was used to pursue sustainable routes to dissolve lignin. Copper was used as electrocatalyst due to the economic feasibility and low activity towards hydrogen evolution reaction (HER), a side reaction of ECH. By varying the cell type, we demonstrate a simple ECH route for the generation of different monomers and oligomers from lignin. Gas chromatography of the products revealed a higher content of carbonyl groups in those using the membrane cell, whereas the open cell produced mostly hydroxyl-end chemicals. Aiming at high value-added products, our results disclose the cell type influence on electrochemical reductive depolymerization of lignin. This approach encompasses cheap transition metal electrodes and sustainable solvents.
|
|
| 17. |
- A. da Cruz, Márcia G., et al.
(författare)
-
Solvent-free synthesis of photoluminescent carbon nanoparticles from lignin-derived monomers as feedstock
- 2023
-
Ingår i: Green Chemistry Letters and Reviews. - 1751-8253 .- 1751-7192. ; 16:1
-
Tidskriftsartikel (refereegranskat)abstract
- Photoluminescent carbon nanoparticles (CNPs), such as carbon dots (CDs), have attracted much attention owing to a unique set of properties, like high and tunable fluorescence. In this way, the use of carbon-rich lignin has been demonstrated to be a sustainable approach to producing a broad range of photoluminescent CNPs. However, the valorization of this complex polyphenol is limited when it comes to green and efficient ways of conversion. In addition, the existing solvothermal approaches using lignin often result in CDs with low photoluminescence, while flammable and/or toxic solvents are employed. Here, we depolymerized technical lignins, i.e. kraft and soda, through electroreductive cleavage in two different sustainable media: deep eutectic solvent and levulinic acid. After depolymerization, lignin-derived monomers were generated, with a predominance of aryl ether and phenolic groups, which were further combined with 1,2-Phenylenediamine to produce N-doped CNPs in a solvent-free approach. Photoluminescent CNPs with varied sizes were generated (5–50 nm), which presented a wide photoluminescence emission, from blue to red, depending on solvent polarity. These results demonstrate a feasible and sustainable route for the solvent-free synthesis of photoluminescent CNPs using lignin-derived monomers as carbon source, which may find applications in a wide range of fields.
|
|
| 18. |
|
|
| 19. |
- A Herrera, I, et al.
(författare)
-
Comparing a multi-linear (STEP) and systemic (FRAM) method for accident analysis
- 2010
-
Ingår i: RELIABILITY ENGINEERING and SYSTEM SAFETY. - London, UK : Elsevier Science B.V., Amsterdam.. - 0951-8320. ; 95:12, s. 1269-1275, s. 19-26
-
Tidskriftsartikel (refereegranskat)abstract
- Accident models and analysis methods affect what accident investigators look for, which contributory factors are found, and which recommendations are issued. This paper contrasts the Sequentially Timed Events Plotting (STEP) method and the Functional Resonance Analysis Method (FRAM) for accident analysis and modelling. The main issue addressed in this paper is the comparison of the established multi-linear method STEP with the new systemic method FRAM and which new insights the latter provides for accident analysis in comparison to the former established multi-linear method. Since STEP and FRAM are based on a different understandings of the nature of accidents, the comparison of the methods focuses on what we can learn from both methods, how, when, and why to apply them. The main finding is that STEP helps to illustrate what happened, involving which actors at what time, whereas FRAM illustrates the dynamic interactions within socio-technical systems and lets the analyst understand the how and why by describing non-linear dependencies, performance conditions, variability, and their resonance across functions.
|
|
| 20. |
- A, Komonen, et al.
(författare)
-
Insects associated with fruit bodies of the wood-decaying fungus Oak mazegill (Daedalea quercina) in mixed oak forests in southern Sweden
- 2012
-
Ingår i: Entomologisk Tidskrift. - 0013-886X. ; 133:4, s. 173-181
-
Tidskriftsartikel (refereegranskat)abstract
- Polypores host species rich insect assemblages, but relatively few polypore species have been studied in detail. We investigated insect assemblages associated with the fruit bodies of Daedalea quercina, a specialist species on oak in southern Sweden. Fruit bodies (n = 228) were collected from 25 nature reserves and woodland key habitats, and were taken into the laboratory to collect emerging insects. A total of 245 insect individuals were recorded, belonging to at least 45 species. The numerically dominant fungivores were the tineid moths Montescardia tessulatella (n = 38 individuals) and Nemapogon fungivorellus (n = 10) and the coleopteran Ennearthron cornutum (Ciidae) (n = 44). Altogether 40 individuals of hymenopteran parasitoids were recorded, belonging to Braconidae (Exothecinae, Microgastrinae and Rogadinae, altogether 6 spp.), Ichneumonidae (Banchinae, Cryptinae and Orthocentrinae, altogether 4 spp.), Torymidae (1 sp.), Perilampidae (1 sp.) and Scelionidae (1 sp.). Most of the remaining insect species are not specifically associated with fruit bodies, but occupy many types of decaying material. In conclusion, D. quercina hosted a low number of insect individuals in general and only a few coleopteran species. The fungus apparently has only one specialist species, N. fungivorellus, which is a near-threatened (NT) species on the Swedish red list; the record from Norra Vi is the first from the Jönköping. The overall low number of insect individuals and the dominance of Lepidoptera among the fungivores is possibly explained by the tough fruit bodies of D. quercina, which only moths are able to utilize; fruit bodies which had already started to rot were devoid of moths.
|
|
| 21. |
- A, Lebedev, et al.
(författare)
-
Direct photons in WA98.
- 2002
-
Ingår i: Nuclear Physics A. ; 698, s. 135-135
-
Tidskriftsartikel (refereegranskat)
|
|
| 22. |
- A, Lavanya, et al.
(författare)
-
Smart energy monitoring and power quality performance based evaluation of 100-kW grid tied PV system
- 2023
-
Ingår i: Heliyon. - 2405-8440. ; 9:6
-
Tidskriftsartikel (refereegranskat)abstract
- Globally, the demand for energy from renewable sources is growing due to the increasing electricity consumption and the pollution of fossil fuels. The government has framed various policies to facilitate green energy generation, encouraging renewable energy source usage through PV installations in multiple sectors, including educational institutions. The primary objective of this paper is to propose a methodological approach for analysing the performance of the installed PV system on the rooftop of a university building in Tamil Nadu, India. The site selected is favourable for electricity generation from PV systems with an average global solar radiation of 5.82 kWh/m2day. Solar energy changes periodically with annual and daily variations and is not steady due to seasonal changes. The step-by-step performance assessment and the annual performance of the 100-kW solar PV system, which was instituted in 2019, with the forecasted parameters, are presented in this paper. Therefore, the assessment analysis is carried out in four phases: feasibility assessment, Energy yield assessment, Life cycle assessment, and Power quality assessment. To improve the solar PV output and efficiency, considering the solar irradiation, temperature, wind velocity, etc., PV yield is measured to evaluate the PV system's energy metrics. This paper also considers the carbon credits earned, solar power generated in the location, and the payback period. The power quality assessment is carried out in this paper to test the PV plant's compliance with effective grid integration.
|
|
| 23. |
- A. Madsen, Kevin, et al.
(författare)
-
Josephson effect in a Weyl SNS junction
- 2017
-
Ingår i: Physical Review B. - 2469-9950 .- 2469-9969. ; 95:6
-
Tidskriftsartikel (refereegranskat)abstract
- We calculate the Josephson current density j (phi) for a Weyl superconductor-normal-metal-superconductor junction for which the outer terminals are superconducting Weylmetals and the normal layer is a Weyl (semi) metal. We describe the Weyl (semi) metal using a simple model with two Weyl points. The model has broken time-reversal symmetry, but inversion symmetry is present. We calculate the Josephson current for both zero and finite temperature for the two pairing mechanisms inside the superconductors that have been proposed in the literature, zero-momentum BCS-like pairing and finite-momentum FFLO-like pairing, and assuming the short-junction limit. For both pairing types we find that the current is proportional to the normal-state junction conductivity, with a proportionality coefficient that shows quantitative differences between the two pairing mechanisms. The current for the BCS-like pairing is found to be independent of the chemical potential, whereas the current for the FFLO-like pairing is not.
|
|
| 24. |
- A. Manneh, Ilana, et al.
(författare)
-
The role of anthropomorphisms in students’ reasoning about chemical structure and bonding
- 2018
-
Ingår i: Asia-Pacific Forum on Science Learning and Teaching. - 1609-4913. ; 19:2
-
Tidskriftsartikel (refereegranskat)abstract
- Anthropomorphisms are widespread at all levels of the educational system even among science experts. This has led to a shift in how anthropomorphisms are viewed in science education, from a discussion of whether they should be allowed or avoided towards an interest in their role in supporting students’ understanding of science. In this study we examine the role of anthropomorphisms in supporting students’ understanding of chemistry. We analyze examples from undergraduate students’ discussions during problem-solving classes through the use of practical epistemology analysis (PEA). Findings suggest that students invoked anthropomorphisms alongside technical relations which together produced more or less chemically appropriate explanations. Also, anthropomorphisms constitute potentially productive points of departure for rendering students’ explanations more chemically appropriate. The implications of this study refer to the need to deal with anthropomorphisms explicitly and repeatedly as well as to encourage explicit connections between different parts of the explanation - teleological as well as causal.
|
|
| 25. |
- A. Manneh, Ilana, 1970-, et al.
(författare)
-
Tutor-student interaction in undergraduate chemistry : a case of learning to make relevant distinctions of molecular structures for determining oxidation states of atoms
- 2018
-
Ingår i: International Journal of Science Education. - : Informa UK Limited. - 0950-0693 .- 1464-5289. ; 40:16, s. 2023-2043
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, we explore the issues and challenges involved in supporting students’ learning to discern relevant and critical aspects of determining oxidation states of atoms in complex molecules. We present a detailed case of an interaction between three students and a tutor during a problem-solving class, using the analytical tool of practical epistemology analysis (PEA). The results show that the ability to make relevant distinctions between the different parts of a molecule for solving the problem, even with the guidance of the tutor, seemed to be challenging for students. These shifts were connected to both purposes that were specific for solving the problem at hand, and additional purposes for general learning of the subject matter, in this case how to assign oxidation states in molecules. The students sometimes could not follow the additional purposes introduced by the tutor, which made the related distinctions more confusing. Our results indicate that in order to provide adequate support and guidance for students the tutor needs to consider how to sequence, move between, and productively connect the different purposes introduced in a tutor-student interaction. One way of doing that is by first pursuing the purposes for solving the problem and then successively introduce additional, more general purposes for developing students’ learning of the subject matter studied. Further recommendations drawn from this study are discussed as well.
|
|
| 26. |
|
|
| 27. |
- A. Mouris, Boules, et al.
(författare)
-
Multi-tone Signal Optimization for Wireless Power Transfer in the Presence of Wireless Communication Links
- 2020
-
Ingår i: IEEE Transactions on Wireless Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 1536-1276 .- 1558-2248. ; 19:5, s. 3575-3590
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, we study optimization of multi-tone signals for wireless power transfer (WPT) systems. We investigate different non-linear energy harvesting models. Two of them are adopted to optimize the multi-tone signal according to the channel state information available at the transmitter. We show that a second-order polynomial curve-fitting model can be utilized to optimize the multi-tone signal for any RF energy harvester design. We consider both single-antenna and multi-antenna WPT systems. In-band co-existing communication links are also considered in this work by imposing a constraint on the received power at the nearby information receiver to prevent its RF front end from saturation. We emphasize the importance of imposing such constraint by explaining how inter-modulation products, due to saturation, can cause high interference at the information receiver in the case of multi-tone signals. The multi-tone optimization problem is formulated as a non-convex linearly constrained quadratic program. Two globally optimal solution approaches using mixed-integer linear programming and finite branch-and-bound techniques are proposed to solve the problem. The achieved improvement resulting from applying both solution methods to the multi-tone optimization problem is highlighted through simulations and comparisons with other solutions existing in the literature.
|
|
| 28. |
- A. Nojima,, et al.
(författare)
-
Calculational aspects of electron-phonon coupling at surfaces
- 2008
-
Ingår i: J. Phys: Condens. Matter. - : IOP Publishing. - 1361-648X .- 0953-8984. ; 20
-
Tidskriftsartikel (refereegranskat)abstract
- We study the validity of two frequently used approximations in calculations of electron–phonon coupling at surfaces. The rigid-ion approximation is a standard approximation used for the bulk metals. On the basis of density functional theory calculations, we find that for Be this approximation is as valid for surface atoms as for bulk atoms. In addition, the slab method for calculations of a phonon induced surface state lifetime is examined. The convergence of the electron–phonon matrix element with respect to the thickness of the slab is studied for several systems. When the number of slab layers is increased, the net effect of decreasing overlap and increasing number of final states depends strongly on the decay length of the surface state wavefunction and the band structure.
|
|
| 29. |
- A. Nojima,, et al.
(författare)
-
Model Eliashberg function for surface states
- 2008
-
Ingår i: Applied Surface Science. ; 254:23
-
Tidskriftsartikel (refereegranskat)abstract
- We present a simplified procedure for the analysis of the phonon-induced lifetimes of surface states. The model includes information about the electron and phonon structure and is thus more reliable than procedures based on phonon Debye models. We apply the model to calculate the lifetime broadening of Cu(1 1 1) and Al(0 0 1) surface states. The obtained Eliashberg functions and lifetimes are in reasonable agreement with previous detailed studies.
|
|
| 30. |
- A.O., Tillmar, et al.
(författare)
-
Using X-chromosomal markers in relationship testing: Calculation of likelihood ratios taking both linkage and linkage disequilibrium into account
- 2011
-
Ingår i: Forensic Science International: Genetics. - : Elsevier BV. - 1872-4973 .- 1878-0326. ; 5:5, s. 506-511
-
Tidskriftsartikel (refereegranskat)abstract
- X-chromosomal markers in forensic genetics have become more widely used during recent years, particularly for relationship testing. Linkage and linkage disequilibrium (LD) must typically be accounted for when using close X-chromosomal markers. Thus, when producing the weight-of-evidence, given by a DNA-analysis with markers that are linked, the normally used product rule is invalid. Here we present an implementation of an efficient model for calculating likelihood ratios (LRs) with markers on the X-chromosome which are linked and in LD. Furthermore, the model was applied on several cases based on data from the eight X-chromosomal loci included in the Mentype® Argus X-8 (Biotype). Using a simulation approach we showed that the use of X-chromosome data can offer valuable information for choosing between the alternatives in each of the cases we studied, and that the LR can be high in several cases. We demonstrated that when linkage and LD were disregarded, as opposed to taken into account, the difference in calculated LRs could be considerable. When these differences were large, the estimated haplotype frequencies often had a strong impact and we present a method to estimate haplotype frequencies. Our conclusion is that linkage and LD should be accounted for when using the tested set of markers, and the used model is an efficient way of doing so.
|
|
| 31. |
|
|
| 32. |
- A.S.M. Monjurul, Hasan, et al.
(författare)
-
Biogas potential from municipal and agricultural residual biomass for power generation in Hazaribagh, Bangladesh : A strategy to improve the energy system
- 2019
-
Ingår i: Renewable Energy Focus. - : Elsevier BV. - 1755-0084. ; 29:June 2019, s. 14-23
-
Tidskriftsartikel (refereegranskat)abstract
- Energy is considered as one of the significant benchmarks towards sustainable growth. Due to the recenteconomic growth, energy demand is increasing day by day in Bangladesh. The power generation mainlyrelies on fossil fuels though there are plans to increase the renewable energy share by the concernstakeholders. Considering the global warming, energy generation from renewable sources is consideredas a sustainable way to mitigate the anthropogenic emission. This study, therefore, addresses thepotentiality of biogas production from municipal waste and agricultural residues in a city territory ofDhaka namely Hazaribagh. The potential sources include wastes from two markets, six slaughterhouses,domestic wastes, one poultry farm and three croplands. The calculations made in this study to estimatethe amount of biogas and electricity from the described sources are done in a simple way, just to illustratethe potential. This study suggests that there is a good potentiality of biogas production and electricitygeneration from municipal wastes and agricultural residues of Hazaribagh. Moreover, this study alsomentions the significant actors like government, future owners, people and so on that are needed to beincorporated to implement biogas solution in a city territory.
|
|
| 33. |
- A:sson Utas, Jan, 1946-
(författare)
-
Ag, bräder och flis
- 1984
-
Ingår i: Kulturminnesvård. - Stockholm : Riksantikvarieämbetet. - 0346-9077. ; :4, s. 12-15
-
Tidskriftsartikel (populärvet., debatt m.m.)
|
|
| 34. |
- A. Strumpfer, Johan, et al.
(författare)
-
Stretching of Twitchin Kinase
- 2012
-
Ingår i: Biophysical Journal. - St. Louis, MO, United States : Cell Press. - 0006-3495 .- 1542-0086. ; 102:3 Supplement 1, s. 361a-362a
-
Tidskriftsartikel (refereegranskat)abstract
- The giant proteins from the titin family, that form cytoskeletal filaments, have emerged as key mechanotransducers in the sarcomere. These proteins contain a conserved kinase region, which is auto-inhibited by a C-terminal tail domain. The inhibitory tail domain occludes the active sites of the kinases, thus preventing ATP from binding. It was proposed that through application of a force, such as that arising during muscle contraction, the inhibitory tail becomes detached, lifting inhibition. The force-sensing ability of titin kinase was demonstrated in AFM experiments and simulations [Puchner, et al., 2008, PNAS:105, 13385], which showed indeed that mechanical forces can remove the autoinhibitory tail of titin kinase. We report here steered molecular dynamics simulations (SMD) of the very recently resolved crystal structure of twitchin kinase, containing the kinase region and flanking fibronectin and immuniglobulin domains, that show a variant mechanism. Despite the significant structural and sequence similarity to titin kinase, the autoinhibitory tail of twitchin kinase remains in place upon stretching, while the N-terminal lobe of the kinase unfolds. The SMD simulations also show that the detachment and stretching of the linker between fibronectin and kinase regions, and the partial extension of the autoinhibitory tail, are the primary force-response. We postulate that this stretched state, where all structural elements are still intact, may represent the physiologically active state.
|
|
| 35. |
- A, Teschendorff, et al.
(författare)
-
The dynamics of DNA methylation covariation patterns in carcinogenesis
- 2014
-
Ingår i: PLoS Computational Biology. - : Public Library of Science (PLoS). - 1553-734X .- 1553-7358. ; 10:7
-
Tidskriftsartikel (refereegranskat)abstract
- Recently it has been observed that cancer tissue is characterised by an increased variability in DNA methylation patterns. However, how the correlative patterns in genome-wide DNA methylation change during the carcinogenic progress has not yet been explored. Here we study genome-wide inter-CpG correlations in DNA methylation, in addition to single site variability, during cervical carcinogenesis. We demonstrate how the study of changes in DNA methylation covariation patterns across normal, intra-epithelial neoplasia and invasive cancer allows the identification of CpG sites that indicate the risk of neoplastic transformation in stages prior to neoplasia. Importantly, we show that the covariation in DNA methylation at these risk CpG loci is maximal immediately prior to the onset of cancer, supporting the view that high epigenetic diversity in normal cells increases the risk of cancer. Consistent with this, we observe that invasive cancers exhibit increased covariation in DNA methylation at the risk CpG sites relative to normal tissue, but lower levels relative to pre-cancerous lesions. We further show that the identified risk CpG sites undergo preferential DNA methylation changes in relation to human papilloma virus infection and age. Results are validated in independent data including prospectively collected samples prior to neoplastic transformation. Our data are consistent with a phase transition model of carcinogenesis, in which epigenetic diversity is maximal prior to the onset of cancer. The model and algorithm proposed here may allow, in future, network biomarkers predicting the risk of neoplastic transformation to be identified.
|
|
| 36. |
- A.V., Fidalgo, et al.
(författare)
-
Adapting remote labs to learning scenarios : Case studies using VISIR and remotElectLab
- 2014
-
Ingår i: Revista Iberoamericana de Tecnologias del Aprendizaje. - : Education Society of IEEE (Spanish Chapter). - 1932-8540. ; 9:1, s. 33-39
-
Tidskriftsartikel (refereegranskat)abstract
- Remote laboratories are an emergent technological and pedagogical tool at all education levels, and their widespread use is an important part of their own improvement and evolution. This paper describes several issues encountered on laboratorial classes, on higher education courses, when using remote laboratories based on PXI systems, either using the VISIR system or an alternate in-house solution. Three main issues are presented and explained, all reported by teachers, that gave support to students' use of remote laboratories. The first issue deals with the need to allow students to select the actual place where an ammeter is to be inserted on electric circuits, even incorrectly, therefore emulating real-world difficulties. The second one deals with problems with timing when several measurements are required at short intervals, as in the discharge cycle of a capacitor. In addition, the last issue deals with the use of a multimeter in dc mode when reading ac values, a use that collides with the lab settings. All scenarios are presented and discussed, including the solution found for each case. The conclusion derived from the described work is that the remote laboratories area is an expanding field, where practical use leads to improvement and evolution of the available solutions, requiring a strict cooperation and information-sharing between all actors, i.e., developers, teachers, and students.
|
|
| 37. |
|
|
| 38. |
-
A wide-band RF front-end for multiband multistandard high-linearity low-IF wireless receivers
- 2002
-
Ingår i: IEEE Journal of Solid-State Circuits. - 0018-9200 .- 1558-173X. ; 37:9, s. 1162-1168
-
Tidskriftsartikel (refereegranskat)abstract
- A wide-band radio-frequency (RF) front-end is designed with a balanced combined low-noise amplifier and a switching mixer (a low-noise converter) in RF Si-bipolar process with an f(T) of 25 GHz. The circuit achieves 20-dB conversion gain, higher than -4.5-dBm RF-to-IF IIP3 (+15.5-dBm OIP3) and less than 3.8-dB double-side-band noise figure in 900-MHz (e.g., GSM) and 1.9-GHz (e.g., WCDMA) frequency bands. The -1-dB compression point is -20 dBm at 13-mA dc current consumption from a single 5-V supply. The local-oscillator leakage to the input is less than -56 dBm in the 900-MHz band and less than -63 dBm in the 1.9-GHz band. The -3-dB bandwidth of the amplifier is larger than 3 GHz and a wide-band matching at the input with - 10 to -41-dB S-11 is achieved in the frequency bands of interest by applying a dual-loop wide-band active feedback. The die area is 0.69 x 0.9 mm(2). The circuit is suitable for area-efficient multiband multistandard low-IF receivers.
|
|
| 39. |
-
A wideband frequency selective surface reflector for 4G/X-Band/Ku-Band
- 2018
-
Ingår i: Progress In Electromagnetics Research C. - : Electromagnetics Academy. - 1937-8718. ; 81, s. 151-159
-
Tidskriftsartikel (refereegranskat)abstract
- A Frequency Selective Surface (FSS) reflector with wideband response for 4G/X-band/Ku-band is proposed. The wideband FSS reflector consists of cascaded dual-layer patch FSS which is etched on separate layers of FR4 substrate. The targeted frequency range is 5–16 GHz. A wide stopband of 10.4 GHz (100% percent bandwidth) is obtained with two layers in cascade. The Equivalent Circuit (EC) method is used to approximate the simulated results. An extensive parametric study is also carried out to understand the effect of various combinations of FSS layers and their disposition. A panel of final FSS is fabricated where measured and simulated results agree well.
|
|
| 40. |
|
|
| 41. |
|
|
| 42. |
|
|
| 43. |
|
|
| 44. |
- Aabel, EW, et al.
(författare)
-
Ventricular arrhythmias in arrhythmic mitral valve syndrome-a prospective continuous long-term cardiac monitoring study
- 2023
-
Ingår i: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. - : Oxford University Press (OUP). - 1532-2092. ; 25:2, s. 506-516
-
Tidskriftsartikel (refereegranskat)abstract
- AimsArrhythmic mitral valve syndrome is linked to life-threatening ventricular arrhythmias. The incidence, morphology and methods for risk stratification are not well known. This prospective study aimed to describe the incidence and the morphology of ventricular arrhythmia and propose risk stratification in patients with arrhythmic mitral valve syndrome.MethodsArrhythmic mitral valve syndrome patients were monitored for ventricular tachyarrhythmias by implantable loop recorders (ILR) and secondary preventive implantable cardioverter-defibrillators (ICD). Severe ventricular arrhythmias included ventricular fibrillation, appropriate or aborted ICD therapy, sustained ventricular tachycardia and non-sustained ventricular tachycardia with symptoms of hemodynamic instability.ResultsDuring 3.1 years of follow-up, severe ventricular arrhythmia was recorded in seven (12%) of 60 patients implanted with ILR [first event incidence rate 4% per person-year, 95% confidence interval (CI) 2–9] and in four (20%) of 20 patients with ICD (re-event incidence rate 8% per person-year, 95% CI 3–21). In the ILR group, severe ventricular arrhythmia was associated with frequent premature ventricular complexes, more non-sustained ventricular tachycardias, greater left ventricular diameter and greater posterolateral mitral annular disjunction distance (all P < 0.02).ConclusionsThe yearly incidence of ventricular arrhythmia was high in arrhythmic mitral valve syndrome patients without previous severe arrhythmias using continuous heart rhythm monitoring. The incidence was even higher in patients with secondary preventive ICD. Frequent premature ventricular complexes, non-sustained ventricular tachycardias, greater left ventricular diameter and greater posterolateral mitral annular disjunction distance were predictors of first severe arrhythmic event.
|
|
| 45. |
- Aabel, Lise, et al.
(författare)
-
A TDD Distributed MIMO Testbed Using a 1-bit Radio-Over-Fiber Fronthaul Architecture
- 2024
-
Ingår i: IEEE Transactions on Microwave Theory and Techniques. - 0018-9480 .- 1557-9670. ; In Press
-
Tidskriftsartikel (refereegranskat)abstract
- We present the uplink and downlink of a time-division duplex distributed multiple-input multiple-output (D-MIMO) testbed, based on a 1-bit radio-over-fiber architecture, which is low cost and scalable. The proposed architecture involves a central unit (CU) that is equipped with 1-bit digital-to-analog and analog-to-digital converters, operating at 10 GS/s. The CU is connected to multiple single-antenna remote radio heads (RRHs) via optical fibers, over which a binary radio frequency (RF) waveform is transmitted. In the uplink, a binary RF waveform is generated at the RRHs by a comparator, whose inputs are the received RF signal and a suitably designed dither signal. In the downlink, a binary RF waveform is generated at the CU via bandpass sigma-delta modulation. Our measurement results show that low error-vector magnitude (EVM) can be achieved in both the uplink and the downlink, despite 1-bit sampling at the CU. Specifically, for point-to-point over-cable transmission between a single user equipment (UE) and a CU equipped with a single RRH, we report, for a 10-MBd signal using single-carrier (SC) 16 quadratic-amplitude modulation (QAM) modulation, an EVM of 3.3% in the downlink, and of 4.5% in the uplink. We then consider a CU connected to three RRHs serving over the air two UEs, and show that, after over-the-air reciprocity calibration, a downlink zero-forcing precoder designed on the basis of uplink channel estimates at the CU achieves an EVM of 6.4% and 10.9% at UE 1 and UE 2, respectively. Finally, we investigate the ability of the proposed architecture to support orthogonal frequency-division multiplexing (OFDM) waveforms, and its robustness against both in-band and out-of-band interference.
|
|
| 46. |
- Aabel, Peder, et al.
(författare)
-
Transcription and microRNA Profiling of Cultured Human Tympanic Membrane Epidermal Keratinocytes
- 2018
-
Ingår i: Journal of the Association for Research in Otolaryngology. - : SPRINGER. - 1525-3961 .- 1438-7573. ; 19:3, s. 243-260
-
Tidskriftsartikel (refereegranskat)abstract
- The human tympanic membrane (TM) has a thin outer epidermal layer which plays an important role in TM homeostasis and ear health. The specialised cells of the TM epidermis have a different physiology compared to normal skin epidermal keratinocytes, displaying a dynamic and constitutive migration that maintains a clear TM surface and assists in regeneration. Here, we characterise and compare molecular phenotypes in keratinocyte cultures from TM and normal skin. TM keratinocytes were isolated by enzymatic digestion and cultured in vitro. We compared global mRNA and microRNA expression of the cultured cells with that of human epidermal keratinocyte cultures. Genes with either relatively higher or lower expression were analysed further using the biostatistical tools g:Profiler and Ingenuity Pathway Analysis. Approximately 500 genes were found differentially expressed. Gene ontology enrichment and Ingenuity analyses identified cellular migration and closely related biological processes to be the most significant functions of the genes highly expressed in the TM keratinocytes. The genes of low expression showed a marked difference in homeobox (HOX) genes of clusters A and C, giving the TM keratinocytes a strikingly low HOX gene expression profile. An in vitro scratch wound assay showed a more individualised cell movement in cells from the tympanic membrane than normal epidermal keratinocytes. We identified 10 microRNAs with differential expression, several of which can also be linked to regulation of cell migration and expression of HOX genes. Our data provides clues to understanding the specific physiological properties of TM keratinocytes, including candidate genes for constitutive migration, and may thus help focus further research.
|
|
| 47. |
- Aabenhus, Rune, et al.
(författare)
-
First attempt to produce experimental Campylobacter concisus infection in mice
- 2008
-
Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327. ; 14:45, s. 6954-6959
-
Tidskriftsartikel (refereegranskat)abstract
- AIM: To infect mice with atypical Campylobacter concisus (C concisus) for the first time. METHODS: Three separate experiments were conducted in order to screen the ability of five clinical C concisus isolates of intestinal origin and the ATCC 33237 type strain of oral origin to colonize and produce infection in immunocompetent BALB/cA mice. The majority of the BALB/cA mice were treated with cyclophosphamide prior to C concisus inoculation to suppress immune functions. Inoculation of C concisus was performed by the gastric route. RESULTS: C concisus was isolated from the liver, ileum and jejunum of cyclophosphamide-treated mice in the first experiment. No C concisus strains were isolated in the two subsequent experiments. Mice infected with C concisus showed a significant loss of body weight from day two through to day five of infection but this decreased at the end of the first week. Histopathologicalexamination did not consistently find signs of inflammation in the gut, but occasionally microabscesses were found in the liver of infected animals. CONCLUSION: Transient colonization with C concisus was observed in mice with loss of body weight. Future studies should concentrate on the first few days after inoculation and in other strains of mice. (C) 2008 The WJG Press. All rights reserved.
|
|
| 48. |
- Aabenhus, Rune, et al.
(författare)
-
Lectin Typing of Campylobacter concisus
- 2002
-
Ingår i: Journal of Clinical Microbiology. - 1098-660X. ; 40:2, s. 715-717
-
Tidskriftsartikel (refereegranskat)abstract
- A total of 44 clinical isolates and the type strain of the putative pathogen Campylobacter concisus were grouped based on their reactions with plant lectins. The optimized lectin typing system used C. concisus strains proteolytically pretreated and subsequently typed by using a panel of four lectins. The system grouped all 45 strains into 13 lectin reaction patterns, leaving no strain untypeable due to autoagglutination. Lectin types were both stable and reproducible.
|
|
| 49. |
- Aaberg, Oddveig Reiersdal, et al.
(författare)
-
A human factors intervention in a hospital-evaluating the outcome of a TeamSTEPPS program in a surgical ward
- 2021
-
Ingår i: BMC Health Services Research. - : BioMed Central. - 1472-6963. ; 21:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Patient safety in hospitals is being jeopardized, since too many patients experience adverse events. Most of these adverse events arise from human factors, such as inefficient teamwork and communication failures, and the incidence of adverse events is greatest in the surgical area. Previous research has shown the effect of team training on patient safety culture and on different areas of teamwork. Limited research has investigated teamwork in surgical wards. The aim of this study was to evaluate the professional and organizational outcomes of a team training intervention among healthcare professionals in a surgical ward after 6 and 12 months. Systems Engineering Initiative for Patient Safety 2.0 was used as a conceptual framework for the study. Methods: This study had a pre-post design with measurements at baseline and after 6 and 12 months of intervention. The intervention was conducted in a urology and gastrointestinal surgery ward in Norway, and the study site was selected based on convenience and the leaders' willingness to participate in the project. Survey data from healthcare professionals were used to evaluate the intervention. The organizational outcomes were measured by the unit-based sections of the Hospital Survey of Patient Safety Culture Questionnaire, and professional outcomes were measured by the TeamSTEPPS Teamwork Perceptions Questionnaire and the Collaboration and Satisfaction about Care Decisions in Teams Questionnaire. A paired t-test, a Wilcoxon signed-rank test, a generalized linear mixed model and linear regression analysis were used to analyze the data. Results: After 6 months, improvements were found in organizational outcomes in two patient safety dimensions. After 12 months, improvements were found in both organizational and professional outcomes, and these improvements occurred in three patient safety culture dimensions and in three teamwork dimensions. Furthermore, the results showed that one of the significant improved teamwork dimensions "Mutual Support" was associated with the Patient Safety Grade, after 12 months of intervention. Conclusion: These results demonstrate that the team training program had effect after 12 months of intervention. Future studies with larger sample sizes and stronger study designs are necessary to examine the causal effect of a team training intervention in this context.
|
|
| 50. |
- Aaberg, Oddveig Reiersdal, et al.
(författare)
-
An interprofessional team training intervention with an implementation phase in a surgical ward : A controlled quasi-experimental study
- 2019
-
Ingår i: Journal of Interprofessional Care. - : Taylor & Francis. - 1356-1820 .- 1469-9567. ; , s. 1-10
-
Tidskriftsartikel (refereegranskat)abstract
- Despite a growing awareness of the importance of interprofessional teamwork in relation to patient safety, many hospital units lack effective teamwork. The aim of this study was to explore if an interprofessional teamwork intervention in a surgical ward changed the healthcare personnel's perceptions of patient safety culture, perceptions of teamwork, and attitudes toward teamwork over 12 months. Healthcare personnel from surgical wards at two hospitals participated in a controlled quasi-experimental study. The intervention consisted of six hours of TeamSTEPPS team training and 12 months for the implementation of teamwork tools and strategies. The data collection was conducted among the healthcare personnel in the intervention group and the control group at baseline and at the end of the 12 month study period. The results within the intervention group showed that there were significantly improved scores in three of 12 patient safety culture dimensions and in three of five perceptions of teamwork dimensions after 12 months. When comparing between groups, significant differences were found in three patient safety culture measures in favor of the intervention group. The results of the study suggest that the teamwork intervention had a positive impact on patient safety culture and teamwork in the surgical ward.
|
|
