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- Ahlin, Erik, et al.
(författare)
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Anti-citrullinated peptide antibodies and rheumatoid factor in Sudanese patients with Leishmania donovani infection
- 2011
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Ingår i: REV BRAS REUMATOL. - 0482-5004. ; 51:6, s. 572-586
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The present study evaluated the presence of anti-cyclic citrullinated peptides antibodies (anti-CCP), rheumatoid factor (RF), and circulating immune complexes (CIC) in Sudanese patients infected with the Leishmania donovani parasite. Patients and methods: Sera were collected from Leishmania infected patients (n = 116) and healthy Sudanese (n = 93). Nineteen Sudanese anti-CCP+RA patients were included as positive controls. Levels of CIC and anti-CCP were measured by ELISA. Control plate with cyclic control peptides containing arginine instead of citrulline was used to evaluate citrulline specific reactivity. Results: Among Leishmania-infected patients and anti-CCP+RA patients, most were RF positive (86%), while the frequency of CIC positivity was higher among visceral leishmaniasis (VL) patients (VL 38%; anti-CCP+RA 24%). When anti-CCP reactivity was analysed, 12% of VL patients were found to be positive. The levels of anti-CCP among V L patients correlated well with the CIC levels found (r = 0.65, P < 0.0001). In RA group, no association was found between CIC and anti-CCP. The possibility that anti-CCP positivity was due to cross reactions with CIC was experimentally ruled out. Contrary to what was seen in Sudanese RA sera, the CCP reactivity was not restricted to citrulline but reacted equally well with the arginine control peptide. Conclusion: The finding that CCP reactivity was not restricted to citrulline argues that this is more an effect of extensive inflammation and immune activation than a sign of shared pathogenic characteristics with anti-CCP arthritis. Our findings stress the importance to interpret a positive CCP test carefully when evaluated in non-rheumatic conditions or in areas where such infections predominate.
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| 2. |
- Roos, August K., et al.
(författare)
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Kinetic Inductive Electromechanical Transduction for Nanoscale Force Sensing
- 2023
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Ingår i: Physical Review Applied. - : American Physical Society. - 2331-7019. ; 20:2
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Tidskriftsartikel (refereegranskat)abstract
- We use the principles of cavity optomechanics to design a resonant mechanical force sensor for atomic force microscopy. The sensor is based on a type of electromechanical coupling, dual to traditional capacitive coupling, whereby the motion of a cantilever induces surface strain that causes a change in the kinetic inductance of a superconducting nanowire. The cavity is realized by a compact microwave-plasma mode with an equivalent LC circuit involving the kinetic inductance of the nanowire. The device is fully coplanar and we show how to transform the cavity impedance for optimal coupling to the transmission line and the following amplifier. For the device presented here, we estimate the bare kinetic inductive mechanoelectric coupling (KIMEC) rate g0/2π in the range 3–10 Hz. We demonstrate phase-sensitive detection of cantilever motion using a multifrequency pumping and measurement scheme.
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