| 1. |
- Arroyo-Torres, B., et al.
(author)
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VLTI/AMBER Studies of the Atmospheric Structure and Fundamental Parameters of Red Giant and Supergiant Stars
- 2015
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In: WHY GALAXIES CARE ABOUT AGB STARS III. - : ASTRONOMICAL SOC PACIFIC. - 9781583818794 ; , s. 91-96
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Conference paper (other academic/artistic)abstract
- We present recent near-IR interferometric studies of red giant and super giant stars, which are aimed at obtaining information on the structure of the atmospheric layers and constraining the fundamental parameters of these objects. The observed visibilities of six red supergiants (RSGs), and also of one of the five red giants observed, indicate large extensions of the molecular layers, as previously observed for Mira stars. These extensions are not predicted by hydrostatic PHOENIX model atmospheres, hydrodynamical (RED) simulations of stellar convection, or self-excited pulsation models. All these models based on parameters of RSGs lead to atmospheric structures that are too compact compared to our observations. We discuss how alternative processes might explain the atmospheric extensions for these objects. As the continuum appears to be largely free of contamination by molecular layers, we can estimate reliable Rosseland angular radii for our stars. Together with distances and bolometric fluxes, we estimate the effective temperatures and luminosities of our targets, locate them in the HR diagram, and compare their positions to recent evolutionary tracks.
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| 2. |
- Arroyo-Torres, B., et al.
(author)
-
VLTI/AMBER studies of the atmospheric structure and fundamental parameters of red giant and supergiant stars
- 2015
-
In: Why Galaxies Care about AGB Stars III: A Closer Look in Space and Time. Proceedings of ASP Conference Series. - 9781583818794 ; 497, s. 91-96
-
Conference paper (other academic/artistic)abstract
- We present recent near-IR interferometric studies of red giant and supergiant stars, which are aimed at obtaining information on the structure of the atmospheric layers and at constraining the fundamental parameters of these objects. The observed visibilities of the red supergiants (RSGs) and also of one red giant indicate large extensions of the molecular layers, as those previously observed for Mira stars. These extensions are not predicted by hydrostatic PHOENIX model atmospheres, hydrodynamical (RHD) simulations of stellar convection, or self-excited pulsation models. All these models based on parameters of RSGs lead to atmospheric structures that are too compact compared to our observations. We discuss how alternative processes might explain the atmospheric extensions for these objects. As the continuum appears to be largely free of contamination by molecular layers, we can estimate reliable angular Rosseland radii of our stars. Together with distances and bolometric fluxes, we estimate the effective temperatures and luminosities of our targets, locate them in the HR diagram, and compare their positions to recent evolutionary tracks.
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| 3. |
- Ardura-Fabregat, A., et al.
(author)
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Targeting Neuroinflammation to Treat Alzheimer’s Disease
- 2017
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In: CNS Drugs. - : Springer Science and Business Media LLC. - 1172-7047 .- 1179-1934. ; 31:12, s. 1-26
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Research review (peer-reviewed)abstract
- Over the past few decades, research on Alzheimer’s disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal formation of neurofibrils. Recently, a third disease component, the neuroinflammatory reaction mediated by cerebral innate immune cells, has entered the spotlight, prompted by findings from genetic, pre-clinical, and clinical studies. Various proteins that arise during neurodegeneration, including beta-amyloid, tau, heat shock proteins, and chromogranin, among others, act as danger-associated molecular patterns, that—upon engagement of pattern recognition receptors—induce inflammatory signaling pathways and ultimately lead to the production and release of immune mediators. These may have beneficial effects but ultimately compromise neuronal function and cause cell death. The current review, assembled by participants of the Chiclana Summer School on Neuroinflammation 2016, provides an overview of our current understanding of AD-related immune processes. We describe the principal cellular and molecular players in inflammation as they pertain to AD, examine modifying factors, and discuss potential future therapeutic targets.
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