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1.	Bäck, Marcus, et al. (author) Design, synthesis and SAR of potent statine-based BACE-1 inhibitors : Exploration of P1 phenoxy and benzyloxy residues 2008 In: Bioorganic & Medicinal Chemistry. - : Elsevier BV. - 0968-0896 .- 1464-3391. ; 16:21, s. 9471-9486 Journal article (peer-reviewed)abstract Several BACE-1 inhibitors with low nanomolar level activities, encompassing a statine-based core structure with phenyloxymethyl- and benzyloxymethyl residues in the P1 position, are presented. The novel P1 modi. cation introduced to allow the facile exploration of the S1 binding pocket of BACE-1, delivered highly promising inhibitors.

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Author/Editor: Jansson, Katarina (1); Lindberg, Jimmy (1); Hallberg, Anders (1); Samuelsson, Bertil (1); Kvarnström, Ingemar (1); Nyhlén, Jonas (1); show more...; Bäck, Marcus (1); Borkakoti, Neera (1); Appelgren, Sara (1); Nystrom, Susanne (1); Rosenquist, Asa (1); Rosenquist, Sa (1); show less...

University: Uppsala University (1); Stockholm University (1); Linköping University (1)

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