↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "(WFRF:(Tiensuu Janson Eva)) pers:(Lannfelt Lars) srt2:(2014)"

Search: (WFRF:(Tiensuu Janson Eva)) pers:(Lannfelt Lars) > (2014)

Result 1-1 of 1

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Forsberg, Lars A., et al. (author) Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer 2014 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46:6, s. 624-628 Journal article (peer-reviewed)abstract Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained(1,2). Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells(3,4), but the phenotypic consequences of LOY have been elusive(5-10). From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91, 95% confidence interval (CI) = 1.17-3.13; 637 events) and non-hematological cancer mortality (HR = 3.62, 95% CI = 1.56-8.41; 132 events). LOY affected at least 8.2% of the subjects in this cohort, and median survival times among men with LOY were 5.5 years shorter. Association of LOY with risk of all-cause mortality was validated in an independent cohort (HR = 3.66) in which 20.5% of subjects showed LOY. These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why males are more frequently affected by cancer and suggest that chromosome Y is important in processes beyond sex determination. LOY in blood could become a predictive biomarker of male carcinogenesis.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-1 of 1

Refine your search

Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Lind, Lars (1); Lannfelt, Lars (1); Ingelsson, Erik (1); Tiensuu Janson, Eva (1); Zaghlool, Ammar (1); Dumanski, Jan P (1); show more...; Sandgren, Johanna (1); de Stahl, Teresita D ... (1); Absher, Devin (1); Giedraitis, Vilmanta ... (1); Lindgren, Cecilia M. (1); Morris, Andrew P. (1); Cross, Nicholas C.P. (1); Davies, Hanna (1); Rasi, Chiara (1); Forsberg, Lars A. (1); Score, Joannah (1); Pakalapati, Geeta (1); Malmqvist, Niklas (1); Pasupulati, Saichand (1); show less...

University: Uppsala University (1); Karolinska Institutet (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2014 (1)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view