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Search: (WFRF:(Wolfgang Andreas 1977)) srt2:(2005-2009) > (2006)

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  • Robinson, Yohan, 1977, et al. (author)
  • Erythropoiesis in multiply injured patients.
  • 2006
  • In: The Journal of trauma. - : Ovid Technologies (Wolters Kluwer Health). - 0022-5282 .- 1529-8809. ; 61:5, s. 1285-91
  • Research review (peer-reviewed)abstract
    • Posttraumatic anemia in multiply injured patients is caused by hemorrhage, reduced red blood cell survival, and impaired erythropoiesis. Trauma-induced hyperinflammation causes impaired bone-marrow function by means of blunted erythropoietin (EPO) response, reduced iron availability, suppression and egress of erythroid progenitor cells. To treat posttraumatic anemia in severely injured patients, symptomatic therapy by blood transfusion is not sufficient. Furthermore, EPO, iron, and the use of red cell substitutes should be considered. The posttraumatic systemic inflammatory response syndrome (SIRS) induces posttraumatic anemia. Thus, a worsening of SIRS by a "second-hit" through blood transfusion ought to be avoided.
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Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
Robinson, Yohan, 197 ... (1)
Hostmann, Arwed (1)
Oberholzer, Andreas (1)
Ertel, Wolfgang (1)
Matenov, Alexander (1)
University
University of Gothenburg (1)
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2006 (1)Undo refine

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