| 1. |
- Forsberg, Maria, 1973-, et al.
(författare)
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Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils
- 2003
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Ingår i: Journal of Leukocyte Biology. - : Oxford University Press (OUP). - 0741-5400 .- 1938-3673. ; 74:4, s. 611-619
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Tidskriftsartikel (refereegranskat)abstract
- Phagocytosis is a complex process engaging a concerted action of signal-transduction cascades that leads to ingestion, subsequent phagolysosome fusion, and oxidative activation. We have previously shown that in human neutrophils, C3bi-mediated phagocytosis elicits a significant oxidative response, suggesting that activation of the small GTPase Rac is involved in this process. This is contradictory to macrophages, where only Fc receptor for immunoglobulin G (FcγR)-mediated activation is Rac-dependent. The present study shows that engagement of the complement receptor 3 (CR3) and FcγR and CR3- and FcγR-mediated phagocytosis activates Rac, as well as Cdc42. Furthermore, following receptor-engagement of the CR3 or FcγRs, a downstream target of these small GTPases, p21-activated kinase, becomes phosphorylated, and Rac2 is translocated to the membrane fraction. Using the methyltransferase inhibitors N-acetyl-S-farnesyl-L-cysteine and N-acetyl-S-geranylgeranyl-L-cysteine, we found that the phagocytic uptake of bacteria was not Rac2- or Cdc42-dependent, whereas the oxidative activation was decreased. In conclusion, our results indicate that in neutrophils, Rac2 and Cdc42 are involved in FcR- and CR3-induced activation and for properly functioning signal transduction involved in the generation of oxygen radicals.
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| 2. |
- Karlsson, Martin, 1978, et al.
(författare)
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Prophylactic Fibrinogen Infusion in Cardiac Surgery Patients: Effects on Biomarkers of Coagulation, Fibrinolysis, and Platelet Function.
- 2011
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Ingår i: Clinical and applied thrombosis/hemostasis. - : SAGE Publications. - 1938-2723 .- 1076-0296. ; 17:4, s. 393-404
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Tidskriftsartikel (refereegranskat)abstract
- Objective: We have recently reported that prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass grafting (CABG) surgery. Because fibrinogen for the first time was administered to patients without hereditary fibrinogen deficiency or ongoing bleeding, a detailed analysis of the effects of fibrinogen concentrate on biomarkers of coagulation, fibrinolysis, and platelet function was performed. Methods: Twenty CABG patients with preoperative plasma fibrinogen levels <3.8 g/L were included in a prospective study. Patients were randomized to preoperative infusion of 2 g fibrinogen concentrate (fibrinogen group) or no infusion (control group). Activated partial thromboplastin time (aPTT), prothrombin time, activated clotting time, and plasma concentrations of fibrinogen, antithrombin, thrombin-antithrombin complex, prothrombin fragment 1.2, and d-dimer, thromboelastometry, platelet count, and platelet aggregometry were analyzed before and 15 minutes after infusion, and 2 and 24 hours after surgery. Results: Fifteen minutes after infusion of fibrinogen concentrate, fibrinogen plasma levels increased by 0.6 +/- 0.2 g/L (P < .001 between groups), and induced minimal changes in aPTT and plasma levels of antithrombin, while remaining variables remained unchanged. After surgery, fibrinogen levels no longer differed between groups. d-dimer was significantly higher after surgery in the fibrinogen group (P = .03), while none of the other markers were statistically different between groups. Conclusions: Infusion of 2 g fibrinogen to cardiac surgery patients, without hereditary or acquired fibrinogen deficiency or ongoing bleeding, results in no or minimal changes in biomarkers reflecting coagulation and platelet function. An increased release of fibrin degradation products was detected after surgery in fibrinogen-treated patients.
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| 3. |
- Beckerman, Carina, 1956-
(författare)
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Transforming and Computerizing Professional Artifacts : An Underestimated Opportunity for Learning
- 2010
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Ingår i: International Journal of Healthcare Delivery Reform Initiative. - Philadelphia, US : IGI Publishing. - 1938-0216 .- 1938-0224. ; 2:3, s. -10
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Tidskriftsartikel (refereegranskat)abstract
- Improving the artifacts a knowledge worker uses and how he or she exercises his or her knowledge is a desire that is part of being professional, especially since modern man are supposed to live in a knowledge society. In the knowledge society there is a continuous structuring and re-structuring, construction and re-construction and learning and re-learning going on due to implementing new information and communication technology. But many of these projects fail in spite of management spending huge amounts of money on them. This paper focuses on and wants to create an awareness of how an artefact such as a new knowledge management system becomes a driving force behind expanding the knowledge of an anesthesist and has implications for continuous learning among a group of employees at the anesthesia and intensive care unit. In addition to this, implementing new technology is an underestimated opportunity for learning. This paper suggests that a significant educational effort is taking place in society channelled through many these IT-projects, even when they fail.
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| 4. |
- Aramo-Immonen, Heli, 1964-, et al.
(författare)
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Multicultural Software Development : The Productivity Perspective
- 2011
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Ingår i: International Journal of Information Technology Project Management. - : IGI Global. - 1938-0232 .- 1938-0240. ; 2:1, s. 19-36
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Tidskriftsartikel (refereegranskat)abstract
- Productivity management is a challenge for software engineering companies and, in this regard, there is a current trend toward globalization. Via acquisitions and mergers, business has become international and employs different national cultures. Therefore, the focus of this article is on the understanding of cultural differences affecting productivity in globalized software production. The relation between productivity and non coding activities in software development projects has not been proven. Software development is expert work, typically made in closely collaborating local teams and global distribution of expert work increases the degree of difficulty. In this paper, the authors analyze multicultural ICT companies from their productivity perspective through the lens of cultural differences. The purpose of this study is to report findings based on general cultural studies and reported experiences that seem to affect productivity in the software industry. Some company cases are also described and analyzed.
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| 5. |
- Carlson, Annika, et al.
(författare)
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Kinetic parameters in anion-exchange membrane fuel cells
- 2019
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Ingår i: ECS Transactions. - : Electrochemical Society Inc.. - 1938-6737 .- 1938-5862. - 9781607685395 ; , s. 649-659
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Konferensbidrag (refereegranskat)abstract
- Understanding limitations in an operating AEMFC is essential to .enhance the technology. Here the electrode processes are studied experimentally as well as by two physics-based models taking the porosity of the electrodes into account. The aim is to use the models to determine kinetic parameters specific for in-situ operation. The models can also be used to explain the experimental .behavior. From the impedance model of a symmetric H2/H2 cell it is shown that the hydrogen oxidation reaction (HOR) proceeds through the Tafel-Volmer reaction pathway, with the hydrogen adsorption as the slower reaction step. Based on the HOR model a •steady-state model of an O2/H2 cell is used to evaluate data from 14 experimental I-V curves, obtained for different gas partial pressures and catalyst loadings, in order to study the effects of the oxygen reduction reaction and overall cell limitations. The results show that the oxygen reduction reaction kinetics limit the cell performance for low current densities. However, at higher currents the uneven current distribution and locally low hydrogen adsorption at the anode increasingly affect the overall performance. Uneven current distribution is also observed at the cathode and likely caused by insufficient effective ionomer conductivity.
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| 6. |
- Chen, J. T., et al.
(författare)
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Carbon-doped GaN on SiC materials for low-memory-effect devices
- 2016
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Ingår i: ECS Transactions. - : The Electrochemical Society. - 1938-5862 .- 1938-6737. - 9781607685395 ; 75:12, s. 61-65, s. 61-65
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Konferensbidrag (refereegranskat)abstract
- AlGaN/GaN on SiC HEMT structures suitable for high power, high frequency applications are demonstrated. The material manifests record breaking thermal management and electron mobility. Moreover, thanks to the fact that the buffer layer is doped with carbon, the memory effect of processed devices is very low making system design and manufacturing significantly easier and less expensive.
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| 7. |
- Habib, K., et al.
(författare)
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Resistance values of aluminum oxide film in situ during anodization of aluminum by fabry-pérot interferometry
- 2017
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Ingår i: ECS Transactions. - : Electrochemical Society Inc.. - 1938-6737 .- 1938-5862. - 9781607685395 ; , s. 1221-1229
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Konferensbidrag (refereegranskat)abstract
- A combination of Fabry-Pérot interferometry and the DC electrochemical method have been used for the first time, in situ, to measure the resistance of aluminum oxide films in 2% sulfuric acid solution. Values of the corresponding resistance of the obtained Al2O3 film thickness were determined during anodization of aluminum (Al) in 2% H2SO4. The obtained resistance values were verified by electrochemical impedance spectroscopy (EIS) and holographic interferometry. The corresponding resistance (2.4 x109 Ohms) to the final thickness of the aluminum oxide film was found in an agreement with the resistance value that was measured by holographic interferometry, 2.54x109 Ohms, in 2% H2SO4. On the contrary, the corresponding resistance (2.4 x109 Ohms) to the final thickness of the aluminum oxide film was found twice the value of the resistance that was measured by the electrochemical impedance spectroscopy (EIS), 1.25x109 Ohms, in 2% H2SO4.
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| 8. |
- Hu, Lan, et al.
(författare)
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Electrode kinetics of the Ni porous electrode for hydrogen production in the molten carbonate electrolysis cell (MCEC)
- 2015
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Ingår i: ECS Transactions. - : The Electrochemical Society. - 1938-5862 .- 1938-6737. - 9781607685395 ; , s. 93-98
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Konferensbidrag (refereegranskat)abstract
- The hydrogen evolution reaction in molten carbonate salts is an important process in the development of the molten carbonate electrolysis cell (MCEC). In the present study the kinetics of hydrogen production in the Ni porous electrode in a MCEC is investigated. The general procedure is to determine the reaction orders of hydrogen, carbon dioxide and water. For this purpose steady-state polarization data were recorded under different gas compositions and temperatures. The exchange current densities were calculated from the slopes of the polarization curves at low overpotential. On the basis of that, the partial pressure dependencies of hydrogen, carbon dioxide and water could be determined in the electrolysis operation.
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| 9. |
- Marcusson, Leif, 1954-, et al.
(författare)
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Applying a core competence model on Swedish job advertisements for IT project managers
- 2015
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Ingår i: International Journal of Information Technology Project Management. - : IGI Global. - 1938-0232 .- 1938-0240. ; 6:2, s. 1-17
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Tidskriftsartikel (refereegranskat)abstract
- Recruitments of IT project managers are costly and time-consuming, which makes it important to handle them effectively. IT project managers’ key function in IT projects conveys that the prerequisites in such job ads become extensive and hard to satisfy because of overloaded descriptions. The organization’s core competence (henceforth CC) requirements need to be decisive and explicitly expressed. Hence, each recruitment process should involve the defining of what the CC qualifications are. Advertisements were collected (2010-2013) and a CC lens was tested for assessment of CC criteria in order to get an indication of its value. The study’s practical implication is an added understanding of the importance to discern what core competence/-s a specific project requires and furthermore to match those with the job requirements during the recruitment process. The implication for research is an inspiration for further development of methods for determining core competence criteria for recruiting IT-project managers.
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| 10. |
- Marcusson, Leif, 1954-, et al.
(författare)
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Swedish IT project managers’ personality traits mirrored in the Big five
- 2016
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Ingår i: International Journal of Information Technology Project Management. - : IGI Global. - 1938-0232 .- 1938-0240. ; 7:3, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- Project success, which is critical to achieve, requires a competent project manager. Could anybody become a skilled project manager, or what does it take? One factor that is considered to influence the opportunities of succeeding is individuals’ personality traits. Which ones would be suitable for Swedish IT project managers then? Could these be mirrored in the perspective of the Big five categories? This research was carried out by collecting and analyzing job advertisements (henceforth ads.) once a year (2010-2013), in total 325 ads. The findings indicate that the three most requested personality traits for a Swedish IT project manager are driven, communicative and structured. Mirrored in the Big five dimensions the most requested traits from the study fell into the categories conscientiousness and extraversion. The practical implication is improved ads. by using the Big five categories; research implications are foremost yet another perspective of IT project managers’ personality traits.
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