| 1. |
- Hollengreen, Laura, et al.
(författare)
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Design at the Border : Liminality, the Virtual, and Interior Transformation from Antiquity to Mixed Reality
- 2022
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Ingår i: Virtual Interiorities. - Pittsburgh, PA : ETC Press. - 9781387515547 - 9781387492497 ; , s. 137-171
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Bokkapitel (refereegranskat)abstract
- This chapter introduces elements of “liminal design,” deuned across his- torical and contemporary works as design that provides the “participant,” “passer-by,” or “pilgrim” with the potential of transformational experi- ence via the liminal or betwixt/between. Drawing connections between theory, history, and practice in mixed realities and liminality, we are pur- suing an emergent typology of liminal design abstracted from analysis of a trans-historical group of works that illuminates aspects of the ancient and medieval heritage of contemporary mixed reality (MR) technologies. This chapter is part of a larger ongoing project comparing examples of liminal design from the Middle Ages and contemporary mixed reality, which we begin here with three examples selected for the ways they res- onate across many characteristics with the concept of the border. The works to be discussed in this text include Qal’at Sim’an, the martyrium and cult site of Saint Simeon the Stylite, and associated objects (5th cen- tury, Syria); Border Memorial: Frontera de los Muertos (2012, John Craig Freeman); and Abraham Lincoln: War Veterans Project (2012, Krzysztof Wodiczko).
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| 2. |
- Shteinfer-Kuzmine, Anna, et al.
(författare)
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A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS
- 2019
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Ingår i: Frontiers in Cellular Neuroscience. - : FRONTIERS MEDIA SA. - 1662-5102. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Mutations in superoxide dismutase (SOD1) are the second most common cause of familial amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease caused by the death of motor neurons in the brain and spinal cord. SOD1 neurotoxicity has been attributed to aberrant accumulation of misfolded SOD1, which in its soluble form binds to intracellular organelles, such as mitochondria and ER, disrupting their functions. Here, we demonstrate that mutant SOD1 binds specifically to the N-terminal domain of the voltage-dependent anion channel (VDAC1), an outer mitochondrial membrane protein controlling cell energy, metabolic and survival pathways. Mutant SOD1(G93A) and SOD1(G85R), but not wild type SOD1, directly interact with VDAC1 and reduce its channel conductance. No such interaction with N-terminal-truncated VDAC1 occurs. Moreover, a VDAC1-derived N-terminal peptide inhibited mutant SOD1-induced toxicity. Incubation of motor neuron-like NSC-34 cells expressing mutant SOD1 or mouse embryonic stem cell-derived motor neurons with different VDAC1 N-terminal peptides resulted in enhanced cell survival. Taken together, our results establish a direct link between mutant SOD1 toxicity and the VDAC1 N-terminal domain and suggest that VDAC1 N-terminal peptides targeting mutant SOD1 provide potential new therapeutic strategies for ALS.
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| 3. |
- Zelli, Fariborz
(författare)
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New Earth Politics: Essays from the Anthropocene
- 2017
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Ingår i: Global Environmental Politics. - 1526-3800. ; 17:1, s. 129-129
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Recension (refereegranskat)abstract
- Review of 'New Earth Politics: Essays from the Anthropocene', ed. by Simon Nicholson and Sikina Jinnah
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| 4. |
- Mauritzson-Sandberg, Eva
(författare)
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Barns psykologiska reaktioner på användning av andningsskydd
- 1993
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Research on psychological reactions on wearing respiratory protective devices (RPDs) has been initiated only recently. Knowledge about children's psychological reactions is still lacking. The aim of the thesis was therefore to provide such knowledge in connection with the design of RPDs for use by children in chemical accidents and warfare. A battery of methods was validated and then used in three empirical studies. The first of these consisted of three experiments in which children's acceptance and other psychological reactions were observed when they put on different kinds of RPDs. Evacuation with RPDs to a shelter was investigated in the second study. In the third study, measurements of psychological reactions were repeatedly made during 6 hours in a simulated shelter. Forty four adults and 37 children younger than 15 months old with their parents participated in Experiment 3 of the first study. The results clearly suggested that a protective suit for both child and adult was preferred when the child is at this age. In Experiments 1 and 2 of the same study and in the second study, a protective jacket was compared to a protective mask. Subjects were 368 children between 2 and 7 years old. The results indicated that the protective mask was accepted by more children than the jacket was. However, in the second study, where children and adults evacuated, parents and daycare center staff were found to have difficulties in putting on the masks. Subjects in the third study were 118 children and youth between 7 and 20 years old. In an experimental condition, subjects wore a protective mask. A dust mask with no breathing resistance was worn in a control condition. Interviews wore performed every 30 minutes in the shelter. In both the experimental and control conditions, a majority of subjects were able to wear the protective mask for 6 hours. The interruptions which were observed occurred between 1.5 and 2.5 hours. The primary reason appeared to be lack of motivation, more pronounced in the younger than in the older children. The need was thus highlighted of adding sources of extrinsic motivation to force, in particular younger children not to interrupt. In summary, the results provide clear guidelines for what types of RPDs are psychologically suitable for children at different ages.
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| 5. |
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| 6. |
- Jianliang, Wang, et al.
(författare)
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Chinese coal supply and future production outlooks
- 2013
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Ingår i: Energy. - : Elsevier BV. - 0360-5442 .- 1873-6785. ; 60, s. 204-214
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Tidskriftsartikel (refereegranskat)abstract
- China's energy supply is dominated by coal, making projections of future coal production in China important. Recent forecasts suggest that Chinese coal production may reach a peak in 2010–2039 but with widely differing peak production levels. The estimated URR (ultimately recoverable resources) influence these projections significantly, however, widely different URR-values were used due to poor understanding of the various Chinese coal classification schemes. To mitigate these shortcomings, a comprehensive investigation of this system and an analysis of the historical evaluation of resources and reporting issues are performed. A more plausible URR is derived, which indicates that many analysts underestimate volumes available for exploitation. Projections based on the updated URR using a modified curve-fitting model indicate that Chinese coal production could peak as early as 2024 at a maximum annual production of 4.1 Gt. By considering other potential constraints, it can be concluded that peak coal in China appears inevitable and immediate. This event can be expected to have significant impact on the Chinese economy, energy strategies and GHG (greenhouse gas) emissions reduction strategies.
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