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1.	Chamakuri, Srinivas, et al. (author) A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay 2013 In: European Journal of Organic Chemistry. - : Wiley. - 1434-193X .- 1099-0690. ; :19, s. 3959-3964 Journal article (peer-reviewed)abstract A modular approach to explore the macrocyclic chemical space around an aminoindoline scaffold is developed. This is achieved by incorporating an amino acid moiety and subsequent stitching technology. Through screening of a zebrafish assay, several antiangiogenesis agents are identified.
2.	Guduru, Shiva Krishna Reddy, et al. (author) Tetrahydroquinoline-Derived Macrocyclic Toolbox : The Discovery of Antiangiogenesis Agents in Zebrafish Assay 2013 In: ACS Medicinal Chemistry Letters. - : American Chemical Society (ACS). - 1948-5875. ; 4:7, s. 666-670 Journal article (peer-reviewed)abstract A novel approach to incorporate the macrocyclic rings onto the privileged substructure, i.e. tetrahydroquinoline scaffold, is developed. The presence of an amino acid-derived moiety in the macrocyclic skeleton provides an opportunity to modulate the nature of the chiral side chain. Further, evaluation in a zebrafish screen identified three active small molecules (2.5b, 3.2d, and 4.2) as antiangiogenesis agents at 2.5 mu M.

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Author/Editor: Chandrasekar, Gayath ... (2); Kitambi, Satish Srin ... (2); Arya, Prabhat (2); Chamakuri, Srinivas (2); Guduru, Shiva Krishn ... (2); Pamu, Sreedhar (1)

Research subject (UKÄ/SCB): Natural sciences (2); Medical and Health Sciences (1)

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