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- Grigoryan, L, et al.
(författare)
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Self-medication with antimicrobial drugs in Europe
- 2006
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Ingår i: Emerging infectious diseases. - : Centers for Disease Control and Prevention (CDC). - 1080-6040 .- 1080-6059. ; 12:3, s. 452-459
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Tidskriftsartikel (refereegranskat)
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- Raja, Erum K., et al.
(författare)
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Friedel-Crafts Acylation with Amides
- 2012
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 77:13, s. 5788-5793
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: Friedel-Crafts acylation has been known since the 1870s, and it is an important organic synthetic reaction leading to aromatic ketone products. Friedel-Crafts acylation is usually performed with carboxylic acid chlorides or anhydrides, while amides are generally not useful substrates in these reactions. Despite being the least reactive carboxylic acid derivative, we have found a series of amides capable of providing aromatic ketones in good yields (55-96%, 17 examples). We propose a mechanism involving diminished C-N resonance through superelectrophilic activation and subsequent cleavage to acyl cations.
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