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- Jansson, Eva, 1971-
(author)
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Working together when being apart : An analysis of distributed collaborative work through ICT from an organizational and psychosocial perspective
- 2005
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Doctoral thesis (other academic/artistic)abstract
- The purpose of the research is to analyze collaboration and communication in distributed teams working together through ICT (Information and Communication Technology), to provide an overview and a broader understanding of important areas that require consideration. The analysis is from an organizational, psychosocial and managerial perspective, with the aim to support the development of strategies and the creation of more efficient and pleasant distributed work environments. Research questions concern the psychosocial work environment; differences, problems and opportunities for distributed teams, with deeper analysis of areas that was demonstrated particularly difficult. The analysis is concretized into advice to guide distributed teams; common problem areas are pointed out and an attempt on a theoretical model of distributed project work is made. A solid ground for continued research in the area as well as possibilities to support distributed teams is provided. The research was mainly conducted in globally distributed project courses at a university level, where students communicated and collaborated through ICT. The results apply on distributed projects, but can also be relevant for other areas in the new ICT facilitated work environment. The research has been conducted by investigating how team members behave in and perceive distributed work environments; analyzing how i.e. variations in organization, work, social activities and behavior affect how well the collaboration and communication work Teams working in distributed projects go through the same stages and encounter the same problems as any other team. Some problems become harder to overcome, there are new obstacles, at the same time as other problems become less noticeable and new opportunities arise. The base for collaboration and communication changes when team members don't see each other regularly. Teams are entailed to use ICT for basically all communication and various media demands alterations in behavior, as well as it alters the relation between senses and how people perceive things. Distributed team members don't have the same awareness of each other and get fewer cues to interpret situations and handle teambuilding, motivational problems and conflicts. Several of the regular ways to start socializing, build trust and get a common base for understanding and collaboration are not present in a distributed environment. There is no physical team space to meet in and team members don't "see" each other on a regular basis. It is possible to successfully work in distributed teams without regular face-to-face meetings even if it is more intricate. It will always be different, and the big danger is believing that it won't. Working in distributed teams is not necessarily worse, but there are no effortless solutions for replacing face-to-face encounters. Distributed projects require effort, but conducted right it can be a rewarding experience that brings an extra dimension to the project work. To make distributed projects work well it is necessary to consider technological issues as well as their effects on individuals. It is essential to understand the new issues people encounter when moving to a distributed work environment and the interrelations between different areas and variables.
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- Jansson, T., et al.
(author)
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Detection of magnetomotive ultrasound signals from human tissue
- 2023
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In: Nanomedicine-Nanotechnology Biology and Medicine. - : Elsevier BV. - 1549-9634. ; 47
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Journal article (peer-reviewed)abstract
- Rectal cancer is a common cancer, with presently a 5-year survival of 67 %. Treatment is based on tumor stage, but current staging methods, such as magnetic resonance imaging (MRI) or ultrasound, are limited in the ability to correctly stage the disease. Magnetomotive ultrasound is a developing modality that has a potential to improve rectal cancer staging. Magnetic nanoparticles are set in motion by an external magnetic field, and the resulting motion signature is detected by ultrasound. Here, we report on magnetomotive images of magnetic nanoparticles in human tissue, using a prototype system where a rotating permanent magnet provides the varying magnetic field, and an ultrasound transducer array encircling the magnet, detects the induced motion. Prior to surgery, a patient with a low rectal tumor was injected at three sites close to the tumor with magnetic nanoparticles. Postsurgical magnetomotive ultrasound scanning revealed the three injection sites, with no obvious artefactual signals. A phantom study showed detection of nanoparticles beyond 40 mm, where 30 mm is the expected maximum distance to mesorectal lymph nodes.Magnetomotive ultrasound image of iron oxide nanoparticles in human tissue. Prior to surgery a patient was injected with nanoparticles, and the excised tissue specimen was imaged with a prototype magnetomotive ultrasound system. The three colored areas overlaid on the standard B-mode greyscale image, correspond to the three injection sites.
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- Myhrinder, Anna Lanemo, 1975-, et al.
(author)
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Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia
- 2013
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 54:8, s. 1769-1779
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Journal article (peer-reviewed)abstract
- Chronic lymphocytic leukemia (CLL) B-cells resemble self-renewing CD5 + B-cells carrying auto/xeno-antigen-reactive B-cell receptors (BCRs) and multiple innate pattern-recognition receptors, such as Toll-like receptors and scavenger receptors. Integration of signals from BCRs with multiple surface membrane receptors determines whether the cells will be proliferating, anergic or apoptotic. To better understand the role of antigen in leukemogenesis, CLL cell lines producing monoclonal antibodies (mAbs) will facilitate structural analysis of antigens and supply DNA for genetic studies. We present here a comprehensive genotypic and phenotypic characterization of available CLL and normal B-cell-derived lymphoblastoid cell lines (LCLs) from the same individuals (n = 17). Authenticity and verification studies of CLL-patient origin were done by IGHV sequencing, fluorescence in situ hybridization (FISH) and DNA/short tandem repeat (STR) fingerprinting. Innate B-cell features, i.e. natural Ab production and CD5 receptors, were present in most CLL cell lines, but in none of the normal LCLs. This panel of immortalized CLL-derived cell lines is a valuable reference representing a renewable source of authentic Abs and DNA.
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- Rosén, Anders, et al.
(author)
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Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection
- 2012
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In: Oncoimmunology. - : Informa UK Limited. - 2162-4011 .- 2162-402X. ; 1:1, s. 18-27
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Journal article (peer-reviewed)abstract
- Chronic lymphocytic leukemia (CLL) cells express the receptor for Epstein-Barr virus (EBV) and can be infected in vitro. Infected cells do not express the growth-promoting set of EBV-encoded genes and therefore they do not yield LCLs, in most experiments. With exceptional clones, lines were obtained however. We describe a new line, HG3, established by in vitro EBV-infection from an IGHV1-2 unmutated CLL patient clone. All cells expressed EBNA-2 and LMP-1, the EBV-encoded genes pivotal for transformation. The karyotype, FISH cytogenetics and SNP-array profile of the line and the patient's ex vivo clone showed biallelic 13q14 deletions with genomic loss of DLEU7, miR15a/miR16-1, the two micro-RNAs that are deleted in 50% of CLL cases. Further features of CLL cells were: expression of CD5/CD20/CD27/CD43 and release of IgM natural antibodies reacting with oxLDL-like epitopes on apoptotic cells (cf. stereotyped subset-1). Comparison with two LCLs established from normal B cells showed 32 genes expressed at higher levels (> 2-fold). Among these were LHX2 and LILRA. These genes may play a role in the development of the disease. LHX2 expression was shown in self-renewing multipotent hematopoietic stem cells, and LILRA4 codes for a receptor for bone marrow stromal cell antigen-2 that contributes to B cell development. Twenty-four genes were expressed at lower levels, among these PARD3 that is essential for asymmetric cell division. These genes may contribute to establish precursors of CLL clones by regulation of cellular phenotype in the hematopoietic compartment. Expression of CD5/CD20/CD27/CD43 and spontaneous production of natural antibodies may identify the CLL cell as a self-renewing B1 lymphocyte.
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- Rundqvist, Håkan Claes, et al.
(author)
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Influence of nutrient ingestion on amino acid transporters and protein synthesis in human skeletal muscle after sprint exercise
- 2017
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In: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 123:6, s. 1501-1515
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Journal article (peer-reviewed)abstract
- Nutrient ingestion is known to increase the exercise-induced stimulation of muscle protein synthesis following resistance exercise. Less is known about the effect of nutrients on muscle protein synthesis following sprint exercise. At two occasions separated by one month, twelve healthy subjects performed three 30-s sprints with 20-min rest between bouts. In randomized order, they consumed a drink with essential amino acids and maltodextrin (nutrient) or flavored water (placebo). Muscle biopsies were obtained 80 and 200 min after the last sprint and blood samples were taken repeatedly during the experiment. Fractional synthetic rate (FSR) was measured by continuous infusion of L-[(2)H5]-phenylalanine up to 200 min postexercise. The mRNA and protein expression of SNAT2 were both 1.4-fold higher (P < 0.05) after nutrient intake compared to placebo at 200 min postexercise. Phosphorylated Akt, mTOR and p70S6k was 1.7- to 3.6-fold higher (P<0.01) 80 min after the last sprint with nutrient ingestion as compared to placebo. In addition, FSR was higher (P<0.05) with nutrients when plasma phenylalanine (FSRplasma) was used as a precursor, but not when intracellular phenylalanine (FSRmuscle) was used. Significant correlations were also found between FSRplasma on the one hand and plasma leucine and serum insulin on the other hand in the nutrient condition. The results show that nutrient ingestion induces the expression of the amino acid transporter SNAT2, stimulates Akt/mTOR signaling and most likely the rate of muscle protein synthesis following sprint exercise.
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- Aasa, Ulrika, et al.
(author)
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Hälsoresan till medelåldern
- 2011
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In: Svensk Idrottsforskning. - : Centrum för idrottsforskning. - 1103-4629. ; :2, s. 40-43
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Journal article (other academic/artistic)abstract
- Vad är viktigast för att få en god hälsa som vuxen? Sedan 1974 har vi följt samma personer från 16 års ålder in i medelåldern och studerat deras hälsa från flera olika synvinklar. Nu pågår den tredje mätomgången.
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