| 1. |
- Campbell, Kate, 1987, et al.
(författare)
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Cell-to-cell heterogeneity emerges as consequence of metabolic cooperation in a synthetic yeast community
- 2016
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Ingår i: Biotechnology journal. - : Wiley. - 1860-6768 .- 1860-7314. ; 11:9, s. 1169-1178
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Tidskriftsartikel (refereegranskat)abstract
- Cells that grow together respond heterogeneously to stress even when they are genetically similar. Metabolism, a key determinant of cellular stress tolerance, may be one source of this phenotypic heterogeneity, however, this relationship is largely unclear. We used self-establishing metabolically cooperating (SeMeCo) yeast communities, in which metabolic cooperation can be followed on the basis of genotype, as a model to dissect the role of metabolic cooperation in single-cell heterogeneity. Cells within SeMeCo communities showed to be highly heterogeneous in their stress tolerance, while the survival of each cell under heat or oxidative stress, was strongly determined by its metabolic specialization. This heterogeneity emerged for all metabolite exchange interactions studied (histidine, leucine, uracil, and methionine) as well as oxidant (H2O2, diamide) and heat stress treatments. In contrast, the SeMeCo community collectively showed to be similarly tolerant to stress as wild-type populations. Moreover, stress heterogeneity did not establish as sole consequence of metabolic genotype (auxotrophic background) of the single cell, but was observed only for cells that cooperated according to their metabolic capacity. We therefore conclude that phenotypic heterogeneity and cell to cell differences in stress tolerance are emergent properties when cells cooperate in metabolism.
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| 2. |
- Aad, G., et al.
(författare)
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- 2013
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :11
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Aad, G., et al.
(författare)
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- 2014
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Kuhlmann, Marco, 1977-, et al.
(författare)
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A New Parsing Algorithm for Combinatory Categorial Grammar
- 2014
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Ingår i: Transactions of the Association for Computational Linguistics. - : Association for Computational Linguistics. - 2307-387X. ; 2:2014, s. 405-418
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Tidskriftsartikel (refereegranskat)abstract
- We present a polynomial-time parsing algorithm for CCG, based on a new decomposition of derivations into small, shareable parts. Our algorithm has the same asymptotic complexity, O(n⁶), as a previous algorithm by Vijay-Shanker and Weir (1993), but is easier to understand, implement, and prove correct.
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| 5. |
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| 6. |
- Kuhlmann, Marco, 1977-, et al.
(författare)
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Dynamic Programming Algorithms for Transition-Based Dependency Parsers
- 2011
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Ingår i: Proceedings of the 49th Annual Meeting of the Association for Computational Linguistics. - Stroudsburg, PA, USA : Association for Computational Linguistics. - 9781932432879 ; , s. 673-682
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Konferensbidrag (refereegranskat)abstract
- We develop a general dynamic programming technique for the tabulation of transition-based dependency parsers, and apply it to obtain novel, polynomial-time algorithms for parsing with the arc-standard and arc-eager models. We also show how to reverse our technique to obtain new transition-based dependency parsers from existing tabular methods. Additionally, we provide a detailed discussion of the conditions under which the feature models commonly used in transition-based parsing can be integrated into our algorithms.
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| 7. |
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| 8. |
- Aad, G., et al.
(författare)
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- 2011
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swepub:Mat__t (refereegranskat)
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| 9. |
- Bittererova, M., et al.
(författare)
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A theoretical study of the azide (N-3) doublet states. A new route to tetraazatetrahedrane (N-4) : N+N-3 -> N-4
- 2002
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 116:22, s. 9740-9748
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Tidskriftsartikel (refereegranskat)abstract
- The potential energy surfaces for the low-lying doublet states of the azide radical (N-3) have been computed at the complete active space self-consistent field (CASSCF) level with the CAS(15,12) active space. The cc-pVTZ and aug-cc-pVTZ basis sets have been employed throughout the present work. Energies, geometries and harmonic frequencies were determined for the N-3 linear ground electronic state ((2)Pi(g)), a stable C-2v ring structure (B-2(1)), and a C-s transition state ((2)A(')) connecting the ring and linear structures. Other N-3 (C-2v) stationary points ((2)A(2), B-2(1), and (2)A(1)) have been characterized, as well. The vertical excitation energies for the doublet excited states of the N-3 linear ((2)Pi(g)) and stable ring (B-2(1)) isomers were calculated using CASSCF and multireference configuration interaction [MRCI-SD(Q)] methods. A new route to tetraazatetrahedrane [N-4(T-d)] has been proposed on the N-4 singlet potential energy surface within C-s symmetry. MRCI-SD(Q) calculations predict that N-4 (T-d) can be formed from atomic nitrogen in the D-2 state and N-3 (C-2v, B-2(1)) in a barrierless exothermic reaction. The energy difference (D-0) is 135.4 kcal/mol at the MRCI-SD(Q) level.
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| 10. |
- Khatibi, Ali, 1982-
(författare)
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Face-Centered Cubic (Al1-xCrx)2O3 Thin Films : Deposition, Characterization, and Heat Treatment Studies
- 2011
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Face centered cubic (Al1-xCrx)2O3 solid solution films, with x in the range 0.602 discharge at a substrate temperature of 500 °C. The films have a strong <100> preferred orientation. The unit cell parameter is 4.04 Å determined by x-ray diffraction and high resolution transmission electron microscopy techniques. The (Al1-xCrx)2O3 films are suggested to have a non-stoichiometric NaCl structure with 33% vacancy occupancy on Al/Cr sites. Nanoindentation shows that the films exhibit hardness values up to 26 GPa and reduced modulus of 220-235 GPa. In the present work, ex-situ annealing studies were performed on as-deposited samples for a series of temperatures up to 1100 °C and annealing time of 2,4,6,8, and 10 hours. The fcc structure remains intact up to 950 °C. A gradual phase transformation from fcc to corundum at 925 °C is observed, where annealing for 2 h yields a partial transformation and annealing for >6 h results in complete transformation to a-(Al1-xCrx)2O3. There is no indication of any phase separation into a-Cr2O3 and Al2O3.
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