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- Andersson, Rolf G, et al.
(author)
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Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils
- 1989
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In: Agents and actions. - 0065-4299. ; 27:1-2, s. 25-28
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Journal article (peer-reviewed)abstract
- Human basophils became hyporesponsive to anti-IgE when exposed to this agent in the absence of Ca2+ for more than 10 min. The desensitization process proceeded in parallel to the releasing-process. The mechanism of desensitization seems to involve a very early step in the release-reaction, since the response to phospholipase A2 and diolein, agents involved in the release-reaction, was not affected by the desensitization.
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