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- Møller Nielsen, L., et al.
(författare)
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Design based entrepreneurship
- 2013
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Konferensbidrag (refereegranskat)abstract
- Designers are often recognized as natural entrepreneurs, due to their creative skills and competences in the idea-generation and product development processes. A number of studies shows that creative professionals are more likely to become self-employed. In general though, there are not many studies on design entrepreneurs, and those who has been made, focus on design entrepreneurs' lack business competences in administration, marketing and operation, as well as their lack of skills and priority, when it comes to the development of their businesses. This study will nuance this picture of the design entrepreneur by building upon a new direction within entrepreneurial research, which focuses on entrepreneurial expertise and logic. At a theoretical level, we will show that there are some overlap between the expert entrepreneurial logic (effectuation) and the 'designerly ways of knowing and doing'. We review three cases with novice design entrepreneurs, where we have been able to identify examples of the novice design entrepreneurs using 'effectual logic'. The examples are described and analysed using Sarasvathys 5 principles, showing that 3 of 5 principles are found in the cases.
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- Husz, Orsi, 1969-
(författare)
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Även för hundra år sedan mätte vi tillvaron i pengar
- 2011
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Ingår i: Tvärsnitt : humanistisk och samhällsvetenskaplig forskning. - Stockholm : Vetenskapsrådet. - 0348-7997. ; :1, s. 6-10
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Kimani-Murage, Elizabeth W, et al.
(författare)
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'You opened our eyes' : care-giving after learning a child's positive HIV status in rural South Africa
- 2010
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Ingår i: Health & Social Care in the Community. - : Hindawi Limited. - 0966-0410 .- 1365-2524. ; 18:3, s. 264-271
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Tidskriftsartikel (refereegranskat)abstract
- Caregivers of young children identified as HIV positive, residing in Agincourt, rural South Africa were advised of their child's status. How was this knowledge received, and how did it influence care-giving and support? Interviews were conducted in May to June 2008 with caregivers of HIV positive children aged 1-5 years, 1 year following the child's HIV test and disclosure of status. Drawing on data from 31 semi-structured questionnaires and 21 in-depth interviews, we describe caregivers' attitudes, reactions, fears and aspirations after learning a child's HIV status, the perceived usefulness of the knowledge, barriers to care-giving and support received. Sociodemographic data collected through the questionnaire were analysed using Stata. Qualitative data were coded in NVIVO 8 and analysed inductively to identify themes and their repetitions and variations. Although almost half of the caregivers responded negatively initially, 1 year later, almost all had accepted and valued knowing their child's HIV status as this had enhanced their competency in care-giving. Counselling from health providers and personal spirituality helped caregivers to accept the child's status and cope with its implications. Most caregivers had high aspirations for the child's future, despite some expressed difficulties associated with care-giving, including financial constraints, information gaps and barriers to healthcare. The results indicate an opportunity for paediatric HIV screening in communities with high HIV prevalence. This would facilitate early uptake of available interventions, so enhancing the survival of HIV positive children.
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- Møller-Olsen, Astrid
(författare)
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House Without a Ceiling : Uncanny places in the works of Can Xue
- 2015
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In the works of Can Xue, houses and buildings act as the outer shell of the fragile self. Her depiction of these uncanny places of inhabitance questions the rationalist notion of an objective border between self and surroundings, paving the way for a subjective and phenomenological approach to reality.
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- Tran, Thi Thuy, 1980-
(författare)
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Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. The cost and efficiency of characterization affect the speed to market of biopharmaceutical proteins. A reduction in the number of manual processing steps, cost of reagents and consumption of sample, as well as the time required for chemical analysis, is therefore necessary.The research presented in this thesis is focused on the potential of using microfluidic discs for automated, miniaturized, parallel and rapid sample preparation for PTM characterization of therapeutic monoclonal antibodies. Paper I describes the method development for N-linked glycosylation profiling. Several sample preparation steps have been performed in an integrated process in the microfluidic compact disc (CD). Paper II demonstrates the use of the method presented in paper I in combination with multivariate statistics for discrimination of glycosylation profiles of different therapeutic antibodies and simulation of a real case of quality control. Paper III is focused on a method for monitoring changes in glycosylation profiles of therapeutic antibodies in serum over time by incubation with an exoglycosidase enzyme. Paper IV describes the method for peptide mapping of therapeutic antibodies. In addition, recent work (unpublished results) assesses the potential of this method for methionine oxidation detection.The developed methods were fast, robust with low sample/reagent consumption. Generation of glycosylation profile data for one sample was established in approximately 2 h. The amount of samples and antigens loaded into the CD platform for one replicate was less than 0.3 μg and approximately 0.06 μg, respectively. Furthermore, considering the parallel function of the CD, conducting the analysis for 54 samples can be completed within a day.
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