| 1. |
- Abdellah, Tebani, et al.
(författare)
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Integration of molecular profiles in a longitudinal wellness profiling cohort.
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies andimmune cell profiling, complementedwith gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
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| 2. |
- Bridel, Claire, et al.
(författare)
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Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology : A Systematic Review and Meta-analysis
- 2019
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Ingår i: JAMA Neurology. - : American Medical Association (AMA). - 2168-6149 .- 2168-6157. ; 76:9, s. 1035-1048
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Forskningsöversikt (refereegranskat)abstract
- Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date.Objectives To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating clinically similar conditions.Data Sources PubMed was searched for studies published between January 1, 2006, and January 1, 2016, reporting cNfL levels (using the search terms neurofilament light and cerebrospinal fluid) in neurological or psychiatric conditions and/or in HC.Study Selection Studies reporting NfL levels measured in lumbar CSF using a commercially available immunoassay, as well as age and sex.Data Extraction and Synthesis Individual-level data were requested from study authors. Generalized linear mixed-effects models were used to estimate the fixed effects of age, sex, and diagnosis on log-transformed NfL levels, with cohort of origin modeled as a random intercept.Main Outcome and Measure The cNfL levels adjusted for age and sex across diagnoses.Results Data were collected for 10 059 individuals (mean [SD] age, 59.7 [18.8] years; 54.1% female). Thirty-five diagnoses were identified, including inflammatory diseases of the central nervous system (n = 2795), dementias and predementia stages (n = 4284), parkinsonian disorders (n = 984), and HC (n = 1332). The cNfL was elevated compared with HC in a majority of neurological conditions studied. Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and Huntington disease. In 33.3% of diagnoses, including HC, multiple sclerosis, Alzheimer disease (AD), and Parkinson disease (PD), cNfL was higher in men than women. The cNfL increased with age in HC and a majority of neurological conditions, although the association was strongest in HC. The cNfL overlapped in most clinically similar diagnoses except for FTD and iHIV, which segregated from other dementias, and PD, which segregated from atypical parkinsonian syndromes.Conclusions and Relevance These data support the use of cNfL as a biomarker of neuroaxonal damage and indicate that age-specific and sex-specific (and in some cases disease-specific) reference values may be needed. The cNfL has potential to assist the differentiation of FTD from AD and PD from atypical parkinsonian syndromes.
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| 3. |
- Hu, Min, 1979-, et al.
(författare)
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Grading of sawn timber using the vibration technique : locating imperfections based on flexural mode shapes
- 2011
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Ingår i: 17th international nondestructive testing and evaluation of wood symposium. - Sopron, Hungary : University of West Hungary. - 9789639883819 ; , s. 269-276
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Konferensbidrag (refereegranskat)abstract
- The present study aims at investigating the potential of using mode shape or mode shape curvature (MSC) for detecting defects in wooden beams. It includes modal analysis, Finite Element (FE) modeling and visual scanning. An FE model was created to investigate the effect of defects of different size and location on the mode shape/MSC. The mode shape/MSC showed a good potential to be used for finding defects. An experimental study on 17 boards of Norway spruce, dimensions of 50×150×3900 mm, was conducted using experimental modal analysis. The findings reveal that: (1) the mode shape/MSC studied in the FE-model could be used to locate defects, (2) the method is very sensitive to measurement noise and it requires an accurately measured mode shape, (3) an error analysis shows that it is not possible to achieve the accuracy needed using accelerometers.
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| 4. |
- Wallin, Anders, 1950, et al.
(författare)
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Alzheimer's disease-subcortical vascular disease spectrum in a hospital-based setting: overview of results from the Gothenburg MCI and dementia studies.
- 2016
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Ingår i: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 1559-7016. ; 36:1, s. 95-113
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Forskningsöversikt (refereegranskat)abstract
- The ability to discriminate between Alzheimer's disease (AD), subcortical vascular disease, and other cognitive disorders is crucial for diagnostic purposes and clinical trial outcomes. Patients with primarily subcortical vascular disease are unlikely to benefit from treatments targeting the AD pathogenic mechanisms and vice versa. The Gothenburg mild cognitive impairment (MCI) and dementia studies are prospective, observational, single-center cohort studies suitable for both cross-sectional and longitudinal analysis that outline the cognitive profiles and biomarker characteristics of patients with AD, subcortical vascular disease, and other cognitive disorders. The studies, the first of which started in 1987, comprise inpatients with manifest dementia and patients seeking care for cognitive disorders at an outpatient memory clinic. This article gives an overview of the major published papers (neuropsychological, imaging/physiology, and neurochemical) of the studies including the ongoing Gothenburg MCI study. The main findings suggest that subcortical vascular disease with or without dementia exhibit a characteristic neuropsychological pattern of mental slowness and executive dysfunction and neurochemical deviations typical of white matter changes and disturbed blood-brain barrier function. Our findings may contribute to better healthcare for this underrecognized group of patients. The Gothenburg MCI study has also published papers on multimodal prediction of dementia, and cognitive reserve.Journal of Cerebral Blood Flow & Metabolism advance online publication, 29 July 2015; doi:10.1038/jcbfm.2015.148.
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| 5. |
- Wallin, Anders, 1950, et al.
(författare)
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The Gothenburg MCI study: design and distribution of Alzheimer's disease and subcortical vascular disease diagnoses from baseline to 6-year follow-up.
- 2016
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Ingår i: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 1559-7016. ; 36:1, s. 114-131
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Tidskriftsartikel (refereegranskat)abstract
- There is a need for increased nosological knowledge to enable rational trials in Alzheimer's disease (AD) and related disorders. The ongoing Gothenburg mild cognitive impairment (MCI) study is an attempt to conduct longitudinal in-depth phenotyping of patients with different forms and degrees of cognitive impairment using neuropsychological, neuroimaging, and neurochemical tools. Particular attention is paid to the interplay between AD and subcortical vascular disease, the latter representing a disease entity that may cause or contribute to cognitive impairment with an effect size that may be comparable to AD. Of 664 patients enrolled between 1999 and 2013, 195 were diagnosed with subjective cognitive impairment (SCI), 274 with mild cognitive impairment (MCI), and 195 with dementia, at baseline. Of the 195 (29%) patients with dementia at baseline, 81 (42%) had AD, 27 (14%) SVD, 41 (21%) mixed type dementia (=AD+SVD=MixD), and 46 (23%) other etiologies. After 6 years, 292 SCI/MCI patients were eligible for follow-up. Of these 292, 69 (24%) had converted to dementia (29 (42%) AD, 16 (23%) SVD, 15 (22%) MixD, 9 (13%) other etiologies). The study has shown that it is possible to identify not only AD but also incipient and manifest MixD/SVD in a memory clinic setting. These conditions should be taken into account in clinical trials.Journal of Cerebral Blood Flow & Metabolism advance online publication, 15 July 2015; doi:10.1038/jcbfm.2015.147.
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| 6. |
- Abbadi, Ahmad, et al.
(författare)
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Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care
- 2024
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Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: As global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes paramount. The aim of this study is to assess the validity of the comprehensive clinical and functional Health Assessment Tool (HAT) based on four cohorts of older adults (60 + years) from the Swedish National study on Aging and Care (SNAC) spanning urban, suburban, and rural areas.Methods: The HAT integrates five health indicators (gait speed, global cognition, number of chronic diseases, and basic and instrumental activities of daily living), providing an individual-level score between 0 and 10. The tool was constructed using nominal response models, first separately for each cohort and then in a harmonized dataset. Outcomes included all-cause mortality over a maximum follow-up of 16 years and unplanned hospital admissions over a maximum of 3 years of follow-up. The predictive capacity was assessed through the area under the curve (AUC) using logistic regressions. For time to death, Cox regressions were performed, and Harrell’s C-indices were reported. Results from the four cohorts were pooled using individual participant data meta-analysis and compared with those from the harmonized dataset.Results: The HAT demonstrated high predictive capacity across all cohorts as well as in the harmonized dataset. In the harmonized dataset, the AUC was 0.84 (95% CI 0.81–0.87) for 1-year mortality, 0.81 (95% CI 0.80–0.83) for 3-year mortality, 0.80 (95% CI 0.79–0.82) for 5-year mortality, 0.69 (95% CI 0.67–0.70) for 1-year unplanned admissions, and 0.69 (95% CI 0.68–0.70) for 3-year unplanned admissions. The Harrell’s C for time-to-death throughout 16 years of follow-up was 0.75 (95% CI 0.74–0.75).Conclusions: The HAT is a highly predictive, clinically intuitive, and externally valid instrument with potential for better addressing older adults’ health needs and optimizing risk stratification at the population level. © The Author(s) 2024.
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| 7. |
- Balachandramurthi, Arun Ramanathan, 1989-, et al.
(författare)
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Microstructure tailoring in Electron Beam Powder Bed Fusion Additive Manufacturing and its potential consequences
- 2019
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Ingår i: Results in Materials. - : Elsevier. - 2590-048X. ; 1
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Tidskriftsartikel (refereegranskat)abstract
- Electron Beam Powder Bed Fusion process for Alloy 718 was investigated, in the sense of microstructural evolution with varying process conditions. The existence of a geometric relationship between the melt front and the processing parameters was observed. By understanding and capitalizing on this relationship, it was possible to obtain columnar, equiaxed or bimodal microstructure.
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| 8. |
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| 9. |
- Hu, Min, 1979-, et al.
(författare)
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Assessment of a Three-Dimensional Fiber Orientation Model for Timber
- 2016
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Ingår i: Wood and Fiber Science. - 0735-6161. ; 48:4, s. 271-290
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Tidskriftsartikel (refereegranskat)abstract
- Wood is an orthotropic material with very different properties along and across fibers, and every board has its own pattern of knots and fiber deviations. Therefore, detailed knowledge of the three-dimensional (3D) fiber orientation of individual boards would enable more accurate assessment of properties such as stiffness, strength, and shape stability. This paper presents a method for modeling 3D fiber orientation of side boards of Norway spruce. The method is based on dot laser scanning and utilization of the tracheid effect, and it is verified by a comparison between strain fields calculated on the basis of the fiber orientation model and corresponding strains determined using digital image correlation (DIC) technique. By means of the method, it is possible to identify knots and to reproduce the fiber orientation in clear wood in the vicinity of knots. Fiber orientation models of side boards including traversing edge knots were established and integrated in finite element models of boards used for simulation of four-point bending tests. The same boards were also tested in laboratory and displacement fields of the wide faces were recorded at different load levels using DIC technique. Comparisons of strain fields from measurements and simulations showed close agreement, regarding both strain patterns and strain levels. Local strain concentrations caused by very small defects were detected using the models and also found from the laboratory test results. The modeling approach may be used both to achieve improved accuracy of existing machine strength grading methods and, after further development, also for more advanced analysis of eg crack propagation and strength of timber.
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| 10. |
- Hu, Min, 1979-, et al.
(författare)
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Growth layer and fibre orientation around knots in Norway spruce : a laboratory investigation
- 2018
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Ingår i: Wood Science and Technology. - : Springer. - 0043-7719 .- 1432-5225. ; 52:1, s. 7-27
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Tidskriftsartikel (refereegranskat)abstract
- The strength of structural timber largely depends on the occurrence of knots and on the local material directions in the surroundings of such knots. There is, however, a lack of methods for establishing a full dataset of the local material directions. The present research aims at the development and application of a laboratory method to assess the geometry of growth layers and the orientation of fibres in a high-resolution 3D grid within wood specimens containing knots. The laboratory method was based on optical flatbed scanning and laser scanning, the former resulting in surface images and the latter, utilizing the tracheid effect, resulting in in-plane fibre angles determined in high-resolution grids on scanned surfaces. A rectangular solid wood specimen containing a single knot was cut from a tree in such a way that it could be assumed that a plane of symmetry existed in the specimen. By splitting the specimen through this plane through the centre line of the knot, two new specimens with assumed identical but mirrored properties were achieved. On one of the new specimens, the longitudinal-radial plane was subsequently scanned, and the longitudinal–tangential plane was scanned on the other. Then, by repeatedly planing off material on both specimens followed by scanning of the new surfaces that gradually appeared, 3D coordinate positions along different growth layers and 3D orientation of fibres in a 3D grid were obtained. Comparisons between detected fibre orientation and growth layer geometry were used for the assessment of the accuracy obtained regarding 3D fibre orientation. It was shown that the suggested method is well suited to capture growth layer surfaces and that it provides reliable information on 3D fibre orientation close to knots. Such knowledge is of great importance for understanding the properties of timber including knots. The quantitative data obtained are also useful for calibration of model parameters of general models on fibre orientation close to knots.
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