| 1. |
- Aad, G., et al.
(författare)
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- 2013
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :10
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Adamina, Michel, et al.
(författare)
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ECCO Topical Review Optimising Reporting in Surgery, Endoscopy, and Histopathology Collaboration Between S-ECCO, EduCom, H-ECCO
- 2021
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Ingår i: Journal of Crohn's & Colitis. - : OXFORD UNIV PRESS. - 1873-9946 .- 1876-4479. ; 15:7, s. 1089-1105
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Forskningsöversikt (refereegranskat)abstract
- Background and Aims: Diagnosis and management of inflammatory bowel diseases [IBD] requires a lifelong multidisciplinary approach.The quality of medical reporting is crucial in this context.The present topical review addresses the need for optimised reporting in endoscopy, surgery, and histopathology. Methods: A consensus expert panel consisting of gastroenterologists, surgeons, and pathologists, convened by the European Crohns and Colitis Organisation, performed a systematic literature review. The following topics were covered: in endoscopy: [i] general IBD endoscopy; [ii] disease activity and surveillance; [iii] endoscopy treatment in IBD; in surgery: [iv] medical history with surgical relevance, surgical indication, and strategy; [v] operative approach; [vi] intraoperative disease description; [vii] operative steps; in pathology: [viii] macroscopic assessment and interpretation of resection specimens; [ix] IBD histology, including biopsies, surgical resections, and neoplasia; [x] IBD histology conclusion and report. Statements were developed using a Delphi methodology incorporating two consecutive rounds. Current practice positions were set when >= 80% of participants agreed on a recommendation. Results: Thirty practice positions established a standard terminology for optimal reporting in endoscopy, surgery, and histopathology. Assessment of disease activity, surveillance recommendations, advice to surgeons for operative indication and strategies, including margins and extent of resection, and diagnostic criteria of IBD, as well as guidance for the interpretation of dysplasia and cancer, were handled. A standardised report including a core set of items to include in each specialty report, was defined. Conclusions: Interdisciplinary high-quality care requires thorough and standardised reporting across specialties.This topical review offers an actionable framework and practice recommendations to optimise reporting in endoscopy, surgery, and histopathology.
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| 3. |
- Pini, Alessia, 1985-, et al.
(författare)
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Test-retest reliability measures for curve data : an overview with recommendations and supplementary code.
- 2022
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Ingår i: Sports Biomechanics. - : Routledge. - 1476-3141 .- 1752-6116. ; 21:2, s. 179-200
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this paper is to provide an overview of available methods for reliability investigations when the outcome of interest is a curve. Curve data, or functional data, is commonly collected in biomechanical research in order to better understand different aspects of human movement. Using recent statistical developments, curve data can be analysed in its most detailed form, as functions. However, an overview of appropriate statistical methods for assessing reliability of curve data is lacking. A review of contemporary literature of reliability measures for curve data within the fields of biomechanics and statistics identified the following methods: coefficient of multiple correlation, functional limits of agreement, measures of distance and similarity, and integrated pointwise indices (an extension of univariate reliability measures to curve data, inclusive of Pearson correlation, intraclass correlation, and standard error of measurement). These methods are briefly presented, implemented (R-code available as supplementary material) and evaluated on simulated data to highlight advantages and disadvantages of the methods. Among the identified methods, the integrated intraclass correlation and standard error of measurement are recommended. These methods are straightforward to implement, enable results over the domain, and consider variation between individuals, which the other methods partly neglect.
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| 4. |
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| 5. |
- Goepfert, Caroline, et al.
(författare)
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Elite cross-country skiers’ adaptations of the diagonal stride technique at different inclinations
- 2009
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Konferensbidrag (refereegranskat)abstract
- Introduction: Despite the equal relevance of classic and freestyle in modern cross-country skiing, the main focus of biomechanical studies has mainly been on the latter technique. Diagonal stride [DIA] as a main classical technique has further developed over the last 20 years. There is still a lack of biomechanical data describing DIA and adaptations to different inclinations. A previous study showed that skiers increased cycle rate rather than cycle length as the strategy to adapt to increasing inclinations (Bilodeau et al. 1992). However, no kinetic or joint kinematic data were presented. The aim of the present study was to identify kinetic and kinematic adaptations in DIA at different inclinations. Methods: Twelve elite XC skiers (Swedish National Team; VO2max-DIA: 72.3 ± 3.8 ml·kg-1·min-1) performed DIA roller skiing at treadmill inclinations of 3°, 6° and 9° at 11 km·h-1 for biomechanical analyses. Leg and arm joint angles (goniometers), pole force (strain gauge), both at 2000 Hz, and plantar force (Pedar Mobile) at 100 Hz were recorded. Repeated measures ANOVA were calculated in order to examine the biomechanical differences between the named inclinations. The statistical level of significance was set at P<0.05. Results: Cycle time [CT] (P<0.01) and relative (%CT) arm recovery time (P<0.05) decreased at higher inclinations. Cycle rate and relative poling time both increased (both P<0.01). No differences were found for the relative durations of leg-ground contact and leg swing. All the force values measured were greatest at the steepest inclination, including peak pole and leg forces, forefoot force in ground position and impulses of pole and leg push-off (all P<0.01). Elbow [EA], hip [HA] and knee [KA] angle minima, EA at pole plant, KA at ski plant and HAmaximum before push-off decreased (all P<0.01). The elbow extension range of motion [ROM] and knee (both P<0.01), as well as hip push-off extension ROM (P<0.05), increased with inclination. Angular push-off flexion velocity (P<0.01) decreased, along with higher angular push-off extension velocities in the ankle (P<0.05), knee and hip joints (both P<0.01) at steeper inclinations. Conclusion: Elite skiers adapt the DIA technique to increased inclinations through substantial changes in pole and leg kinetics and joint kinematics, with only minor changes in specific phase durations. Arm and leg actions show larger amplitudes, higher angular velocities, longer poling times, higher forces and impulses generated at higher frequencies. We suggest that XC skiers should use technique, endurance and strength training at different inclinations in order to train these aspects specifically.
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| 6. |
- Cricchio, Giovanni, 1968-, et al.
(författare)
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Sinus bone formation and implant survival after sinus membrane elevation and implant placement: a 1- to 6-year follow-up study.
- 2011
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Ingår i: Clinical oral implants research. - Copenhagen : Wiley. - 1600-0501 .- 0905-7161. ; 22:10, s. 1200-1212
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To investigate the long-term clinical and radiographic results of the maxillary sinus membrane elevation technique where implants were inserted in a void space created by the elevation of the sinus membrane without adding any graft material. Materials and methods: A total of 84 patients were subjected to 96 membrane elevation procedures and simultaneous placement of 239 implants. Changes of intra-sinus and marginal bone height in relation to the implants were measured in intraoral radiographs taken at insertion, after 6 months of healing, after 6 months of loading and then annually. Computerized tomography was performed pre-surgically and 6 months post-surgically. Resonance Frequency Analyses measurements were performed at the time of implants placement, at abutment connection and after 6 months of loading. The implant follow-up period ranged from a minimum of one to a maximum of 6 years after implants loading. Results: All implants were stable after 6 months of healing. A total of three implants were lost during the follow-up period giving a survival rate of 98.7%. Radiography demonstrated on average 5.3±2.1 mm of intra-sinus new bone formation after 6 months of healing. RFA measurements showed adequate primary stability (implant stability quotient 67.4±6.1) and small changes over time. Conclusion: Maxillary sinus membrane elevation and simultaneous placement of implants without the use of bone grafts or bone substitutes result in predictable bone formation with a high implant survival rate of 98.7% during a follow-up period of up to 6 years. The intra-sinus bone formation remained stable in the long-term follow-up. It is suggested that the secluded compartment allowed for bone formation according to the principle of guided tissue regeneration. The high implant survival rate of 98.7% indicated that the implants sufficiently supported the fixed bridges throughout the study period. This technique reduces the risks for morbidity related to harvesting of bone grafts and eliminates the costs of grafting materials.
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| 7. |
- Laitinen, Mikko, 1973-, et al.
(författare)
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Charting New Sources of elf Data : A Multi-Genre Corpus Approach
- 2019
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Ingår i: From Data to Evidence in English Language Research. - Leiden : Brill Academic Publishers. - 9789004390652 - 9789004390645 ; , s. 326-350
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Bokkapitel (refereegranskat)abstract
- The article discusses research that charts new lingua franca English data and broadensthe scope of written elf corpora. We illustrate that, apart from the academic domain,there exist various written genres in non-native contexts in which English is used as asecond language resource alongside native languages. These uncharted data can provideus with new ways of approaching the ongoing globalization of English. The newapproach incorporates a broader perspective on elf than previously, seeing it as onestage in the long diachronic continuum of Englishes rather than as an entity emergingin interaction. The first part details a corpus project that produces written multi-genrecorpora suitable for real-time studies of how ongoing variability is reflected in linguafranca use. It is followed by three case studies investigating quantitative patterns ofongoing change in elf. The conclusions suggest that a diachronically-informed angleto lingua franca use offers a new vantage point not only to elf but also to ongoinggrammatical variability. It shows that the traditional and canonized way of seeing nonnativespeakers/writers is not sufficient, nor is the simplified view of norm dependency of non-native individuals.
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| 8. |
- Sani, Marc-Antoine, et al.
(författare)
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Magic-angle phosphorus NMR of functional mitochondria : in situ monitoring of lipid response under apoptotic-like stress
- 2009
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Ingår i: The FASEB Journal. - : The Federation of American Societies for Experimental Biology. - 0892-6638 .- 1530-6860. ; 23:9, s. 2872-2878
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Tidskriftsartikel (refereegranskat)abstract
- Using a noninvasive, solid-state magic-angle spinning nuclearmagnetic resonance (MAS NMR) approach, we track ex vivo thebehavior of individual membrane components in isolated, activemitochondria (model system: potato tubers) during physiologicalprocesses. The individual phosphatidylcholine (PC), phosphatidylethanolamine(PE), and cardiolipin (CL) membrane constituents were identifiedas distinct lines by applying MAS 31P NMR on extracted lipidmembranes. However, the CL NMR signal appeared to be very broadin functional mitochondria, indicating a tight complex formationwith membrane protein. Calcium stress induced severe membranedegradation without recovery of a single CL NMR resonance. Thissuggests that calcium overload destroys the outer mitochondrialmembrane and does not modify strongly the CL protein complexesin the inner membrane; a conclusion confirmed by respiratorycontrols. Conversely, mitochondrial membrane disruption on timedegradation or mechanical stress generates clearly visible identicalCL NMR signals, similar to those observed in rehydrated lipidextracts. Similarly, noninvasive based NMR tracking of lipidsin response to diverse physiological stimuli can easily be usedfor other organelles and whole living cells. Sani, M.-A., Keech,O., Gardeström, P., Dufourc, E. J., Gröbner, G. Magic-anglephosphorus NMR of functional mitochondria: in situ monitoringof lipid response under apoptotic-like stress.
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| 9. |
- Tassidis, Helena, et al.
(författare)
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Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer
- 2010
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 126:10, s. 2296-2307
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Tidskriftsartikel (refereegranskat)abstract
- The protein tyrosine kinase (PTK) receptors and cytosolic signaling proteins as well as the protein tyrosine phosphatases (PTPs) have important roles in regulation of growth of the benign and malignant prostate gland. Here, we studied expression of the protein tyrosine phosphatase SHP-1 in prostate cancer cell lines and in human prostatic tissues. SHP-1 is expressed at a high level in LNCaP prostate cancer cells compared with PC3 cells. Silencing of SHP-1 expression with siRNA in LNCaP cells led to an increased rate of proliferation, whereas overexpression of SHP-1 by means of transient and stable transfection in PC3 cells led to a decrease in proliferation. Corresponding changes were observed in cyclin D1 expression. We further demonstrate that LNCaP and PC3 cells respond differently to IL-6 stimulation. SHP-1 overexpression in PC3 cells reversed IL-6 stimulation of proliferation, whereas in SHP-1-silenced LNCaP cells, IL-6 inhibition of proliferation was not affected. In addition, IL-6 treatment led to higher levels of phosphorylated STAT3 in SHP-1-silenced LNCaP cells than in control cells. Next, SHP-1 expression in human prostate cancer was analyzed by immunohistochemical staining of tissue microarrays comprising tumor specimens from 100 prostate cancer patients. We found an inverse correlation between the tumor level of SHP-1 expression and time to biochemical recurrence and clinical progression among prostate cancer patients. In conclusion, our results suggest that a decreased level of SHP-1 expression in prostate cancer cells is associated with a high proliferation rate and an increased risk of recurrence or clinical progression after radical prostatectomy for localized prostate cancer.
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| 10. |
- Malyarenko, Anatoliy, 1957-, et al.
(författare)
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Spectral expansions of homogeneous and isotropic tensor-valued random fields
- 2016
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Ingår i: Zeitschrift für angewandte Matematik und Physik ZAMP. - Basel : Birkhäuser Verlag. - 0044-2275 .- 1420-9039. ; 67:3
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Tidskriftsartikel (refereegranskat)abstract
- We establish spectral expansions of tensor-valued homogeneous and isotropic random fields in terms of stochastic integrals with respect to orthogonal scattered random measures previously known only for the case of tensor rank 0. The fields under consideration take values in the 3-dimensional Euclidean space E3 and in the space S2(E3) of symmetric rank 2 tensors over E3. We find a link between the theory of random fields and the theory of finite-dimensional convex compact sets. These random fields furnish stepping-stone for models of rank 1 and rank 2 tensor-valued fields in continuum physics, such as displacement, velocity, stress, strain, providing appropriate conditions (such as the governing equation or positive-definiteness) are imposed.
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