| 1. |
|
|
| 2. |
|
|
| 3. |
- Vorobyeva, Anzhelika, et al.
(författare)
-
Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging
- 2019
-
Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 20:12
-
Tidskriftsartikel (refereegranskat)abstract
- Radionuclide molecular imaging of human epidermal growth factor receptor 2 (HER2) in breast and gastroesophageal cancer might be used to stratify patients for HER2-targeted therapy as well as monitor treatment response and disease progression. Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins with favorable properties for molecular imaging. Herein we compared two methods for labeling the anti-HER2 DARPin (HE)(3)-G3, direct and indirect radioiodination. We hypothesized that the use of N-succinimidyl-para-iodobenzoate (SPIB) for radioiodination would facilitate the clearance of radiometabolites and improve the contrast of imaging. Both radiolabeled (HE)(3)-G3 variants preserved their binding specificity and high affinity to HER2-expressing cells. The specificity of tumor targeting in vivo was also demonstrated. A biodistribution comparison of [I-125]I-(HE)(3)-G3 and [I-125]I-PIB-(HE)(3)-G3, in mice bearing HER2 expressing SKOV3 xenografts, showed rapid clearance of [I-125]I-PIB-(HE)(3)-G3 from normal organs and tissues and low accumulation of activity in organs with NaI-symporter expression. Both radiolabeled (HE)(3)-G3 variants had equal tumor uptake. Consequently, the indirect label provided higher tumor-to-blood and tumor-to-organ ratios compared with the direct label. Comparative Single Photon Emission Computed Tomography (SPECT)/CT imaging of HER2 expression in SKOV3 xenografts, using both radiolabeled DARPins, demonstrated the superior imaging contrast of the indirect label. Indirect radioiodination of (HE)(3)-G3 using SPIB could be further applied for SPECT and PET imaging with iodine-123 and iodine-124.
|
|
| 4. |
|
|
| 5. |
- Beach, Hugh
(författare)
-
Visit to a Siberian Sovkhoz
- 1986
-
Ingår i: Antropologiska Studier. ; :38-39
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 6. |
- Castañeda, Oscar, et al.
(författare)
-
Soft-Output Finite Alphabet Equalization for mmWave Massive MIMO
- 2020
-
Ingår i: ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings. - 1520-6149. ; 2020-May, s. 1764-1767
-
Konferensbidrag (refereegranskat)abstract
- Nxt-generation wireless systems are expected to combine millimeter-wave (mmWave) and massive multi-user multiple-input multiple-output (MU-MIMO) technologies to deliver high data-rates. These technologies require the basestations (BSs) to process high-dimensional data at extreme rates, which results in high power dissipation and system costs. Finite-alphabet equalization has been proposed recently to reduce the power consumption and silicon area of uplink spatial equalization circuitry at the BS by coarsely quantizing the equalization matrix. In this work, we improve upon finite-alphabet equalization by performing unbiased estimation and soft-output computation for coded systems. By simulating a massive MU-MIMO system that uses orthogonal frequency-division multiplexing and per-user convolutional coding, we show that soft-output finite-alphabet equalization delivers competitive error-rate performance using only 1 to 3 bits per entry of the equalization matrix, even for challenging mmWave channels.
|
|
| 7. |
|
|
| 8. |
- Sellén, Mikael, et al.
(författare)
-
SVÄRTNING I NYBYGGNATION - FÖRSTUDIE En litteraturstudie
- 2020
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Black Magic Dust - a Literature Study The spontaneous discoloration of indoor surfaces which occurs especially during the heating period has been intensively investigated in Sweden, Norway and Germany since the end of the 1970s. On the basis of earlier studies and this phenomenon, referred to as "spontan nedsvärtning" (sudden soiling, in Sweden), "Hekesot" (in Norway), "‘black dwellings’ or ‘black magic dust’ (BMD), was attributed to the presence of semi-volatile organic compounds (SVOCs) and their interaction with dust and particles. This report is an atempt to display litterature available today regardning the scientific knowledge so far.
|
|
