| 1. |
- Gidlöf, Olof, et al.
(författare)
-
Cardiospecific microRNA Plasma Levels Correlate with Troponin and Cardiac Function in Patients with ST Elevation Myocardial Infarction, Are Selectively Dependent on Renal Elimination, and Can Be Detected in Urine Samples.
- 2011
-
Ingår i: Cardiology. - : S. Karger AG. - 1421-9751 .- 0008-6312. ; 118:4, s. 217-226
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: Circulating microRNAs (miRNAs) are promising as biomarkers for various diseases. We examined the release patterns of cardiospecific miRNAs in a closed-chest, large animal ischemia-reperfusion model and in patients with ST elevation myocardial infarction (STEMI). Methods: Six anesthetized pigs were subjected to coronary occlusion-reperfusion. Plasma, urine, and clinical parameters were collected from 25 STEMI patients undergoing primary percutaneous coronary intervention. miRNA was extracted and measured with qPCR. Results: In the pig reperfusion model miR-1, miR-133a, and miR-208b increased rapidly in plasma with a peak at 120 min, while miR-499-5p remained elevated longer. In patients with STEMI all 4 miRNAs increased abruptly from 70-fold to 3,000-fold in plasma, with a peak within 12 h (p < 0.01). miR-1 and miR-133a both correlated strongly with the glomerular filtration rate (GFR), indicating renal elimination. This was confirmed by detection of miR-1 and miR-133a, but not miR-208b or miR-499-5p, in urine. Peak values of miR-208b correlated with peak troponin and the ejection fraction. Conclusion: We demonstrate a distinct and rapid increase in levels of cardiospecific miRNA in the circulation after myocardial infarction. Release of miRNAs correlated with cardiomyocyte necrosis markers, the ejection fraction, and the GFR, indicating a possible role for these molecules as biomarkers for the diagnosis of STEMI as well as the prediction of long-term complications.
|
|
| 2. |
- Frostlund, Jörgen, et al.
(författare)
-
Evidence-based teaching in Swedish compulsory schools for pupils with intellectual disabilities
- 2023
-
Ingår i: Journal of Interactional Research in Communication Disorders. - : Equinox Publishing Ltd.. - 2040-512X .- 2040-5111. ; 14:1, s. 154-188
-
Tidskriftsartikel (refereegranskat)abstract
- Background: This study aims to identify the evidence-based teaching programs regarding communication and interaction that underpin Swedish compulsory schools for pupils with intellectual disabilities (ID).Method: This quantitative census survey fills a gap in the existing research literature, in that all qualified teachers in the schools report on the use of evidence-based teaching programs regarding communication and interaction for pupils with ID.Results: Only a small proportion of the teachers received any formal teacher training on evidence-based teaching programs or participated in any continuing professional development (CPD) on these programs. We also evidenced a teaching gap among Swedish special schools, as commonly used teaching programs differ within Swedish compulsory schools for pupils with ID. In addition, some commonly used teaching programs do not always promote interaction and learning for pupils.Discussion/conclusion: The teaching profession is in need of scientific guidance, in order to create evidence-based teaching practice for pupils with ID, which should be a focus of future studies.
|
|
| 3. |
|
|
| 4. |
- Kaufman, M., et al.
(författare)
-
Observations of the Ocular Galaxy NGC 2535 and its Starburst Companion NGC 2536
- 1997
-
Ingår i: Astronomical Journal. - : American Astronomical Society. - 1538-3881 .- 0004-6256. ; 114, s. 2323-2349
-
Tidskriftsartikel (refereegranskat)abstract
- H I, radio continuum, and 12CO J=1-->0 observations at resolutions of 12" to 33" (=2.9-8 kpc), and B, I, J, and K-band images, are presented of the galaxy NGC 2535 and its small starburst companion NGC 2536. NGC 2535 has an ocular (eye-shaped) structure with two long tidal arms indicative of a recent, close, nonmerging encounter. Our observations reveal widespread high velocity dispersions (30 km s-1) in the H I gas and five clouds with masses of ˜10^8 Msun in the tidal arms of NGC 2535. These clouds do not correspond to the most luminous blue knots or to major clumps in the old stellar population. Similar phenomena were found previously in other pairs (IC 2163/NGC 2207 and NGC 5774/5), suggesting that enhanced turbulence and massive gas clouds may be a general feature of interacting spiral galaxies during an early phase of post-encounter evolution. A search for 12CO J= 1-->O emission at 11 positions in NGC 2535 and one position in NGC 2536 yielded two clear detections, one at the center of NGC 2535 and the other on its tidal tail but close to the center of NGC 2535. Most of the massive H I clouds in NGC 2535 are not detected in CO emission. The virial masses of these clouds are significantly greater than their measured masses in gas, presumably because of the presence of old disk stars in the clouds. A form of the virial theorem that includes gas and stars is presented. NGC 2535 shows several unusual features, including an intrinsically oval shape to the disk, that are similar to those in the ocular galaxy IC 2163 studied previously. NGC 2535 also contains structures that are not seen in IC 2163. For example, there is an extended (R =48 kpc) H I envelope and a long, outer, elliptically-shaped H I arc in NGC 2535 that may be a gravitational wake produced by the passage of the companion within or close to the envelope. In the radio continuum, NGC 2535 exhibits a bar-like feature that leads the small stellar bar by 50°. The starburst companion, NGC 2536, lies in a 2 X 10^9 Msun clump of H I gas at the outer end of the tidal bridge from NGC 2535. Most of the gas in this clump is associated with the bridge. The H I emission on the anticompanion side of NGC 2536 has the same line-of-sight velocity and projected position as some of the bridge gas there. This observation is consistent with a previous model by Klaric in which NGC 2536 accretes gas from NGC 2535; we even find an H I feature that may represent bridge gas streaming towards NGC 2536. The failure to detect 12CO emission in NGC 2536 places an upper limit of 6 X H2 on its H2 mass if the standard value of the conversion factor between I_CO and N(H2) applies.
|
|
| 5. |
|
|
