| 1. |
- Wilander, Erik, et al.
(författare)
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Diagnostic criteria of classical carcinoids
- 1991
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 30:4, s. 469-475
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Tidskriftsartikel (refereegranskat)abstract
- The classical (mid-gut) carcinoids of the intestinal tract display a characteristic light microscopic morphology. However, sometimes intestinal tumours are seen resembling carcinoids and differential diagnostic difficulties arise. In the present study silver stains and immunoreactivities to chromogranin A + B, cytokeratins and epithelial membrane antigen (EMA) were evaluated as diagnostic adjuncts in six classical carcinoids and six intestinal carcinomas with carcinoid-like features. All classical carcinoids were argentaffin and argyrophil and contained a majority cell population with chromogranin immunoreactivity while only one carcinoid-like carcinoma was chromogranin-immunoreactive and the stained cells in that case represented a minority of the tumour cell population. The cytokeratins were shown to be non-discriminatory. However, EMA expression occurred in five intestinal carcinomas and in the majority of the tumour cells of four of these cases, while only one classical carcinoid displayed a few EMA positive cells. Thus, silver stains in combination with chromogranin A + B and EMA appears to be of value to discriminate between classical carcinoids and carcinoid-like intestinal carcinomas. Further when intestinal carcinoids and carcinoid-like carcinomas are diagnosed with the aid of various tumour markers both qualitative and quantitative considerations must be made.
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| 2. |
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| 3. |
- Krispinsson, Charlotta, Dr. 1984-
(författare)
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The true image
- 2018
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Ingår i: Kunsthistorisk Bogliste. - : Dansk Kunsthistoriker Forening. - 2245-0092. ; :14
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Recension (övrigt vetenskapligt/konstnärligt)
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| 4. |
- McKinlay, Audrey, et al.
(författare)
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Service provision for children and young people with acquired brain injury : Practice recommendations
- 2016
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Ingår i: Brain Injury. - : Informa UK Limited. - 0269-9052 .- 1362-301X. ; 30:13-14, s. 1656-1664
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Tidskriftsartikel (refereegranskat)abstract
- Background: Providing appropriate rehabilitation services for Acquired Brain Injury (ABI) in childhood presents a number of challenges for caregivers, health and education professionals and the young person as they develop. Primary objective: To record the challenges and possible creative solutions generated by an international group of professionals to address the needs of children with ABI. Review of information: Recommendations were generated from children's special interest group meetings of the International Brain Injury Association (Turin, Italy, 2001; Stockholm, Sweden, 2003; Melbourne, Australia, 2005; Lisbon, Portugal, 2008) and through meetings of the International Paediatric Brain Injury Society (IPBIS), formed in 2009. Delegates participating in the workshops were representative of nations from around the world and included The Netherlands, New Zealand, Australia, the UK, Finland, Germany, South Africa, the US, Canada, Sweden, Brazil and Italy. Outcomes: The information presented is based on a retrospective review of those meetings and the summaries of the topics considered.
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| 5. |
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| 6. |
- Vardi, Anna, et al.
(författare)
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Immunogenetic Studies of Chronic Lymphocytic Leukemia : Revelations and Speculations about Ontogeny and Clinical Evolution
- 2014
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 74:16, s. 4211-4216
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Forskningsöversikt (refereegranskat)abstract
- Over the last decade, immunogenetic analysis of B-cell receptor immunoglobulins (BcR IG) has proved instrumental in dissecting chronic lymphocytic leukemia (CLL) pathogenesis. Initially, it was the finding that the level of somatic hypermutations in rearranged IG heavy-chain genes could define two CLL subtypes associated with a different clinical course that drew attention. As the years ensued, this not only continued to hold strong, but also revealed an unprecedented BcR restriction (aptly coined as "stereotypy"), thus cementing the idea that antigenic elements select the leukemic clones. With all this in mind, in the present review, we focus on the CLL BcR IG, a molecule that clearly lies at the heart of disease pathogenesis, and attempt to distil from past and emerging biologic knowledge the most relevant aspects in the context of the immunogenetics of CLL, while at the same time provoking questions that remain unanswered. We juxtapose CLL with mutated BcR IGs against CLL with unmutated BcR IGs due to their striking clinicobiologic differences; however, when considering ontogeny, common derivation of the two mutational subtypes cannot be excluded. The issue of stereotypy is intertwined throughout and we also raise the subject of isotype-switched CLL, which, despite its rarity, contributes intriguing ontogenetic hints.
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