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- 2019
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Haycock, Philip C., et al.
(författare)
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Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
- 2017
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Ingår i: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 3:5, s. 636-651
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
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| 4. |
- Chen, Min, et al.
(författare)
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Highly stable and efficient all-inorganic lead-free perovskite solar cells with native-oxide passivation
- 2019
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- There has been an urgent need to eliminate toxic lead from the prevailing halide perovskite solar cells (PSCs), but the current lead-free PSCs are still plagued with the critical issues of low efficiency and poor stability. This is primarily due to their inadequate photovoltaic properties and chemical stability. Herein we demonstrate the use of the lead-free, all-inorganic cesium tin-germanium triiodide (CsSn(0.5)Ge(0.5)l(3)) solid-solution perovskite as the light absorber in PSCs, delivering promising efficiency of up to 7.11%. More importantly, these PSCs show very high stability, with less than 10% decay in efficiency after 500 h of continuous operation in N-2 atmosphere under one-sun illumination. The key to this striking performance of these PSCs is the formation of a full-coverage, stable native-oxide layer, which fully encapsulates and passivates the perovskite surfaces. The native-oxide passivation approach reported here represents an alternate avenue for boosting the efficiency and stability of lead-free PSCs.
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- Chen, Zhibin, et al.
(författare)
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Summary of the 3rd International Workshop on Gas-Dynamic Trap based Fusion Neutron Source (GDT-FNS)
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:6
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Tidskriftsartikel (refereegranskat)abstract
- The 3rd International Workshop on Gas-Dynamic Trap-based Fusion Neutron Source (GDT-FNS) was held through the hybrid mode on 13-14 September 2021 in Hefei, China, jointly organized by the Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Sciences (CAS), and the Budker Institute of Nuclear Physics (BINP), Russian Academy of Sciences (RAS). It followed the 1st GDT-FNS Workshop held in November 2018 in Hefei, China, and the 2nd taking place in November 2019 in Novosibirsk, Russian Federation. With the financial support from CAS and China Association for Science and Technology (CAST), this workshop was attended by more than 80 participants representing 20 institutes and universities from seven countries, with oral presentations broadcast via the Zoom conferencing system. Twenty-two presentations were made with topics covering design and key technologies, simulation and experiments, steady-state operation, status of the ALIANCE project, multi applications of neutron sources, and other concepts (Tokamaks, Mirrors, FRC, Plasma Focus, etc). The workshop consensus was made including the establishment of the ALIANCE International Working Group. The next GDT-FNS workshop is planned to be held in May 2022 in Novosibirsk.
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| 6. |
- Christian, Parul, et al.
(författare)
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Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries
- 2013
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 42:5, s. 1340-1355
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:Low- and middle-income countries continue to experience a large burden of stunting; 148 million children were estimated to be stunted, around 30-40% of all children in 2011. In many of these countries, foetal growth restriction (FGR) is common, as is subsequent growth faltering in the first 2 years. Although there is agreement that stunting involves both prenatal and postnatal growth failure, the extent to which FGR contributes to stunting and other indicators of nutritional status is uncertain.METHODS:Using extant longitudinal birth cohorts (n = 19) with data on birthweight, gestational age and child anthropometry (12-60 months), we estimated study-specific and pooled risk estimates of stunting, wasting and underweight by small-for-gestational age (SGA) and preterm birth.RESULTS:We grouped children according to four combinations of SGA and gestational age: adequate size-for-gestational age (AGA) and preterm; SGA and term; SGA and preterm; and AGA and term (the reference group). Relative to AGA and term, the OR (95% confidence interval) for stunting associated with AGA and preterm, SGA and term, and SGA and preterm was 1.93 (1.71, 2.18), 2.43 (2.22, 2.66) and 4.51 (3.42, 5.93), respectively. A similar magnitude of risk was also observed for wasting and underweight. Low birthweight was associated with 2.5-3.5-fold higher odds of wasting, stunting and underweight. The population attributable risk for overall SGA for outcomes of childhood stunting and wasting was 20% and 30%, respectively.CONCLUSIONS:This analysis estimates that childhood undernutrition may have its origins in the foetal period, suggesting a need to intervene early, ideally during pregnancy, with interventions known to reduce FGR and preterm birth.
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| 7. |
- Denil, Joachim, et al.
(författare)
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Model-Driven Engineering Approaches to Design Space Exploration
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- During the design and deployment of increasingly complex distributed embedded systems, engineers are challenged by a plethora of design choices. This often results in infeasible or sub-optimal solutions. In industry and academia, general and domain-specific optimization techniques are developed to explore the tradeoffs within these design spaces, though these techniques are usually not adapted for use within a Model- Driven Engineering (MDE) process. In this paper we propose to encode metaheuristics in transformation models as a general design exploration method. This is complemented by an MDE framework for combining different heterogeneous techniques at different abstraction layers using model transformations. Our approach results in the seamless integration of design space exploration in the MDE process. The proposed methods are applied on the deployment of an automotive embedded system, yielding a set of Pareto-optimal solutions.
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| 8. |
- Geng, Xiongfei, et al.
(författare)
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Exploring High-energy Emission from the BL Lacertae Object S5 0716+714 with the Fermi Large Area Telescope
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 904:1
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of an extensive gamma-ray data analysis of the emission from the blazar S5 0716+714 with the primary motivation to study its temporal and spectral variability behavior. In this work, we extract a 10 days binned gamma-ray light curve from 2008 August 4 to 2016 April 27 in the energy range of 0.1-300 GeV and identify six outburst periods with peak flux of >4 x 10(-7) ph cm(-2) s(-1) from this highly variable source. The brightest flares are identified by zooming in these outburst periods to 1 day binning and using the Bayesian Blocks algorithm. The fastest variability timescale is found to be 1.5 0.3 hr at MJD 57128.01 0.01 with a peak flux above 100 MeV of (26.8 6.9) x 10(-7) ph cm(-2) s(-1). No hint of periodic modulations has been detected for the light curve of S5 0716+714. During the outburst phases, the gamma-ray spectrum shows an obvious spectral break with a break energy between 0.93 and 6.90 GeV energies, which may be caused by an intrinsic break in the energy distribution of radiating particles. The five highest-energy photons, with E > 100 GeV, imply that the high-energy emission from this source may originate from a moving emission region in a helical path upstream in the jet. The spectral behavior and temporal characteristics of the individual flares indicate that the location of the emission region lies in the sub-parsec scale (r(gamma) < 0.85 pc).
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| 9. |
- Gu, Jitai, et al.
(författare)
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Interdecadal variations in the interannual relationship between winter tropical Pacific SST and subsequent summer Arctic sea ice in early 2000s
- 2024
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Ingår i: International Journal of Climatology. - 0899-8418 .- 1097-0088.
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Tidskriftsartikel (refereegranskat)abstract
- The present study investigates the interdecadal change in the interannual relationship between winter sea surface temperature (SST) in the tropical central-eastern Pacific and the subsequent summer Arctic sea ice concentration (SIC) and its possible mechanism using 1979–2023 monthly SST and SIC data from Hadley Center and atmospheric reanalysis data from NCEP/NCAR. It is found that the relationship between the winter tropical Pacific SST and the subsequent summer SIC of Beaufort Sea experienced an obvious interdecadal change from a significant negative correlation to a weak and insignificant correlation before and after the early 2000s, respectively. Before the early 2000s, when winter SST warming (cooling) anomalies occurred in the central and eastern tropical Pacific, it could sustain into summer and enhance a Rossby wave propagating from Tropic to high latitude, forming negative (positive) pressure anomalies in the North Pacific. Influenced by such anomalies, it is conducive to maintaining negative (positive) SST anomalies in the North Pacific from winter to subsequent summer. The summer SST cooling (warming) in the North Pacific could form a favourable atmospheric circulation anomaly for less (more) SIC. In contrast, after the early 21st century, the strong SST anomalies in winter over the eastern tropical Pacific would weaken with time and subsequently diminish in spring, leading to the SST anomalies in the North Pacific persist to spring, which can hardly affect summer SIC anomaly in the Beaufort Sea. Therefore, the relationship collapses after the the early 2000s due to the weakened persistence of the eastern tropical Pacific SST anomaly.
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| 10. |
- Iyakaremye, Vedaste, et al.
(författare)
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Increased high-temperature extremes and associated population exposure in Africa by the mid-21st century
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 790
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies warned that heat extremes are likely to intensify and frequently occur in the future due to climate change. Apart from changing climate, the population's size and distribution contribute to the total changes in the population exposed to heat extremes. The present study uses the ensemble mean of global climate models from the Coupled Model Inter-comparison Project Phase six (CMIP6) and population projection to assess the future changes in high-temperature extremes and exposure to the population by the middle of this century (2041–2060) in Africa compared to the recent climate taken from 1991 to 2010. Two Shared Socioeconomic Pathways (SSPs), namely SSP2-4.5 and SSP5-8.5, are used. Changes in population exposure and its contributors are quantified at continental and for various sub-regions. The intensity of high-temperature extremes is anticipated to escalate between 0.25 to 1.8 °C and 0.6 to 4 °C under SSP2-4.5 and SSP5-8.5, respectively, with Sahara and West Southern Africa projected to warm faster than the rest of the regions. On average, warm days' frequency is also expected to upsurge under SSP2-4.5 (26–59%) and SSP5-8.5 (30–69%) relative to the recent climate. By the mid-21st century, continental population exposure is expected to upsurge by ~25% (28%) of the reference period under SSP2-4.5|SSP2 (SSP5-8.5|SSP5). The highest increase in exposure is expected in most parts of West Africa (WAF), followed by East Africa. The projected changes in continental exposure (~353.6 million person-days under SSP2-4.5|SSP2 and ~401.4 million person-days under SSP5-8.5|SSP5) are mainly due to the interaction effect. However, the climate's influence is more than the population, especially for WAF, South-East Africa and East Southern Africa. The study findings are vital for climate change adaptation.
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