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  • Hsieh, Yves S. Y., et al. (author)
  • Total synthesis of homogeneous variants of hirudin P6 : a post-translationally modified anti-thrombotic leech-derived protein
  • 2014
  • In: Angewandte Chemie International Edition. - : Wiley-VCH Verlagsgesellschaft. - 1433-7851 .- 1521-3773. ; 53:15, s. 3947-51
  • Journal article (peer-reviewed)abstract
    • Hirudin P6 is a leech-derived anti-thrombotic protein which possesses two post-translational modifications, O-glycosylation and tyrosine sulfation. In this study we report the ligation-based synthesis of a library of hirudin P6 proteins possessing homogeneous glycosylation and sulfation modifications. The nature of the modifications incorporated was shown to have a drastic effect on inhibition against both the fibrinogenolytic and amidolytic activities of thrombin and thus highlights a potential means for attenuating the biological activity of the protein.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Payne, Richard J. (1)
Hsieh, Yves S. Y. (1)
Pike, Robert N. (1)
Wijeyewickrema, Laks ... (1)
Wilkinson, Brendan L ... (1)
University
Royal Institute of Technology (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2014 (1)

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