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- Grebenkov, Denis, et al.
(författare)
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Exploring diffusion across permeable barriers at high gradients. I. Narrow pulse approximation
- 2014
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Ingår i: Journal of magnetic resonance. - : Elsevier BV. - 1090-7807 .- 1096-0856. ; 248, s. 153-163
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Tidskriftsartikel (refereegranskat)abstract
- The adaptive variation of the gradient intensity with the diffusion time at a constant optimal b-value is proposed to enhance the contribution of the nuclei diffusing across permeable barriers, to the pulsed-gradient spin-echo (PGSE) signal. An exact simple formula the PGSE signal is derived under the narrow pulse approximation in the case of one-dimensional diffusion across a single permeable barrier. The barrier contribution to the signal is shown to be maximal at a particular b-value. The exact formula is then extended to multiple permeable barriers, while the PGSE signal is shown to be sensitive to the permeability and to the inter-barrier distance. Potential applications of the protocol to survey diffusion in three-dimensional domains with permeable membranes are illustrated through numerical simulations.
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