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  • Westermark, Pål, et al. (author)
  • Derivation of a reversible Hill equation with modifiers affecting catalytic properties
  • 2004
  • In: WSEAS Transactions on Biology and Biomedicine. - 1109-9518 .- 2224-2902. ; 1, s. 91-98
  • Journal article (peer-reviewed)abstract
    • An existing generic enzyme rate equation, the reversible Hill equation, was generalized to account for modifiers affecting the catalytical properties of the enzyme as well as for the case of several substrates and products. The resulting generalized reversible Hill (GRH) equation has relatively few but operationally well-defined parameters. Its usefulness is demonstrated by fitting it to experimental data on mammalian muscle phosphofructokinase. The fit is superior to that of previous models to the same data. The rate equation derived is suitable for replacing more complicated rate equations when exact mechanisms are unknown and data is scarce or contradictory.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Hällgren Kotaleski, ... (1)
Lansner, Anders (1)
Westermark, Pål (1)
University
Royal Institute of Technology (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2004 (1)

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