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- Ibrahem, Ismail, et al.
(författare)
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Enantioselective Organocatalytic Hydrophosphination of α,β-Unsaturated Aldehydes
- 2007
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 46:24, s. 4507-4510
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Tidskriftsartikel (refereegranskat)abstract
- Keeping it simple: Optically active phosphine derivatives can be obtained in high yields and in up to 99% ee by using simple chiral amines to catalyze the hydrophosphination of α,β-unsaturated aldehydes (see scheme, green sphere = chiral group). The synthetic utility of this highly chemo- and enantioselective transformation was exemplified by the one-pot asymmetric synthesis of β-phosphine oxide acids.
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