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  • Carlsson, Jenny, 1977-, et al. (author)
  • An indirect competitive immunoassay for insulin autoantibodies based on surface plasmon resonance
  • 2008
  • In: Biosensors and Bioelectronics. - : Elsevier BV. - 0956-5663. ; 24:4, s. 876-881
  • Journal article (peer-reviewed)abstract
    • We have developed a sensitive and specific method based on surface plasmon resonance (SPR) for detection of insulin autoantibodies (IAA) in serum samples from individuals at high risk of developing type 1 diabetes (T1D). When measuring trace molecules in undiluted sera with label-free techniques like SPR, non-specific adsorption of matrix proteins to the sensor surface is often a problem, since it causes a signal that masks the analyte response. The developed method is an indirect competitive immunoassay designed to overcome these problems. Today, IAA is mainly measured in radio immunoassays (RIAs), which are time consuming and require radioactively labeled antigen. With our SPR-based immunoassay the overall assay time is reduced by a factor of >100 (4 days to 50 min), while sensitivity is maintained at a level comparable to that offered by RIA.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Ludvigsson, Johnny (1)
Liedberg, Bo (1)
Enander, Karin (1)
Westermark, Gunilla (1)
Carlsson, Jenny, 197 ... (1)
Gullstrand, Camilla (1)
University
Linköping University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2008 (1)

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