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  • Sandgren, Veronica, et al. (author)
  • Design and synthesis of hydroxyethylene-based BACE-1 inhibitors incorporating extended P1 substituents
  • 2013
  • In: Open Medicinal Chemistry Journal. - Bussum, Netherlands : Bentham Open. - 1874-1045. ; 7, s. 1-15
  • Journal article (peer-reviewed)abstract
    • Novel BACE-1 inhibitors with a hydroxyethylene central core have been  developed. Modified P1´ and extended P1 substituents were incorporated with the aim to explore potential interactions with the S1´ and the S1-S3 pocket, respectively, of BACE-1. Inhibitors were identified displaying IC50 values in the nanomolar range, i.e., 69 nM for the most potent compound. Possible inhibitor interactions with the enzyme are also discussed.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Kvarnström, Ingemar (1)
Bäck, Marcus (1)
Sandgren, Veronica (1)
Dahlgren, Anders (1)
University
Linköping University (1)
Language
English (1)
Year
2013 (1)

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