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  • Hillefors, M., et al. (author)
  • Prominent binding of the dopamine D3 agonist [3H]PD 128907 in the caudate-putamen of the adult rat
  • 1999
  • In: Brain Research. - : Elsevier. - 0006-8993 .- 1872-6240. ; 822:1-2, s. 126-131
  • Journal article (peer-reviewed)abstract
    • We have analyzed the binding properties of the selective D3 receptor agonist [3H]PD 128907 in 120 days old rats. In tissue sections, we found high numbers of binding sites for [3H]PD 128907 both in the islands of Calleja and the caudate-putamen (Bmax values being 500 and 1000 fmol/mg protein, respectively). The KD values were higher in the caudate-putamen than in the islands of Calleja. Similar regional differences in Bmax and KD values were observed in membranes from the caudate-putamen and the subcortical limbic region. The distribution of [3H]PD 128907 in adult rats is markedly different from that observed in young rats. Taken together, the present results suggest a prominent presence of D3 receptors in the caudate-putamen of adult, but not young, rats. Hence, these findings may have important physiological, pathophysiological, and clinical implications.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
von Euler, Mia, 1967 ... (1)
von Euler, G (1)
Hillefors, M (1)
Hedlund, P. B. (1)
University
Örebro University (1)
Karolinska Institutet (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
1999 (1)

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