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  • Lindner, Karl-Johan, et al. (author)
  • Analysis of l-[methyl-11C]methionine and metabolites in human plasma by an automated solid-phase extraction and a high-performance liquid chromatographic procedure
  • 1996
  • In: Journal of Chromatography B. - : Elsevier BV. - 1387-2273 .- 1878-5603. ; 679:1-2, s. 13-19
  • Journal article (peer-reviewed)abstract
    • A fully automated method for separation of l-[methyl-11C]Methionine from metabolites in patient plasma was developed. l-[methyl-11C]Methionine was isolated from plasma by solid-phase extraction (SPE). The radioactivity retained on the SPE column was eluted and injected onto the HPLC system for separation of in vivo formed l-[methyl-11C]methionine radiolabeled metabolites. The yield through the isolation procedure and HPLC analysis was greater than 95% with a precision better than 5% (R.S.D.). The calculated rate of l-[methyl-11C]methionine transport into tumor tissue was markedly different with and without compensation for radiolabeled metabolises in patient plasma.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Sundin, Anders (1)
Långström, Bengt (1)
Hartvig, Per (1)
Tyrefors, Niklas (1)
Lindner, Karl-Johan (1)
Åkesson, Christina (1)
University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year

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