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  • Hesslow, Germund, et al. (author)
  • Timing in Purkinje Cells and a Novel Learning Mechanism
  • 2021
  • In: Contemporary Clinical Neuroscience. - Cham : Springer International Publishing. - 2627-535X .- 2627-5341. - 9783030758165 - 9783030758172 ; , s. 327-335
  • Book chapter (peer-reviewed)abstract
    • During eyeblink conditioning, Purkinje cells that control the eyelid learn to respond with a pause in simple spike firing to the conditional stimulus. This conditional pause response (CR) in the Purkinje cell is adaptively timed and drives the overt response. Recent results show that the Purkinje cell CR does not depend on modification of synaptic strength such as long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and to time of the CR accordingly. The Purkinje cell CR is elicited by glutamate acting on metabotropic receptors (mGluR7) and may involve inwardly rectifying potassium channels (Kir3).
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Type of publication
book chapter (1)
Type of content
peer-reviewed (1)
Author/Editor
Johansson, Fredrik (1)
Hesslow, Germund (1)
Jirenhed, Dan-Anders (1)
Mizusawa, Hidehiro (1)
Kakei, Shinji (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Engineering and Technology (1)
Year
2018 (1)

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