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  • Szalaj, Natalia, et al. (author)
  • Bacterial type I signal peptidase inhibitors-Optimized hits from nature
  • 2022
  • In: European Journal of Medicinal Chemistry. - : Elsevier. - 0223-5234 .- 1768-3254. ; 238
  • Journal article (peer-reviewed)abstract
    • The ever-increasing number of bacteria resistant to the currently available antibacterial agents is a great medical problem today, and new antibiotics with novel mechanisms of action are urgently needed. Among the validated antibacterial drug targets against which new classes of antibiotics might be directed is bacterial type I signal peptidase (SPase I), an essential part of the Tat and Sec secretory systems. SPase I is responsible for the hydrolysis of the N-terminal signal peptides from proteins secreted across the cytoplasmic membrane and plays a key role in bacterial viability and virulence. This review focuses on the antibacterial activity of natural and synthetic SPase I inhibitors reported to date, namely beta-lactams, lipopeptides, and arylomycins, but also an example of SPase I activator was presented.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Karlén, Anders (1)
Wieckowska, Anna (1)
Mowbray, Sherry L, 1 ... (1)
Benediktsdottir, And ... (1)
Szałaj, Natalia (1)
Rusin, Dominika (1)
University
Uppsala University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2022 (1)

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