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  • Jin, Tao, 1973, et al. (author)
  • Impact of short-term therapies with biologics on prothrombotic biomarkers in rheumatoid arthritis.
  • 2009
  • In: Clinical and experimental rheumatology. - 0392-856X. ; 27:3, s. 491-4
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: Imbalance of haemostasis in patients with rheumatoid arthritis (RA) contributes to future risk of cardiovascular diseases (CVD). Prothrombotic molecules, e.g. fibrinogen, D-dimer, and tPA are elevated in plasma of RA patients, being associated to CVD. There is no imformation about the influence of biological drugs, e.g. anti-CD20 and tumor necrosis factor (TNF) antibodies on these prothrombotic molecules. OBJECTIVE: To assess whether anti-TNF and anti-CD20 therapies modify the profiles of cardiovascular risk factors in patients with RA. METHODS: The expression of prothrombotic molecules in plasma was investigated in 10 RA patients before and after treatment with TNF-alpha antibodies and in another 12 RA patients before and after anti-CD20 treatment. RESULTS: Both anti-TNF and anti-CD20 infusions gave rise to clear clinical improvement. However, only anti-CD20 infusion significantly (p=0.05) reduced concentration of fibrinogen (p=0.05), D-dimer (p<0.001), as well as tPA levels (p<0.01). In contrast, in TNF antibody treated patients only tPA levels were significantly decreased following the treatment (p<0.05). CONCLUSIONS: Infusion of CD20 antibodies to the patients with active RA led to a clearly reduced plasma levels of predictors of CVD indicating that this treatment, apart from its anti-inflammatory properties, may reduce the risk for future CVD in RA.
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Type of publication
journal article (1)
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peer-reviewed (1)
Author/Editor
Bokarewa, Maria, 196 ... (1)
Tarkowski, Andrej, 1 ... (1)
Jin, Tao, 1973 (1)
Amu, Sylvie, 1978 (1)
University
University of Gothenburg (1)
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English (1)
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