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  • Engstrand, Thomas, et al. (author)
  • Bioceramic Implant Induces Bone Healing of Cranial Defects.
  • 2015
  • In: Plastic and reconstructive surgery. Global open. - : LIPPINCOTT WILLIAMS & WILKINS. - 2169-7574. ; 3:8
  • Journal article (peer-reviewed)abstract
    • Autologous bone or inert alloplastic materials used in cranial reconstructions are techniques that are associated with resorption, infection, and implant exposure. As an alternative, a calcium phosphate-based implant was developed and previously shown to potentially stimulate bone growth. We here uncover evidence of induced bone formation in 2 patients. Histological examination 9 months postoperatively showed multinuclear cells in the central defect zone and bone ingrowth in the bone-implant border zone. An increased expression of bone-associated markers was detected. The other patient was investigated 50 months postoperatively. Histological examination revealed ceramic materials covered by vascularized compact bone. The bone regenerative effect induced by the implant may potentially improve long-term clinical outcome compared with conventional techniques, which needs to be verified in a clinical study.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Engqvist, Håkan (1)
Thomsen, Peter, 1953 (1)
Trobos, Margarita, 1 ... (1)
Engstrand, Thomas (1)
Kihlström, Lars (1)
Lundgren, Kalle (1)
University
University of Gothenburg (1)
Uppsala University (1)
Karolinska Institutet (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2015 (1)

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