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  • Pett, C., et al. (author)
  • Effective Assignment of alpha 2,3/alpha 2,6-Sialic Acid Isomers by LC-MS/MS-Based Glycoproteomics
  • 2018
  • In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 57:30, s. 9320-9324
  • Journal article (peer-reviewed)abstract
    • Distinct structural changes of the alpha 2,3/alpha 2,6-sialic acid glycosidic linkages on glycoproteins are of importance in cancer biology, inflammatory diseases, and virus tropism. Current glycoproteomic methodologies are, however, not amenable toward high-throughput characterization of sialic acid isomers. To enable such assignments, a mass spectrometry method utilizing synthetic model glycopeptides for the analysis of oxonium ion intensity ratios was developed. This method was successfully applied in large-scale glycoproteomics, thus allowing the site-specific structural characterization of sialic acid isomers.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Nilsson, J. (1)
Sihlbom, Carina, 197 ... (1)
Larson, G (1)
Olsson, Britt-Marie (1)
Nasir, W. (1)
Pett, C. (1)
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Caixeta, V. (1)
Schorlemer, M. (1)
Zahedi, R. P. (1)
Westerlind, U. (1)
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University
University of Gothenburg (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2018 (1)

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