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- Ahmadpour, Doryaneh, 1973, et al.
(författare)
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How the COVID-19 Overcomes the Battle? An Approach to Virus Structure
- 2020
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Ingår i: Iranian Journal of Kidney Diseases. - 1735-8582. ; 14:3, s. 167-172
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Forskningsöversikt (refereegranskat)abstract
- Coronaviruses primarily cause zoonotic infections, however in the past few decades several interspecies transmissions have occurred, the last one by SARS-CoV-2, causing COVID-19 pandemic, posing serious threat to global health. The SARS-CoV-2 spike (S) protein plays an important role in viral attachment, fusion and entry. However, other structural and non-structural SARS-CoV-2 proteins are potential influencers in virus pathogenicity. Among these proteins; Orf3, Orf8, and Orf10 show the least homology to SARS-CoV proteins and therefore should be further studied for their abilities to modulate antiviral and inflammatory responses. Here, we discuss how SARS-COV-2 interacts with our immune system.
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