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- Holdfeldt, André, et al.
(författare)
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Data showing effects of a PI3K-delta inhibitor on neutrophil superoxide production during FPR2 activation and reactivation
- 2020
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Ingår i: Data in Brief. - : Elsevier BV. - 2352-3409. ; 32
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Tidskriftsartikel (refereegranskat)abstract
- Reactive oxygen species (ROS) generated by the NADPH oxidase are crucial for antimicrobial host defense and also play a role in the regulation of inflammatory processes. Signals generated by formyl peptide receptor 2 (FPR2) activate the neutrophil ROS generating NADPH oxidase; such signals are mediated when the receptors bind an activating agonist, as well as when agonist desensitized FPR2 are reactivated by the receptor for platelet-activating factor (PAF). We present data on the effects of Idelalisib, a specific inhibitor for the PI3K delta isoform, on ROS production during FPR2 activation and reactivation by PAF, respectively. Neutrophils were isolated from peripheral blood of healthy adults obtained from the blood bank at Sahlgrenska University Hospital and ROS release was measured using isoluminol-amplified chemiluminescence. (C) 2020 The Authors. Published by Elsevier Inc.
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