SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "id:"swepub:oai:gup.ub.gu.se/325670" "

Sökning: id:"swepub:oai:gup.ub.gu.se/325670"

  • Resultat 1-1 av 1
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Redline, S., et al. (författare)
  • Obstructive sleep apnoea heterogeneity and cardiovascular disease
  • 2023
  • Ingår i: Nature Reviews Cardiology. - : Springer Science and Business Media LLC. - 1759-5002 .- 1759-5010. ; 20, s. 560-573
  • Forskningsöversikt (refereegranskat)abstract
    • In this Review, Redline and colleagues summarize our understanding of the shared risk factors and causal links between obstructive sleep apnoea (OSA) and cardiovascular disease and emerging knowledge on the heterogeneity of OSA. They also explore the potential role of new biomarkers for cardiovascular risk stratification in patients with OSA. Obstructive sleep apnoea (OSA), characterized by recurrent periods of upper airway obstruction and intermittent hypoxaemia, is prevalent in patients with cardiovascular disease (CVD), and is therefore important to consider in the prevention and management of CVD. Observational studies indicate that OSA is a risk factor for incident hypertension, poorly controlled blood pressure, stroke, myocardial infarction, heart failure, cardiac arrhythmias, sudden cardiac death and all-cause death. However, clinical trials have not provided consistent evidence that treatment with continuous positive airway pressure (CPAP) improves cardiovascular outcomes. These overall null findings might be explained by limitations in trial design and low levels of adherence to CPAP. Studies have also been limited by the failure to consider OSA as a heterogeneous disorder that consists of multiple subtypes resulting from variable contributions from anatomical, physiological, inflammatory and obesity-related risk factors, and resulting in different physiological disturbances. Novel markers of sleep apnoea-associated hypoxic burden and cardiac autonomic response have emerged as predictors of OSA-related susceptibility to adverse health outcomes and treatment response. In this Review, we summarize our understanding of the shared risk factors and causal links between OSA and CVD and emerging knowledge on the heterogeneity of OSA. We discuss the varied mechanistic pathways that result in CVD that also vary across subgroups of OSA, as well as the potential role of new biomarkers for CVD risk stratification.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-1 av 1
Typ av publikation
forskningsöversikt (1)
Typ av innehåll
refereegranskat (1)
Författare/redaktör
Peker, Yüksel, 1961 (1)
Azarbarzin, A. (1)
Redline, S. (1)
Lärosäte
Göteborgs universitet (1)
Lunds universitet (1)
Språk
Engelska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (1)
År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy