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  • Olofsson, Sven-Olof, 1947, et al. (author)
  • Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis
  • 2005
  • In: J Intern Med. - : Wiley. - 0954-6820. ; 258:5, s. 395-410
  • Journal article (peer-reviewed)abstract
    • Apolipoprotein (apo) B exists in two forms apoB100 and apoB48. ApoB100 is present on very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and LDL. ApoB100 assembles VLDL particles in the liver. This process starts by the formation of a pre-VLDL, which is retained in the cell unless converted to the triglyceride-poor VLDL2. VLDL2 is secreted or converted to VLDL1 by a bulk lipidation in the Golgi apparatus. ApoB100 has a central role in the development of atherosclerosis. Two proteoglycan-binding sequences in apoB100 have been identified, which are important for retaining the lipoprotein in the intima of the artery. Retention is essential for the development of the atherosclerotic lesion.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Olofsson, Sven-Olof, ... (1)
Borén, Jan, 1963 (1)
University
University of Gothenburg (1)
Language
English (1)
Year
2005 (1)

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