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  • Dam, J. S, et al. (author)
  • Fiber-optic probe for noninvasive real-time determination of tissue optical properties at multiple wavelengths
  • 2001
  • In: Applied Optics. - 2155-3165. ; 40:7, s. 1155-1164
  • Journal article (peer-reviewed)abstract
    • We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based on two-dimensional polynomial fitting are employed to extract and display the absorption and reduced scattering coefficients in real-time mode. The four wavelengths of the current configuration are 660, 785, 805, and 974 nm, respectively. Cross-validation tests on a 6 x 7 calibration matrix of Intralipid-dye phantoms showed that the mean prediction error at, e.g., 785 nm was 2.8% for the absorption coefficient and 1.3% for the reduced scattering coefficient. The errors are relative to the range of the optical properties of the phantoms at 785 nm, which were 0-0.3/cm for the absorption coefficient and 6-16/cm for the reduced scattering coefficient. Finally, we also present and discuss results from preliminary skin tissue measurements. (C) 2001 Optical Society of America
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Andersson-Engels, St ... (1)
Pedersen, C. B. (1)
Dam, J. S (1)
Dalgaard, T (1)
Fabricius, P. E (1)
Aruna, P (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
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