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  • Alkner, Sara, et al. (author)
  • Prior Adjuvant Tamoxifen Treatment in Breast Cancer Is Linked to Increased AIB1 and HER2 Expression in Metachronous Contralateral Breast Cancer.
  • 2016
  • In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:3
  • Journal article (peer-reviewed)abstract
    • The estrogen receptor coactivator Amplified in Breast Cancer 1 (AIB1) has been associated with an improved response to adjuvant tamoxifen in breast cancer, but also with endocrine treatment resistance. We hereby use metachronous contralateral breast cancer (CBC) developed despite prior adjuvant tamoxifen for the first tumor as an "in vivo"-model for tamoxifen resistance. AIB1-expression in the presumable resistant (CBC after prior tamoxifen) and naïve setting (CBC without prior tamoxifen) is compared and correlated to prognosis after CBC.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Fernö, Mårten (1)
Bendahl, Pär Ola (1)
Rydén, Lisa (1)
Ehinger, Anna (1)
Alkner, Sara (1)
Lövgren, Kristina (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2016 (1)

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