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  • Liu, Yingchun, et al. (author)
  • Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
  • 2007
  • In: Genome Biology. - : Springer Science and Business Media LLC. - 1474-7596 .- 1465-6906. ; 8:5
  • Journal article (peer-reviewed)abstract
    • Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation result in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Ringnér, Markus (1)
Liu, Yingchun (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2007 (1)

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