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- Adler, Belinda, et al.
(author)
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Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.
- 2012
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In: Electrophoresis. - : Wiley. - 0173-0835. ; 33:21, s. 3143-3150
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Journal article (peer-reviewed)abstract
- The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.
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