SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "id:"swepub:oai:lup.lub.lu.se:45f6106c-2a63-4536-9eef-56a4977ce865" "

Search: id:"swepub:oai:lup.lub.lu.se:45f6106c-2a63-4536-9eef-56a4977ce865"

  • Result 1-1 of 1
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Schrader, Silja, et al. (author)
  • Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes
  • 2021
  • In: Epigenomics. - : Future Medicine Ltd. - 1750-1911 .- 1750-192X. ; 13:12, s. 919-925
  • Journal article (peer-reviewed)abstract
    • Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Perfilyev, Alexander (1)
Ling, Charlotte (1)
Martinell, Mats, 197 ... (1)
Garcia-Calzon, Sonia (1)
Schrader, Silja (1)
University
Uppsala University (1)
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2021 (1)

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view